RPL23 and EPS8L2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RPL23	EPS8L2
Description		ribosomal protein L23	EPS8 signaling adaptor L2
Image
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Cytosol Ribosome Focal Adhesion Large Ribosomal Subunit Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Protein-containing Complex Synapse Extracellular Exosome Ribonucleoprotein Complex	Cytoplasm Centrosome Cytosol Plasma Membrane Vesicle Stereocilium Stereocilium Bundle Stereocilium Tip Ruffle Membrane Protein-containing Complex Cell Projection Organelle Extracellular Exosome
	Molecular Function	Transcription Coactivator Binding RNA Binding Structural Constituent Of Ribosome Protein Binding Ubiquitin Protein Ligase Binding Large Ribosomal Subunit RRNA Binding Ubiquitin Ligase Inhibitor Activity	Actin Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Cadherin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cytoplasmic Translation Translation Ribosomal Protein Import Into Nucleus Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Protein-DNA Complex Disassembly Protein Stabilization G1 To G0 Transition Cellular Response To Actinomycin D Positive Regulation Of Signal Transduction By P53 Class Mediator Regulation Of G1 To G0 Transition Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Rho Protein Signal Transduction Sensory Perception Of Sound Regulation Of Rho Protein Signal Transduction Positive Regulation Of Ruffle Assembly
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs		(S)-3-phenyllactic acid Anisomycin Puromycin
Diseases
GWAS		Chronic obstructive pulmonary disease ( 30804561)	Keratoconus ( 33649486)
Interacting Genes		17 interacting genes: APP BCCIP CDC42 CLU DAPP1 DUX4 EPS8L2 FNDC3B GRWD1 IPO5 ISG15 MEOX2 NAP1L1 PTEN RELA SNRPA UBC	9 interacting genes: APP PTK2 RIN3 RPL23 SASH1 SOS1 TNS2 TRIM55 TRIM63
Entrez ID		9349	64787
HPRD ID		04716	10940
Ensembl ID		ENSG00000125691	ENSG00000177106
Uniprot IDs		P62829	Q9H6S3
PDB IDs		4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7F5S 7OW7 7XNX 7XNY 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO	1WWU 1WXB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Amyloid Precursor Protein Catabolic Process Central Nervous System Myelin Maintenance Neuron Projection Organization Positive Regulation Of Amyloid Fibril Formation Regulation Of Amyloid Precursor Protein Catabolic Process Protein-containing Complex Cytoplasm Myelin Maintenance Protein Tag Activity Regulation Of Amyloid Fibril Formation Regulation Of Amyloid-beta Clearance Cytosol Dendritic Spine Morphogenesis Positive Regulation Of Amyloid-beta Formation Ubiquitin Protein Ligase Binding Negative Regulation Of MiRNA Transcription Low-density Lipoprotein Particle Receptor Binding Microglial Cell Activation Positive Regulation Of Amide Metabolic Process RNA Binding Positive Regulation Of Excitatory Postsynaptic Potential Reproductive Behavior Leukocyte Activation Involved In Inflammatory Response Dendritic Spine Organization Positive Regulation Of Endocytosis Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Cell Population Proliferation Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Proteolysis Amyloid-beta Complex Growth Cone Lamellipodium Intracellular Signal Transduction Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Innate Immune Response Chromatin Binding Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Nitric Oxide Metabolic Process Postsynapse Organization Perinuclear Endoplasmic Reticulum Lumen Regulation Of Amyloid-beta Formation Regulation Of Neuronal Signal Transduction Negative Regulation Of Synaptic Vesicle Clustering Nucleus Intracellular Signaling Cassette Positive Regulation Of Receptor-mediated Endocytosis Acetylcholine Receptor Activator Activity Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cytokine Production	Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Molecular Function Activator Activity Regulation Of Phosphorus Metabolic Process Protein Metabolic Process Regulation Of Chemotaxis Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Leukocyte Migration Amyloid-beta Complex Positive Regulation Of Phosphate Metabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Cell Communication Cytoplasm Glial Cell Development Regulation Of Signaling Fc Receptor Signaling Pathway Heart Morphogenesis Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Mast Cell Chemotaxis Regulation Of Epithelial Cell Migration Regulation Of ATP Metabolic Process Regulation Of Receptor Internalization Protein Modification Process ERBB Signaling Pathway Developmental Growth Response To Interleukin-1 Regulation Of Cell Population Proliferation Regulation Of Purine Nucleotide Metabolic Process Regulation Of Proteolysis Acetylcholine Receptor Activator Activity Positive Regulation Of Mononuclear Cell Migration Regulation Of Cell Migration Positive Regulation Of Leukocyte Chemotaxis Lipoprotein Particle Positive Regulation Of Protein Import Protein Tyrosine Phosphatase Activity GTPase Complex Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Focal Adhesion PTB Domain Binding
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