TBPL2 and MAP4K4

Number of citations of the paper that reports this interaction (PMID 15234975)
22

Data Source:
BioGRID (two hybrid)

		TBPL2	MAP4K4
Gene Name		TATA box binding protein like 2	mitogen-activated protein kinase kinase kinase kinase 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Cytoplasm
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity	Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding
	Biological Process	DNA-templated Transcription, Initiation Multicellular Organismal Development Negative Regulation Of Transcription, DNA-templated	Protein Phosphorylation Signal Transduction By Phosphorylation Microvillus Assembly Intracellular Signal Transduction Regulation Of JNK Cascade Regulation Of Catalytic Activity
Pathways			Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS			Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885)
Protein-Protein Interactions		4 interactors: DNAJB4 DNAJB5 KPNA2 MAP4K4	18 interactors: BRCA1 CASP8 DOK1 GBP3 HIST2H2BE ITGB1 KIF26B KIF5A MAP3K7 NCK1 NME7 PPP1CA PPP1CC PRKCE RAP2A RASA1 SLC9A1 TBPL2
Entrez ID		387332	9448
HPRD ID		10607	05235
Ensembl ID			ENSG00000071054
Uniprot IDs		Q6SJ96	B7Z3V5 O95819
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Unfolded Protein Protein Folding Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus	Response To External Stimulus Regulation Of Cell Adhesion Multicellular Organismal Development Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Signaling Developmental Process Signaling Regulation Of Signaling Enzyme Linked Receptor Protein Signaling Pathway Cell Communication Response To Stimulus Cellular Response To Organic Substance Anatomical Structure Development Regulation Of Cellular Component Organization Negative Regulation Of Cell Death Regulation Of Apoptotic Process System Development Positive Regulation Of Cell Adhesion Regulation Of Cell Death Signal Transduction Response To Abiotic Stimulus Response To Other Organism Response To Transforming Growth Factor Beta Regulation Of Cell-substrate Adhesion Cell Projection Organization Response To Biotic Stimulus Nervous System Development Cellular Response To Mechanical Stimulus MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Anatomical Structure Morphogenesis Cell Surface Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Intracellular Signal Transduction Toll-like Receptor 4 Signaling Pathway Defense Response Response To Organic Substance Axonogenesis Regulation Of Organelle Organization Negative Regulation Of Necroptotic Process Negative Regulation Of Programmed Cell Death Axon Development Negative Regulation Of Necrotic Cell Death Response To Stress Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Necroptotic Process Movement Of Cell Or Subcellular Component
Tagcloud ?		bimodular comprises dbd gallus gametogenesis genomics gonads homo intrinsically invertebrates iups melanogaster mus musculus norvegicus rattus rubripes sapiens subphylum tafs takifugu tata tbpl1 troglodytes tropicalis ubiquitously unstructured vertebrates	abstract array cascade complicated crc downregulated downstream dual evidences explored jun kaplan luciferase mdm2 meier microarray micrornas mir mirna mirnas multistep noncancerous numerous obstacles obviously reporter serve tnm tumorigenesis
Tagcloud (Difference) ?		bimodular comprises dbd gallus gametogenesis genomics gonads homo intrinsically invertebrates iups melanogaster mus musculus norvegicus rattus rubripes sapiens subphylum tafs takifugu tata tbpl1 troglodytes tropicalis ubiquitously unstructured vertebrates	abstract array cascade complicated crc downregulated downstream dual evidences explored jun kaplan luciferase mdm2 meier microarray micrornas mir mirna mirnas multistep noncancerous numerous obstacles obviously reporter serve tnm tumorigenesis
Tagcloud (Intersection) ?