MED23 and PUM2

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
HPRD (two hybrid)

		MED23	PUM2
Description		mediator complex subunit 23	pumilio RNA binding family member 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Mediator Complex Core Mediator Complex	Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Membrane Neuronal Cell Body Perinuclear Region Of Cytoplasm Postsynapse Glutamatergic Synapse
	Molecular Function	Transcription Coactivator Activity Protein Binding	RNA Binding MRNA 3'-UTR Binding Protein Binding MiRNA Binding Pumilio-response Element Binding LncRNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Transcription Elongation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of T Cell Extravasation	Skeletal System Development Hair Follicle Development Regulation Of Translation Mitochondrion Organization Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Respiratory Electron Transport Chain Stress Granule Assembly MiRNA Processing Regulation Of MRNA Stability Positive Regulation Of Sprouting Of Injured Axon Chromosome Organization Regulation Of Chromosome Segregation Adipose Tissue Development Regulation Of MiRNA-mediated Gene Silencing 3'-UTR-mediated MRNA Destabilization Regulation Of Postsynapse Assembly Positive Regulation Of RIG-I Signaling Pathway Regulation Of Intracellular MRNA Localization Positive Regulation Of MiRNA-mediated Gene Silencing
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Neddylation
Drugs
Diseases
GWAS		L-arginine levels ( 25245031) Type 2 diabetes ( 30054458)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Body mass index ( 28892062) Low density lipoprotein cholesterol levels ( 32154731)
Interacting Genes		17 interacting genes: CEBPA CEBPB CTDP1 ELF3 ESR1 ESR2 ETS1 FOXJ3 MED13 MED9 NCOA6 PUM2 RELA SREBF1 VDR WDTC1 WEE2-AS1	25 interacting genes: AURKA COPS5 DAZ1 DAZ3 DAZ4 DAZL MED23 MED4 MIR128-2 MIR17 MIR199A1 MIR199A2 MIR214 MIR221 MIR7-1 MIR92A2 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G NANOS1
Entrez ID		9439	23369
HPRD ID		05436	09527
Ensembl ID		ENSG00000112282	ENSG00000055917
Uniprot IDs		Q05DL5 Q9ULK4	B7ZL34 Q8TB72
PDB IDs		6H02 7EMF 7ENA 7ENC 7ENJ 7LBM 8GXQ 8GXS 8T9D 8TQW 8TRH	3Q0Q 3Q0R 3Q0S
Enriched GO Terms of Interacting Partners?		Sequence-specific DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Metabolic Process Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Nucleobase-containing Compound Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Nuclear Receptor Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process C/EBP Complex Regulation Of MiRNA Transcription Nucleoplasm Nuclear Steroid Receptor Activity Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of Biosynthetic Process Intracellular Receptor Signaling Pathway CHOP-C/EBP Complex RNA Metabolic Process Macromolecule Biosynthetic Process Nuclear Estrogen Receptor Activity Mammary Gland Branching Involved In Pregnancy Chromatin Binding Histone Deacetylase Binding Response To Lipid Negative Regulation Of Macromolecule Metabolic Process	RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Post-transcriptional Regulation Of Gene Expression Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of MRNA Metabolic Process MRNA 3'-UTR Binding Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Translation Activator Activity Regulation Of Translation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway 3'-UTR-mediated MRNA Stabilization Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Extracellular Vesicle MiRNA-mediated Gene Silencing By MRNA Destabilization MRNA Destabilization RNA Destabilization Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Protein Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Connective Tissue Replacement Positive Regulation Of MRNA Catabolic Process Positive Regulation Of Translational Initiation Regulation Of Blood Vessel Endothelial Cell Migration MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Connective Tissue Replacement Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of MRNA Metabolic Process MRNA Stabilization Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Tissue Remodeling Negative Regulation Of MRNA Catabolic Process RNA Stabilization
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?