GTF3C5 and GTF3C3

Number of citations of the paper that reports this interaction (PubMedID 37761933)
99

Data Source:
BioGRID (affinity chromatography technology, biochemical, affinity chromatography technology)
HPRD (in vitro, in vivo)

		GTF3C5	GTF3C3
Description		general transcription factor IIIC subunit 5	general transcription factor IIIC subunit 3
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GO Annotations	Cellular Component	Transcription Factor TFIIIC Complex Nucleus Nucleoplasm	Transcription Factor TFIIIC Complex Fibrillar Center Nucleus Nucleoplasm Nuclear Membrane
	Molecular Function	RNA Polymerase III General Transcription Initiation Factor Activity RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding DNA Binding Protein Binding	RNA Polymerase III General Transcription Initiation Factor Activity DNA Binding Protein Binding
	Biological Process	Transcription By RNA Polymerase III Transcription Initiation At RNA Polymerase III Promoter Skeletal Muscle Cell Differentiation 5S Class RRNA Transcription By RNA Polymerase III TRNA Transcription By RNA Polymerase III	Transcription By RNA Polymerase III 5S Class RRNA Transcription By RNA Polymerase III TRNA Transcription By RNA Polymerase III
Pathways		RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter	RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter
Drugs
Diseases
GWAS		Sepsis (28-day mortality) ( 32592749)
Interacting Genes		16 interacting genes: BRF1 DNMT3L GTF3C3 GTF3C4 KRT40 KRTAP10-3 KRTAP12-3 MDFI NOTCH2NLA OGT PTEN RPTOR SRA1 TBP TCF21 TCF4	11 interacting genes: BRF1 DEDD DEDD2 GTF3C5 HNRNPD NEDD8 PCBD1 PTEN SMARCAD1 TBP UBC
Entrez ID		9328	9330
HPRD ID		16077	11997
Ensembl ID		ENSG00000148308	ENSG00000119041
Uniprot IDs		H7BY84 Q9Y5Q8	Q9Y5Q9
PDB IDs		8CLK	8CLK
Enriched GO Terms of Interacting Partners?		RNA Polymerase III General Transcription Initiation Factor Activity Transcription By RNA Polymerase III TRNA Transcription RRNA Transcription TFIIB-class Transcription Factor Binding Transcription Factor TFIIIC Complex 5S Class RRNA Transcription By RNA Polymerase III Transcription Initiation At RNA Polymerase III Promoter DNA-templated Transcription Initiation TRNA Transcription By RNA Polymerase III Keratin Filament Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Intermediate Filament RRNA Metabolic Process DNA-templated Transcription TRNA Metabolic Process Protein-DNA Complex Assembly Macromolecule Biosynthetic Process Transcription Preinitiation Complex Assembly Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Synaptic Vesicle Clustering Social Behavior Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Positive Regulation Of Macromolecule Biosynthetic Process E-box Binding Protein Localization To Lysosome Protein N-acetylglucosaminyltransferase Complex Cellular Response To Glucose Stimulus Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Positive Regulation Of TORC1 Signaling Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation TORC1 Signaling Steroid Receptor RNA Activator RNA Binding Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Regulation Of ATP Metabolic Process Cellular Response To Carbohydrate Stimulus Transcription Factor TFIIIB Complex Cellular Developmental Process	RNA Polymerase III General Transcription Initiation Factor Activity Nucleoplasm Transcription By RNA Polymerase III Nucleus Transcription Initiation At RNA Polymerase III Promoter DNA-templated Transcription Initiation TRNA Transcription Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Tag Activity Regulation Of RNA Metabolic Process Macromolecule Metabolic Process RRNA Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process RNA Metabolic Process Response To Electrical Stimulus Regulation Of Transcription By RNA Polymerase I Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors RRNA Metabolic Process Nucleobase-containing Compound Metabolic Process Hepatocyte Dedifferentiation Cellular Response To Putrescine Negative Regulation Of Synaptic Vesicle Clustering U11/U12 SnRNP Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Transcription Preinitiation Complex Assembly Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Circadian Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Tyrosine Biosynthetic Process Phenylalanine 4-monooxygenase Activity Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity DNA Binding Transcription Factor TFIIIB Complex Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process
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