TMBIM1 and PROK2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMBIM1	PROK2
Description		transmembrane BAX inhibitor motif containing 1	prokineticin 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Endosome Membrane Membrane Specific Granule Membrane Extracellular Exosome	Extracellular Region
	Molecular Function	Death Receptor Binding Calcium Channel Activity Protein Binding	G Protein-coupled Receptor Binding Protein Binding
	Biological Process	Negative Regulation Of Catalytic Activity Negative Regulation Of Neuron Apoptotic Process Calcium Ion Transmembrane Transport Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Fas Signaling Pathway Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Blood Vessel Remodeling	Angiogenesis Endothelial Cell Proliferation Chemotaxis Inflammatory Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Spermatogenesis Circadian Rhythm Sensory Perception Of Pain Negative Regulation Of Apoptotic Process Positive Regulation Of Smooth Muscle Contraction Rhythmic Process
Pathways		Neutrophil degranulation	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs
Diseases			Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)
GWAS		Colorectal cancer ( 28960316) Colorectal cancer or advanced adenoma ( 30510241) Gallstone disease ( 30504769) Glycated hemoglobin levels ( 34059833) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 23128233 28067908) Red cell distribution width ( 27863252) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Serum alkaline phosphatase levels ( 33547301)	Blood protein levels ( 30072576) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494) Serum metabolite levels (CMS) ( 31636271)
Interacting Genes		13 interacting genes: B3GALNT2 BIK CD33 F2RL1 GGT6 PROK2 RCHY1 RIC3 SLC10A1 SOCS5 TMEM242 TRIM55 TRIM63	1 interacting genes: TMBIM1
Entrez ID		64114	60675
HPRD ID		17884	08446
Ensembl ID		ENSG00000135926	ENSG00000163421
Uniprot IDs		B3KSM0 B4DUD2 Q969X1	Q9HC23
PDB IDs
Enriched GO Terms of Interacting Partners?			Regulation Of Fas Signaling Pathway Positive Regulation Of Blood Vessel Remodeling Negative Regulation Of Fas Signaling Pathway Regulation Of Blood Vessel Remodeling Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Death Receptor Binding Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Tissue Remodeling Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Calcium Channel Activity Regulation Of Tissue Remodeling Specific Granule Membrane Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Protein Localization To Plasma Membrane Regulation Of Protein Localization To Cell Periphery Negative Regulation Of Catalytic Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Protein Localization To Membrane Negative Regulation Of Neuron Apoptotic Process Calcium Ion Transmembrane Transport Negative Regulation Of Protein Localization Negative Regulation Of Apoptotic Signaling Pathway Calcium Ion Transport Regulation Of Neuron Apoptotic Process
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