ARHGAP18

Description		Rho GTPase activating protein 18
Image		No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Cytoplasmic Microtubule Plasma Membrane Nuclear Speck
	Molecular Function	GTPase Activator Activity Cadherin Binding
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Cell Shape Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Motility
Pathways		RHOA GTPase cycle RHOC GTPase cycle
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) ( 23648065) Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Axial length ( 24144296) Cognitive function ( 24684796) Heel bone mineral density ( 30598549) Heel bone mineral density x serum urate levels interaction ( 34046847) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Periodontal disease-related phenotype (Socransky) ( 24347629)
Novel Interacting Genes		1 novel interacting genes: BCS1L
Interacting Genes		2 interacting genes: MPHOSPH6 PALS2
Entrez ID		93663
HPRD ID		12474
Ensembl ID		ENSG00000146376
Uniprot IDs		Q8N392
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Insertion Into Mitochondrial Inner Membrane Mitochondrial Cytochrome C Oxidase Assembly NADH Dehydrogenase Complex Assembly Respiratory Chain Complex IV Assembly Respiratory Chain Complex III Mitochondrial Respiratory Chain Complex III Assembly Inner Mitochondrial Membrane Organization Establishment Of Protein Localization To Mitochondrial Membrane Mitochondrial Respiratory Chain Complex I Assembly Cytochrome Complex Assembly Protein Insertion Into Mitochondrial Membrane Protein Insertion Into Mitochondrial Inner Membrane From Matrix Maturation Of 5.8S RRNA Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Organelle Protein Insertion Into Membrane Establishment Of Protein Localization To Mitochondrion Protein-containing Complex Assembly Mitochondrial Respiratory Chain Complex Assembly
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