TMBIM1 and GGT6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMBIM1	GGT6
Description		transmembrane BAX inhibitor motif containing 1	gamma-glutamyltransferase 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Endosome Membrane Membrane Specific Granule Membrane Extracellular Exosome	Membrane Extracellular Exosome
	Molecular Function	Death Receptor Binding Calcium Channel Activity Protein Binding	Protein Binding Transferase Activity Acyltransferase Activity Hydrolase Activity Glutathione Hydrolase Activity Leukotriene C4 Gamma-glutamyl Transferase Activity
	Biological Process	Negative Regulation Of Catalytic Activity Negative Regulation Of Neuron Apoptotic Process Calcium Ion Transmembrane Transport Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Fas Signaling Pathway Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Blood Vessel Remodeling	Glutathione Metabolic Process Glutathione Biosynthetic Process Leukotriene D4 Biosynthetic Process
Pathways		Neutrophil degranulation	Glutathione synthesis and recycling Aflatoxin activation and detoxification Paracetamol ADME
Drugs
Diseases
GWAS		Colorectal cancer ( 28960316) Colorectal cancer or advanced adenoma ( 30510241) Gallstone disease ( 30504769) Glycated hemoglobin levels ( 34059833) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 23128233 28067908) Red cell distribution width ( 27863252) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Serum alkaline phosphatase levels ( 33547301)	Rheumatoid arthritis ( 28118524) Rheumatoid arthritis (rheumatoid factor and/or anti-cyclic citrullinated peptide seropositive) ( 28118524)
Interacting Genes		13 interacting genes: B3GALNT2 BIK CD33 F2RL1 GGT6 PROK2 RCHY1 RIC3 SLC10A1 SOCS5 TMEM242 TRIM55 TRIM63	10 interacting genes: ADAM33 BMP10 ENTPD3 FAIM2 FAM3C GRINA NOTCH3 SEC22A TMBIM1 TNMD
Entrez ID		64114	124975
HPRD ID		17884	08293
Ensembl ID		ENSG00000135926	ENSG00000167741
Uniprot IDs		B3KSM0 B4DUD2 Q969X1	B4DKN3 B4DPG6 J3KPJ0 Q6P531 Q6ZPD7
PDB IDs
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Calcium Channel Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Calcium Ion Transmembrane Transport Golgi Membrane Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic Signaling Pathway Calcium Ion Transport Apoptotic Signaling Pathway Negative Regulation Of Fas Signaling Pathway Apyrase Activity Regulation Of Apoptotic Signaling Pathway Endoplasmic Reticulum Cerebellar Granular Layer Development
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