RPL23 and ISG15

Number of citations of the paper that reports this interaction (PubMedID 34599178)
110

Data Source:
BioGRID (pull down)

		RPL23	ISG15
Description		ribosomal protein L23	ISG15 ubiquitin like modifier
Image
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Cytosol Ribosome Focal Adhesion Large Ribosomal Subunit Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Protein-containing Complex Synapse Extracellular Exosome Ribonucleoprotein Complex	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Transcription Coactivator Binding RNA Binding Structural Constituent Of Ribosome Protein Binding Ubiquitin Protein Ligase Binding Large Ribosomal Subunit RRNA Binding Ubiquitin Ligase Inhibitor Activity	Integrin Binding Protein Binding Protein Tag Activity Ubiquitin Protein Ligase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cytoplasmic Translation Translation Ribosomal Protein Import Into Nucleus Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Protein-DNA Complex Disassembly Protein Stabilization G1 To G0 Transition Cellular Response To Actinomycin D Positive Regulation Of Signal Transduction By P53 Class Mediator Regulation Of G1 To G0 Transition Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Immune System Process Regulation Of Immune System Process Integrin-mediated Signaling Pathway Response To Virus Response To Bacterium Protein Ubiquitination Modification-dependent Protein Catabolic Process Positive Regulation Of Bone Mineralization Negative Regulation Of Protein Ubiquitination ISG15-protein Conjugation Positive Regulation Of Protein Oligomerization Regulation Of Type II Interferon Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production Response To Type I Interferon Defense Response To Bacterium Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Multicellular Organismal Process Defense Response To Virus Negative Regulation Of Type I Interferon-mediated Signaling Pathway Protein Localization To Mitochondrion
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Interferon alpha/beta signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses RSV-host interactions PKR-mediated signaling Modulation of host responses by IFN-stimulated genes
Drugs		(S)-3-phenyllactic acid Anisomycin Puromycin
Diseases
GWAS		Chronic obstructive pulmonary disease ( 30804561)	Blood protein levels ( 30072576)
Interacting Genes		17 interacting genes: APP BCCIP CDC42 CLU DAPP1 DUX4 EPS8L2 FNDC3B GRWD1 IPO5 ISG15 MEOX2 NAP1L1 PTEN RELA SNRPA UBC	25 interacting genes: BRAP CBX5 DDOST FUS GRPEL1 HDAC6 HIF1A KLHL26 MRTO4 NAP1L1 NCL PFN1 RPL23 RPL3 RPN2 SUMO1 TPM3 TPM4 TUBA1B UBA7 USP14 USP16 USP18 USP21 USP5
Entrez ID		9349	9636
HPRD ID		04716	00958
Ensembl ID		ENSG00000125691	ENSG00000187608
Uniprot IDs		P62829	P05161
PDB IDs		4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7F5S 7OW7 7XNX 7XNY 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO	1Z2M 2HJ8 3PHX 3PSE 3R66 3RT3 3SDL 5TL6 5W8T 5W8U 6BI8 6FFA 6XA9 7RBS 7S6P 8OIF 8SE9 8SEA 8SEB 8SV8
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Amyloid Precursor Protein Catabolic Process Central Nervous System Myelin Maintenance Neuron Projection Organization Positive Regulation Of Amyloid Fibril Formation Regulation Of Amyloid Precursor Protein Catabolic Process Protein-containing Complex Cytoplasm Myelin Maintenance Protein Tag Activity Regulation Of Amyloid Fibril Formation Regulation Of Amyloid-beta Clearance Cytosol Dendritic Spine Morphogenesis Positive Regulation Of Amyloid-beta Formation Ubiquitin Protein Ligase Binding Negative Regulation Of MiRNA Transcription Low-density Lipoprotein Particle Receptor Binding Microglial Cell Activation Positive Regulation Of Amide Metabolic Process RNA Binding Positive Regulation Of Excitatory Postsynaptic Potential Reproductive Behavior Leukocyte Activation Involved In Inflammatory Response Dendritic Spine Organization Positive Regulation Of Endocytosis Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Cell Population Proliferation Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Proteolysis Amyloid-beta Complex Growth Cone Lamellipodium Intracellular Signal Transduction Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Innate Immune Response Chromatin Binding Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Nitric Oxide Metabolic Process Postsynapse Organization Perinuclear Endoplasmic Reticulum Lumen Regulation Of Amyloid-beta Formation Regulation Of Neuronal Signal Transduction Negative Regulation Of Synaptic Vesicle Clustering Nucleus Intracellular Signaling Cassette Positive Regulation Of Receptor-mediated Endocytosis Acetylcholine Receptor Activator Activity Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cytokine Production	Cysteine-type Deubiquitinase Activity Protein Deubiquitination Regulation Of Protein Stability Protein Modification By Small Protein Removal Cysteine-type Peptidase Activity Protein Metabolic Process Post-translational Protein Modification Protein Modification Process Presynaptic Cytosol Muscle Thin Filament Tropomyosin Oligosaccharyltransferase Complex B Macromolecule Metabolic Process Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Proteolysis Ubiquitin Protein Ligase Binding Oligosaccharyltransferase Complex A Cytoplasm Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Cysteine-type Endopeptidase Activity Regulation Of Epithelial Cell Migration Oligosaccharyltransferase Complex Negative Regulation Of Catabolic Process Axonal Transport Of Mitochondrion Adenyl-nucleotide Exchange Factor Activity Regulation Of Proteolysis Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Nucleolus Peptidase Activity Ubiquitin Binding Cellular Response To Interleukin-4 Deubiquitinase Activity Protein K48-linked Deubiquitination Mitochondrion Transport Along Microtubule Response To Interleukin-4 Postsynaptic Cytosol Histone Deacetylase Binding Response To Cytokine RNA Binding Regulation Of Protein Metabolic Process Establishment Of Mitochondrion Localization Response To Peptide Proteolysis Positive Regulation Of Gene Expression Negative Regulation Of Protein Metabolic Process ISG15 Activating Enzyme Activity Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Positive Regulation Of Ribosome Biogenesis Hsp90 Protein Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?