ECEL1 and USP19

Number of citations of the paper that reports this interaction (PubMedID 23500468)
0

Data Source:
BioGRID (two hybrid)

		ECEL1	USP19
Description		endothelin converting enzyme like 1	ubiquitin specific peptidase 19
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane
	Molecular Function	Metalloendopeptidase Activity Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Hsp90 Protein Binding
	Biological Process	Respiratory System Process Proteolysis Neuropeptide Signaling Pathway Protein Processing	Proteolysis Protein Deubiquitination Regulation Of Protein Stability Response To Endoplasmic Reticulum Stress ERAD Pathway Negative Regulation Of Skeletal Muscle Tissue Development Protein Stabilization Positive Regulation Of Cell Cycle Process Regulation Of Cellular Response To Hypoxia Regulation Of ERAD Pathway
Pathways			Ub-specific processing proteases
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Smoking cessation ( 33082346) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		1 interacting genes: USP19	14 interacting genes: BIRC3 CKAP5 ECEL1 FLNA HIF1A HNRNPAB HSP90AA1 LAMTOR4 RNF2 SIAH1 SIAH2 SNRNP200 TP53 UBC
Entrez ID		9427	10869
HPRD ID		07066	18278
Ensembl ID		ENSG00000171551	ENSG00000172046
Uniprot IDs		A0A6F7YIA8 O95672	A0A0A0MR08 A0A8I5KT08 A0A8I5KV50 A0A8I5KXK1 O94966
PDB IDs			1WH0 4X3G 6K7W 6KHV 6KQV
Enriched GO Terms of Interacting Partners?		Histone H4K5ac Reader Activity Histone H4K12ac Reader Activity Acetylation-dependent Protein Binding Histone H3K14ac Reader Activity Negative Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Cell Fate Commitment T-helper 17 Cell Lineage Commitment Positive Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of T-helper 17 Cell Lineage Commitment Negative Regulation Of Muscle Organ Development Negative Regulation Of Muscle Tissue Development Negative Regulation Of Striated Muscle Tissue Development T-helper Cell Lineage Commitment CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Alpha-beta T Cell Lineage Commitment Positive Regulation Of T-helper 17 Type Immune Response CD4-positive, Alpha-beta T Cell Lineage Commitment Chromatin Looping Regulation Of Cellular Response To Hypoxia Regulation Of ERAD Pathway Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of T-helper Cell Differentiation Regulation Of T-helper 17 Cell Differentiation T Cell Lineage Commitment Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of T-helper 17 Type Immune Response Regulation Of Striated Muscle Tissue Development Hsp90 Protein Binding Regulation Of Cell Fate Commitment Regulation Of Muscle Organ Development Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of T-helper Cell Differentiation Protein Localization To Chromatin Positive Regulation Of Alpha-beta T Cell Differentiation Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Alpha-beta T Cell Activation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of CD4-positive, Alpha-beta T Cell Activation Neural Tube Closure Tube Closure Regulation Of Response To Endoplasmic Reticulum Stress Cysteine-type Deubiquitinase Activity ERAD Pathway Protein Deubiquitination	Cell Death Regulation Of Apoptotic Process Apoptotic Process Protein-containing Complex Regulation Of Post-translational Protein Modification Programmed Cell Death Ubiquitin-protein Transferase Activity Regulation Of Neural Precursor Cell Proliferation Regulation Of Thymocyte Apoptotic Process Cardiac Muscle Cell Apoptotic Process Striated Muscle Cell Apoptotic Process Regulation Of Programmed Cell Death Ubiquitin Protein Ligase Binding Lactate Metabolic Process Neuron Apoptotic Process Response To Salt Stress Muscle Cell Apoptotic Process Macromolecule Metabolic Process Ubiquitin Protein Ligase Activity Histone Deacetylase Binding Regulation Of Protein Stability Disordered Domain Specific Binding Regulation Of Apoptotic Signaling Pathway Amyloid Fibril Formation Ubiquitin Conjugating Enzyme Binding Regulation Of Protein Ubiquitination Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Programmed Necrotic Cell Death Negative Regulation Of RNA Metabolic Process Positive Regulation Of Protein Import Into Nucleus GTPase Binding Supramolecular Fiber Organization Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of T Cell Apoptotic Process Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Protein-containing Complex Assembly Response To Antibiotic Regulation Of Neuroblast Proliferation Regulation Of Telomere Maintenance Via Telomerase Regulation Of Protein Metabolic Process Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Localization Positive Regulation Of Organelle Organization Protein Metabolic Process Neuroblast Proliferation Transcription Coactivator Binding CTP Binding
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