ARHGAP18 and MPHOSPH6

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
HPRD (two hybrid)

		ARHGAP18	MPHOSPH6
Gene Name		Rho GTPase activating protein 18	M-phase phosphoprotein 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleolus Cytoplasm
	Molecular Function	GTPase Activator Activity	RNA Binding Protein Binding
	Biological Process	Small GTPase Mediated Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Maturation Of 5.8S RRNA
Pathways		Rho GTPase cycle Signaling by Rho GTPases
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) ( 23648065) Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		2 interactors: MPHOSPH6 MPP6	24 interactors: AATF APLP1 ARHGAP18 C14orf1 DNM2 DYNLRB1 EIF3G EXOSC10 FTL GDF9 KNSTRN LRIF1 NUPR1 PARN RBM48 RPS20 SKIV2L2 SMARCA4 SNX9 THOP1 TLE1 TP53 UNC119 ZHX1
Entrez ID		93663	10200
HPRD ID		12474	16111
Ensembl ID		ENSG00000146376	ENSG00000135698
Uniprot IDs		Q8N392	Q99547
PDB IDs
Enriched GO Terms of Interacting Partners?		Maturation Of 5.8S RRNA RRNA Processing RRNA Metabolic Process Ribosome Biogenesis Ribonucleoprotein Complex Biogenesis NcRNA Metabolic Process	Gene Expression RNA Metabolic Process Regulation Of Female Gonad Development Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Metabolic Process Maturation Of 5.8S RRNA Positive Regulation Of Protein Oligomerization Ribonucleoprotein Complex Biogenesis Regulation Of Cell Growth Endocytosis Regulation Of Protein Oligomerization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Mitotic Cell Cycle Process Nuclear-transcribed MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Negative Regulation Of Cell Growth MRNA Catabolic Process Negative Regulation Of Fibroblast Proliferation Nitrogen Compound Metabolic Process Mitotic Cell Cycle Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Cell Division Regulation Of Gene Expression RNA Catabolic Process Ribosome Biogenesis Regulation Of Metabolic Process Mitotic Cytokinesis Negative Regulation Of Reactive Oxygen Species Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Clathrin-mediated Endocytosis Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Membrane Organization Growth Negative Regulation Of Biosynthetic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Growth Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process RNA Processing Regulation Of Apoptotic Process Negative Regulation Of Macromitophagy Negative Regulation Of Membrane Tubulation Lipid Tube Assembly Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Negative Regulation Of Caveolin-mediated Endocytosis Oocyte Growth
Tagcloud ?		circuitry connectivity ctxn3 deeper dlpfc epistatic fgf17 forebrain glypican gpc1 gsea gwas leverages networks neuroimaging perturbed postmortem qt quantifying reorganization robo1 robo2 rsrc1 slc12a2 strengths tnik trait unanticipated visualizing
Tagcloud (Difference) ?		circuitry connectivity ctxn3 deeper dlpfc epistatic fgf17 forebrain glypican gpc1 gsea gwas leverages networks neuroimaging perturbed postmortem qt quantifying reorganization robo1 robo2 rsrc1 slc12a2 strengths tnik trait unanticipated visualizing
Tagcloud (Intersection) ?