LHX2 and KHK

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LHX2	KHK
Description		LIM homeobox 2	ketohexokinase
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Sequence-specific DNA Binding Metal Ion Binding	Nucleotide Binding Ketohexokinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Homodimerization Activity Fructose Binding
	Biological Process	Neural Tube Closure Hair Follicle Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Axon Guidance Brain Development Mesoderm Development Dorsal/ventral Pattern Formation Telencephalon Development Olfactory Bulb Development Telencephalon Regionalization Cerebral Cortex Development Neurogenesis Neuron Differentiation Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Formation Involved In Morphogenesis Axon Extension Negative Regulation Of Neurogenesis Retina Development In Camera-type Eye Positive Regulation Of Neural Precursor Cell Proliferation	Fructose Metabolic Process Response To Sucrose Response To Glucose Response To Fructose Response To Zinc Ion Response To Insulin Carbohydrate Phosphorylation Regulation Of Glycogen Metabolic Process
Pathways		Regulation of expression of SLITs and ROBOs Expression and translocation of olfactory receptors	Essential fructosuria Fructose catabolism
Drugs
Diseases
GWAS		Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Blond vs. brown/black hair color ( 30531825) Depression ( 29700475) Hair color ( 29662168) Mercury levels ( 26025379) Post-traumatic stress disorder ( 25456346) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Waist circumference ( 23966867)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Self-reported risk-taking behaviour ( 30181555) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		30 interacting genes: ANKS1A ARHGAP32 BEND2 CITED2 DNMT3L FLYWCH1 HOMER3 HOXC8 KHK LGALSL LNX1 LONRF1 MORF4L1 MORN3 MSX1 NFIA NFIB NFIC OSMR PAX6 POU4F2 PPIL1 RLIM TCEANC TCP11L1 TLK1 TRAPPC2L UBTFL1 ZFP42 ZNF511	4 interacting genes: APPBP2 GLP1R LHX2 LHX9
Entrez ID		9355	3795
HPRD ID		04786	11774
Ensembl ID		ENSG00000106689	ENSG00000138030
Uniprot IDs		B3KNJ5 P50458	A0A140VJM6 C9JDL1 P50053
PDB IDs			2HLZ 2HQQ 2HW1 3B3L 3NBV 3NBW 3NC2 3NC9 3NCA 3Q92 3QA2 3QAI 3RO4 5WBM 5WBO 5WBP 5WBQ 5WBR 5WBZ 6UL7 6W0N 6W0W 6W0X 6W0Y 6W0Z 8OME 8OMF 8OMJ 8OMK 8UG1 8UG3 9FHD 9FHE
Enriched GO Terms of Interacting Partners?		Glial Cell Fate Specification Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Retina Development In Camera-type Eye Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Animal Organ Development Regulation Of Transcription By RNA Polymerase II DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Gene Expression Forebrain Development Regulation Of Timing Of Cell Differentiation Regulation Of Development, Heterochronic Exit From Mitosis Embryonic Camera-type Eye Morphogenesis Negative Regulation Of Biosynthetic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Synapse Maturation Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription BMP Signaling Pathway Response To Wounding Sequence-specific Double-stranded DNA Binding Nucleus DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cell Fate Specification Regulation Of Primary Metabolic Process Generation Of Neurons Regulation Of Macromolecule Metabolic Process Neural Precursor Cell Proliferation Anatomical Structure Morphogenesis Regulation Of Chromatin Organization Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of RNA Metabolic Process Transcription Regulator Complex DNA-templated Transcription Histone Acetyltransferase Binding Embryonic Eye Morphogenesis	Glucagon-like Peptide 1 Receptor Activity Gonad Morphogenesis Dorsal Spinal Cord Interneuron Anterior Axon Guidance Spinal Cord Interneuron Axon Guidance Glucagon Receptor Activity Interneuron Axon Guidance Neuron Projection Guidance Axon Guidance Response To Psychosocial Stress Maintenance Of Epithelial Cell Apical/basal Polarity Telencephalon Regionalization Anterior/posterior Axon Guidance Post-translational Protein Targeting To Membrane, Translocation Cellular Response To Glucagon Stimulus Neuron Differentiation RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Activation Of Adenylate Cyclase Activity Maintenance Of Cell Polarity Positive Regulation Of Lyase Activity Positive Regulation Of Adenylate Cyclase Activity Response To Glucagon Sequence-specific DNA Binding Neuron Projection Development Cul2-RING Ubiquitin Ligase Complex Positive Regulation Of Cyclase Activity Intracellular Protein Transport Olfactory Bulb Development Female Gonad Development
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