MED19 and RADIL

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MED19	RADIL
Gene Name		mediator complex subunit 19	Ras association and DIL domains
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mediator Complex	Microtubule
	Molecular Function	RNA Polymerase II Transcription Cofactor Activity Protein Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter	Signal Transduction Multicellular Organismal Development Substrate Adhesion-dependent Cell Spreading
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		11 interactors: APP DCK DHRS7B MED17 MED27 MED31 MED8 MED9 MSX1 NFKBIA RADIL	13 interactors: ASCC2 CEP76 FGFR3 GATA1 KRT31 LITAF MAGEA11 MED19 MRFAP1L1 RHOXF2 SFI1 USP7 YWHAB
Entrez ID		219541	55698
HPRD ID		17477	07663
Ensembl ID		ENSG00000156603	ENSG00000157927
Uniprot IDs		A0JLT2	F5H6X3 Q96JH8
PDB IDs			1UM1 3EC8
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Negative Regulation Of Cell Differentiation Intracellular Receptor Signaling Pathway Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Stem Cell Development Regulation Of Binding Negative Regulation Of DNA Binding Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Stem Cell Differentiation Cellular Nitrogen Compound Metabolic Process Regulation Of Cell Differentiation Nitrogen Compound Metabolic Process Regulation Of DNA Binding Cell Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Synaptic Growth At Neuromuscular Junction Negative Regulation Of Binding Collateral Sprouting In Absence Of Injury Positive Regulation Of Mesenchymal Cell Apoptotic Process Embryonic Nail Plate Morphogenesis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Activation Of Meiosis Biosynthetic Process Stem Cell Maintenance Collateral Sprouting BMP Signaling Pathway Involved In Heart Development Axon Midline Choice Point Recognition Positive Regulation Of Transcription, DNA-templated Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cytoplasmic Sequestering Of NF-kappaB Protein Localization To Nucleus Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process	Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Dephosphorylation Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Regulation Of Metabolic Process Basophil Differentiation Eosinophil Fate Commitment G2/M Transition Of Mitotic Cell Cycle Eosinophil Differentiation Transcriptional Activation By Promoter-enhancer Looping Regulation Of Dephosphorylation Cellular Response To Hormone Stimulus Insulin Receptor Signaling Pathway Regulation Of Definitive Erythrocyte Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Negative Regulation Of Protein Dephosphorylation Alveolar Secondary Septum Development Negative Regulation Of Protein Transport Axonogenesis Involved In Innervation Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Phosphorus Metabolic Process Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Maintenance Of DNA Methylation Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Regulation Of Peptidyl-tyrosine Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Chondrocyte Proliferation Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway MAPK Cascade Cellular Response To Thyroid Hormone Stimulus Positive Regulation Of Osteoblast Proliferation Positive Regulation Of Intracellular Signal Transduction Regulation Of Centriole Replication Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Regulation Of Cellular Process Mitotic Cell Cycle Phase Transition Positive Regulation Of Phosphorylation Cell Cycle Phase Transition
Tagcloud ?		adp b1 cyclin downregulated enneking iib iiib ki67 knockdown mediator multimodal nearly nude oncogene oncogenes os osteosarcoma parp pcna proliferating remarkably ribose saos simultaneously spreading tumour tumourigenesis u2os xenograft	adhesion adhesiveness associates concurrent dynamics effector effectors emerging focal gtpase influences inside integrin kif14 kinesin mediate microtubules migration negatively optimal pdz polarity rap rap1 reach regulates spreading tethering thereby
Tagcloud (Difference) ?		adp b1 cyclin downregulated enneking iib iiib ki67 knockdown mediator multimodal nearly nude oncogene oncogenes os osteosarcoma parp pcna proliferating remarkably ribose saos simultaneously tumour tumourigenesis u2os xenograft	adhesion adhesiveness associates concurrent dynamics effector effectors emerging focal gtpase influences inside integrin kif14 kinesin mediate microtubules migration negatively optimal pdz polarity rap rap1 reach regulates tethering thereby
Tagcloud (Intersection) ?		spreading