MED19 and MED17

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		MED19	MED17
Description		mediator complex subunit 19	mediator complex subunit 17
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mediator Complex Core Mediator Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Transcription Regulator Complex Membrane Mediator Complex Core Mediator Complex
	Molecular Function	Transcription Coregulator Activity Protein Binding	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Nuclear Vitamin D Receptor Binding Nuclear Thyroid Hormone Receptor Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II	Regulation Of Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Protein Ubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II Somatic Stem Cell Population Maintenance Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Neuroticism ( 29255261) Reticulocyte count ( 32888494) Schizophrenia ( 25056061 28991256 29483656)
Interacting Genes		19 interacting genes: APP DCK DHRS7B DTX2 GRB2 HLCS KANK2 MED17 MED27 MED31 MED8 MED9 MSX1 NEDD9 NFKBIA OSTF1 RADIL RIPPLY1 ZNF76	17 interacting genes: BCL6 CEBPA CTDP1 ESR1 ESR2 HEMGN HNF4A MED19 MED22 MED30 MED8 PPARGC1A SMARCA4 SREBF1 SUZ12 TP53 USP49
Entrez ID		219541	9440
HPRD ID		17477	04816
Ensembl ID		ENSG00000156603	ENSG00000042429
Uniprot IDs		A0JLT2 J3KR33	Q9NVC6
PDB IDs		7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8TQW 8TRH	7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription Initiation By RNA Polymerase II Core Mediator Complex Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Mediator Complex RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Protein-DNA Complex Assembly Positive Regulation Of Transcription By RNA Polymerase II Ubiquitin Ligase Complex Transcription Coregulator Activity Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Ubiquitin Protein Ligase Activity Positive Regulation Of RNA Metabolic Process Regulation Of Dendritic Spine Maintenance Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Post-translational Protein Modification Notch Signaling Pathway Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Ephrin Receptor Binding Protein Ubiquitination Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Macromolecule Biosynthetic Process Signal Transduction Involved In Regulation Of Gene Expression Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Biosynthetic Process Positive Regulation Of Lymphocyte Migration Nucleoplasm Guanyl-nucleotide Exchange Factor Adaptor Activity Biotin--[biotin Carboxyl-carrier Protein] Ligase Activity Negative Regulation Of Odontoblast Differentiation Acylglycerone-phosphate Reductase (NADP+) Activity Transcription Initiation At RNA Polymerase II Promoter Negative Regulation Of Protein Localization To Nucleus	Nucleoplasm Regulation Of Transcription By RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Polymerase II Preinitiation Complex Assembly Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription Initiation By RNA Polymerase II Sequence-specific DNA Binding Chromatin Binding Positive Regulation Of RNA Metabolic Process Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of Cell Growth Regulation Of Nucleobase-containing Compound Metabolic Process Core Mediator Complex Protein-DNA Complex Assembly Positive Regulation Of Nucleobase-containing Compound Metabolic Process Mediator Complex Negative Regulation Of Growth Nucleus RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Activity Nuclear Receptor Activity Regulation Of Gene Expression Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of MiRNA Transcription Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Regulation Of MiRNA Metabolic Process DNA-binding Transcription Factor Activity RNA Metabolic Process Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of RNA Metabolic Process DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Elongation
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