LHX2 and OSMR

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LHX2	OSMR
Description		LIM homeobox 2	oncostatin M receptor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Plasma Membrane Oncostatin-M Receptor Complex External Side Of Plasma Membrane Membrane Apical Plasma Membrane Receptor Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Sequence-specific DNA Binding Metal Ion Binding	Cytokine Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Growth Factor Binding Cytokine Binding
	Biological Process	Neural Tube Closure Hair Follicle Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Axon Guidance Brain Development Mesoderm Development Dorsal/ventral Pattern Formation Telencephalon Development Olfactory Bulb Development Telencephalon Regionalization Cerebral Cortex Development Neurogenesis Neuron Differentiation Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Formation Involved In Morphogenesis Axon Extension Negative Regulation Of Neurogenesis Retina Development In Camera-type Eye Positive Regulation Of Neural Precursor Cell Proliferation	Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Response To Cytokine Oncostatin-M-mediated Signaling Pathway
Pathways		Regulation of expression of SLITs and ROBOs Expression and translocation of olfactory receptors	IL-6-type cytokine receptor ligand interactions
Drugs
Diseases
GWAS		Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Blond vs. brown/black hair color ( 30531825) Depression ( 29700475) Hair color ( 29662168) Mercury levels ( 26025379) Post-traumatic stress disorder ( 25456346) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Waist circumference ( 23966867)	Central retinal vein equivalent ( 31597446) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 26192919 28067908) Daytime sleep phenotypes ( 27126917) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 28067908 26192919) Microalbuminuria ( 26631737) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Postoperative survival time in hepatocellular carcinoma ( 30945673 30945699) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834) Reticulocyte fraction of red cells ( 32888494) Ulcerative colitis ( 28067908 26192919)
Interacting Genes		30 interacting genes: ANKS1A ARHGAP32 BEND2 CITED2 DNMT3L FLYWCH1 HOMER3 HOXC8 KHK LGALSL LNX1 LONRF1 MORF4L1 MORN3 MSX1 NFIA NFIB NFIC OSMR PAX6 POU4F2 PPIL1 RLIM TCEANC TCP11L1 TLK1 TRAPPC2L UBTFL1 ZFP42 ZNF511	11 interacting genes: GAPDH GPRC5D IL6ST JAK1 JAK2 LHX2 MTDH OSM SGTB SLC10A6 UBQLN2
Entrez ID		9355	9180
HPRD ID		04786	03446
Ensembl ID		ENSG00000106689	ENSG00000145623
Uniprot IDs		B3KNJ5 P50458	Q99650
PDB IDs
Enriched GO Terms of Interacting Partners?		Glial Cell Fate Specification Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Retina Development In Camera-type Eye Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Animal Organ Development Regulation Of Transcription By RNA Polymerase II DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Gene Expression Forebrain Development Regulation Of Timing Of Cell Differentiation Regulation Of Development, Heterochronic Exit From Mitosis Embryonic Camera-type Eye Morphogenesis Negative Regulation Of Biosynthetic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Synapse Maturation Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription BMP Signaling Pathway Response To Wounding Sequence-specific Double-stranded DNA Binding Nucleus DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cell Fate Specification Regulation Of Primary Metabolic Process Generation Of Neurons Regulation Of Macromolecule Metabolic Process Neural Precursor Cell Proliferation Anatomical Structure Morphogenesis Regulation Of Chromatin Organization Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of RNA Metabolic Process Transcription Regulator Complex DNA-templated Transcription Histone Acetyltransferase Binding Embryonic Eye Morphogenesis	Positive Regulation Of Homotypic Cell-cell Adhesion Interleukin-6-mediated Signaling Pathway Oncostatin-M-mediated Signaling Pathway Interleukin-11-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Growth Hormone Receptor Binding Positive Regulation Of Platelet Aggregation T-helper 17 Cell Lineage Commitment Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Multicellular Organismal Process Type II Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT T-helper Cell Lineage Commitment CD4-positive, Alpha-beta T Cell Lineage Commitment CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Alpha-beta T Cell Lineage Commitment Positive Regulation Of Acute Inflammatory Response Growth Hormone Receptor Signaling Pathway Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-17 Production Regulation Of Multicellular Organismal Process Regulation Of Platelet Aggregation T Cell Lineage Commitment Positive Regulation Of Cytokine Production Receptor Complex Response To Antibiotic Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Non-membrane Spanning Protein Tyrosine Kinase Activity Response To Cytokine Response To Peptide Regulation Of Acute Inflammatory Response Regulation Of Developmental Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Platelet Activation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Histone H3Y41 Kinase Activity Nuclear Receptor-mediated Mineralocorticoid Signaling Pathway Symbiont-induced Defense-related Programmed Cell Death Mesoderm Development Interleukin-35-mediated Signaling Pathway Oncostatin-M Receptor Binding Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport Peptidyl-cysteine S-trans-nitrosylation
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