TCF3 and ID1

Number of citations of the paper that reports this interaction (PubMedID 35440621)
87

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (in vivo)

		TCF3	ID1
Description		transcription factor 3	inhibitor of DNA binding 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Protein-containing Complex RNA Polymerase II Transcription Regulator Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Vitamin D Response Element Binding E-box Binding DNA-binding Transcription Factor Binding	Transcription Corepressor Activity Protein Binding Protein Dimerization Activity Transcription Regulator Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II B Cell Lineage Commitment Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Cell Differentiation B Cell Differentiation Positive Regulation Of B Cell Proliferation Immunoglobulin V(D)J Recombination Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Endothelial Cell Morphogenesis Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway Heart Development Circadian Rhythm Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Neuron Differentiation BMP Signaling Pathway Protein Destabilization Collagen Metabolic Process Regulation Of MAPK Cascade Negative Regulation Of DNA-binding Transcription Factor Activity Blood Vessel Endothelial Cell Migration Negative Regulation Of Osteoblast Differentiation Regulation Of Angiogenesis Negative Regulation Of DNA-templated Transcription Response To Antibiotic Rhythmic Process Blood Vessel Morphogenesis Lung Morphogenesis Lung Vasculature Development Endothelial Cell Apoptotic Process Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Myogenesis Myogenesis RUNX1 regulates transcription of genes involved in differentiation of HSCs Negative Regulation of CDH1 Gene Transcription TGFBR3 expression	Oncogene Induced Senescence NGF-stimulated transcription Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Hodgkin's lymphoma ( 24920014 29196614) Monocyte count ( 32888494) Objective response to lithium treatment ( 26503763) Triglyceride levels ( 34074324)	Diastolic blood pressure ( 27841878) Systolic blood pressure ( 27841878)
Interacting Genes		66 interacting genes: AEBP1 ASCL3 AURKA BHLHA15 BHLHE40 CALM1 CALM3 CBFA2T3 CREBBP CTNNB1 DACH1 DAXX ELK3 EP300 FERD3L GLIS1 HAND1 HAND2 HOXA1 ID1 ID2 ID3 KAT2A KAT2B LMX1A LMX1B LYL1 MAPK1 MAPK3 MAPKAPK2 MAPKAPK3 MDFI MEN1 MSC MYF5 MYF6 MYOD1 MYOG NEDD9 NEUROD1 NHLH1 NSD3 PARP1 PDX1 PSMD4 PSMD9 RALGAPA1 RPL37 RUNX1T1 SCX SKP2 SRF SUPT3H TADA2A TAL1 TAL2 TCAF1 TCF12 TCF21 TCF4 TFPT TLE1 TRRAP TWIST1 UBE2I USF1	26 interacting genes: APPL1 ASCL3 CASK COPB1 DNMT3L ELK1 ELK4 GATA4 HES1 IFI16 IKBKG MSGN1 MYF5 MYF6 MYOD1 MYOG PSMD4 RNF4 RUNX1T1 SUV39H1 TCF12 TCF3 TCF4 TRIM55 TRIM63 UBC
Entrez ID		6929	3397
HPRD ID		00918	08980
Ensembl ID		ENSG00000071564	ENSG00000125968
Uniprot IDs		P15923	P41134
PDB IDs		2MH0 2YPA 2YPB 3U5V 6MGN
Enriched GO Terms of Interacting Partners?		Protein Dimerization Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Nucleus Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process E-box Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process DNA Binding BHLH Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Nucleoplasm Sequence-specific Double-stranded DNA Binding Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Cell Differentiation Negative Regulation Of Metabolic Process Cell Differentiation Animal Organ Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Developmental Process Animal Organ Morphogenesis Regulation Of Developmental Process Embryonic Morphogenesis	Positive Regulation Of Transcription By RNA Polymerase II E-box Binding Protein Dimerization Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Skeletal Muscle Fiber Development Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Macromolecule Metabolic Process DNA Binding Chromatin Nucleus DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Muscle Cell Fate Commitment Positive Regulation Of Metabolic Process Cell Fate Commitment Sequence-specific Double-stranded DNA Binding Positive Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Striated Muscle Tissue Development Regulation Of Gene Expression DNA-binding Transcription Factor Activity RNA Polymerase II Transcription Regulator Complex Regulation Of Skeletal Muscle Tissue Development Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Anterior/posterior Pattern Specification Regulation Of Striated Muscle Tissue Development Positive Regulation Of Striated Muscle Cell Differentiation Regulation Of Muscle Organ Development Regulation Of Myotube Differentiation Positive Regulation Of Myoblast Differentiation Regulation Of Metabolic Process Somitogenesis Animal Organ Development Cell Differentiation Regulation Of Macromolecule Metabolic Process Tissue Regeneration Segmentation Muscle Organ Development
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