RPL23 and BCCIP

Number of citations of the paper that reports this interaction (PubMedID 36652389)
40

Data Source:
BioGRID (cross-linking study)
HPRD (two hybrid)

		RPL23	BCCIP
Description		ribosomal protein L23	BRCA2 and CDKN1A interacting protein
Image
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Cytosol Ribosome Focal Adhesion Large Ribosomal Subunit Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Protein-containing Complex Synapse Extracellular Exosome Ribonucleoprotein Complex	Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Nuclear Cyclin-dependent Protein Kinase Holoenzyme Complex Mitotic Spindle Pole
	Molecular Function	Transcription Coactivator Binding RNA Binding Structural Constituent Of Ribosome Protein Binding Ubiquitin Protein Ligase Binding Large Ribosomal Subunit RRNA Binding Ubiquitin Ligase Inhibitor Activity	RNA Binding Protein Binding Tubulin Binding Kinase Regulator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cytoplasmic Translation Translation Ribosomal Protein Import Into Nucleus Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Protein-DNA Complex Disassembly Protein Stabilization G1 To G0 Transition Cellular Response To Actinomycin D Positive Regulation Of Signal Transduction By P53 Class Mediator Regulation Of G1 To G0 Transition Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization DNA Repair DNA Damage Response Mitotic Spindle Organization Microtubule Anchoring Neuroendocrine Cell Differentiation Mitotic Spindle Assembly
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs		(S)-3-phenyllactic acid Anisomycin Puromycin
Diseases
GWAS		Chronic obstructive pulmonary disease ( 30804561)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		17 interacting genes: APP BCCIP CDC42 CLU DAPP1 DUX4 EPS8L2 FNDC3B GRWD1 IPO5 ISG15 MEOX2 NAP1L1 PTEN RELA SNRPA UBC	28 interacting genes: ABCB1 BARD1 BRCA2 CAPZB CCDC33 CDC42 CDKN1A CPAP CSNK2B FCF1 GSK3A GSK3B H2BC15 HMGB2 ITSN2 MRPS9 OGT PDGFB PTN PTPRM RAD51 RALY RPL23 RPL38 SRC TENT5A ZNF138 ZNF19
Entrez ID		9349	56647
HPRD ID		04716	16542
Ensembl ID		ENSG00000125691	ENSG00000107949
Uniprot IDs		P62829	Q9P287
PDB IDs		4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7F5S 7OW7 7XNX 7XNY 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO	7KYQ 7KYS 8EQB 8EXE 8EXF
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Amyloid Precursor Protein Catabolic Process Central Nervous System Myelin Maintenance Neuron Projection Organization Positive Regulation Of Amyloid Fibril Formation Regulation Of Amyloid Precursor Protein Catabolic Process Protein-containing Complex Cytoplasm Myelin Maintenance Protein Tag Activity Regulation Of Amyloid Fibril Formation Regulation Of Amyloid-beta Clearance Cytosol Dendritic Spine Morphogenesis Positive Regulation Of Amyloid-beta Formation Ubiquitin Protein Ligase Binding Negative Regulation Of MiRNA Transcription Low-density Lipoprotein Particle Receptor Binding Microglial Cell Activation Positive Regulation Of Amide Metabolic Process RNA Binding Positive Regulation Of Excitatory Postsynaptic Potential Reproductive Behavior Leukocyte Activation Involved In Inflammatory Response Dendritic Spine Organization Positive Regulation Of Endocytosis Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Cell Population Proliferation Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Proteolysis Amyloid-beta Complex Growth Cone Lamellipodium Intracellular Signal Transduction Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Innate Immune Response Chromatin Binding Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Nitric Oxide Metabolic Process Postsynapse Organization Perinuclear Endoplasmic Reticulum Lumen Regulation Of Amyloid-beta Formation Regulation Of Neuronal Signal Transduction Negative Regulation Of Synaptic Vesicle Clustering Nucleus Intracellular Signaling Cassette Positive Regulation Of Receptor-mediated Endocytosis Acetylcholine Receptor Activator Activity Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cytokine Production	Nuclear Ubiquitin Ligase Complex Mitotic Recombination-dependent Replication Fork Processing Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA Damage Checkpoint Cellular Response To Ionizing Radiation Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Cellular Response To Oxygen-containing Compound Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Glycogen (starch) Synthase Activity Protein-containing Complex Regulation Of Epithelial Cell Proliferation Regulation Of Cell-substrate Adhesion Negative Regulation Of Catabolic Process Regulation Of Proteolysis Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of Cell Cycle Regulation Of Developmental Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell-substrate Adhesion Cellular Response To Interleukin-3 Response To Glycoside Regulation Of Protein Modification Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Response To Ionizing Radiation Regulation Of Protein Metabolic Process Response To Gamma Radiation Negative Regulation Of Proteolysis Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of TOR Signaling Cellular Response To Antibiotic Regulation Of Cell Migration Negative Regulation Of Catalytic Activity Negative Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Organelle Organization Regulation Of Intracellular Signal Transduction Cellular Response To Radiation Apoptotic Signaling Pathway Regulation Of Cell Motility
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