ARHGAP29 and RAP2A

Number of citations of the paper that reports this interaction (PubMedID 15752761)
0

Data Source:
HPRD (two hybrid, in vitro)

		ARHGAP29	RAP2A
Description		Rho GTPase activating protein 29	RAP2A, member of RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Protein-containing Complex	Lysosome Endosome Golgi Apparatus Cytosol Plasma Membrane Endomembrane System Membrane Midbody Cytoplasmic Vesicle Membrane Lamellipodium Membrane Endolysosome Cell Projection Synapse Recycling Endosome Recycling Endosome Membrane Synaptic Membrane Bounding Membrane Of Organelle Schaffer Collateral - CA1 Synapse
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding PDZ Domain Binding Metal Ion Binding	Nucleotide Binding Magnesium Ion Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding
	Biological Process	Signal Transduction Rho Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction	Signal Transduction Intracellular Protein Localization Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Rap Protein Signal Transduction Establishment Of Protein Localization Regulation Of JNK Cascade Regulation Of Dendrite Morphogenesis Regulation Of Synapse Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Microvillus Assembly
Pathways		RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs			Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) D-dimer levels ( 21502573) Plateletcrit ( 32888494) Systolic blood pressure ( 30224653)	Gut microbiota (bacterial taxa) ( 27723756) Peripheral artery disease ( 26488411)
Interacting Genes		7 interacting genes: HRAS KDM1A MAGEA11 PTPN13 RAP2A RHOA TRIM54	32 interacting genes: ACVR1 AFDN ARHGAP29 BMPR1B EEF1A1 ENSA FKBP2 FNTB FTL GABARAPL2 GRIN1 GRIN2D MAP4K4 NEDD4 PLG RAB40B RAF1 RALGDS RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASIP1 RASSF5 RGS14 RRP9 RUNDC3A SERPINA1 SMAD1 TGFBR1 TM7SF2 TNIK
Entrez ID		9411	5911
HPRD ID		06674	01547
Ensembl ID		ENSG00000137962	ENSG00000125249
Uniprot IDs		A0A2X0U4J5 Q52LW3	P10114
PDB IDs			1KAO 2RAP 3RAP
Enriched GO Terms of Interacting Partners?		G Protein Activity Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Cellular Response To Gamma Radiation Regulation Of Cell Junction Assembly Small GTPase-mediated Signal Transduction Regulation Of Synapse Organization GTPase Activity Response To Gamma Radiation Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation GTP Binding Regulation Of Intracellular Signal Transduction GDP Binding Cellular Response To Ionizing Radiation Positive Regulation Of Cell Projection Organization Regulation Of Cell Size Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Neuron Projection Development Positive Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Biogenesis Neuron Apoptotic Process Aortic Valve Formation Positive Regulation Of Vascular Associated Smooth Muscle Contraction Endothelial Tube Lumen Extension Regulation Of Neural Precursor Cell Proliferation Skeletal Muscle Satellite Cell Migration GTPase Complex Negative Regulation Of Excitatory Synapse Assembly Response To Toxic Substance Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Regulation Of Cytoskeleton Organization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cell Migration Beta Selection Positive Regulation Of Cell Motility Phospholipase C Activator Activity Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Locomotion Response To Ionizing Radiation Regulation Of JNK Cascade Regulation Of Protein Modification Process Bone Trabecula Morphogenesis Protein Demethylase Activity Negative Regulation Of Metabolic Process Apolipoprotein A-I-mediated Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Regulation Of Microtubule Cytoskeleton Organization	Intracellular Signaling Cassette Signal Transduction Transforming Growth Factor Beta Receptor Activity, Type I Intracellular Signal Transduction Ras Protein Signal Transduction Small GTPase-mediated Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling GTPase Regulator Activity Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Microvillus Assembly Protein Kinase Activity Establishment Of Endothelial Barrier Activin Receptor Complex Activin Receptor Activity, Type I NMDA Glutamate Receptor Activity Glutamate Binding Endothelial Cell Development Guanyl-nucleotide Exchange Factor Activity BMP Receptor Activity Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition SMAD Binding NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Positive Regulation Of Signal Transduction Kinase Activity Potassium Channel Inhibitor Activity Excitatory Chemical Synaptic Transmission Regulation Of Microvillus Assembly Activin Binding Cellular Response To Growth Factor Stimulus Enzyme-linked Receptor Protein Signaling Pathway Plasma Membrane Regulation Of Type B Pancreatic Cell Proliferation Regulation Of Intracellular Signal Transduction Protein Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction Nucleotide Binding Regulation Of Insulin Secretion Response To Growth Factor Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Osteoblast Differentiation Regulation Of Cartilage Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway I-SMAD Binding Positive Regulation Of Cellular Component Biogenesis
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