THRB and PPARGC1B

Number of citations of the paper that reports this interaction (PMID 11733490)
123

Data Source:
BioGRID (pull down)

		THRB	PPARGC1B
Gene Name		thyroid hormone receptor, beta	peroxisome proliferator-activated receptor gamma, coactivator 1 beta
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Extracellular Vesicular Exosome	Nucleus Nucleoplasm Mitochondrion Mediator Complex
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Corepressor Activity Thyroid Hormone Receptor Activity Protein Binding Zinc Ion Binding Enzyme Binding Chromatin DNA Binding Sequence-specific DNA Binding Thyroid Hormone Binding	Nucleotide Binding RNA Polymerase II Transcription Cofactor Activity RNA Binding Transcription Factor Binding Estrogen Receptor Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Receptor Activator Activity AF-2 Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Sensory Perception Of Sound Negative Regulation Of Female Receptivity Regulation Of Heart Contraction Female Courtship Behavior Organ Morphogenesis Gene Expression Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Type I Pneumocyte Differentiation	Ossification Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription From Mitochondrial Promoter Organelle Organization Mitochondrion Organization Actin Filament Organization Positive Regulation Of Alkaline Phosphatase Activity Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Reactive Oxygen Species Positive Regulation Of Phosphorylation Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Bone Resorption Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Glucocorticoid Response To CAMP Bone Trabecula Formation Positive Regulation Of Receptor Activity
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway	PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis Mitochondrial biogenesis
Drugs		Liothyronine Levothyroxine Dextrothyroxine Liotrix [3,5-Dibromo-4-(4-Hydroxy-3-Phenethylcarbamoyl-Phenoxy)-Phenyl]-Acetic Acid 3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid 2-[4-(4-Hydroxy-3-Isopropyl-Phenoxy)-3,5-Dimethyl-Phenyl]-2h-[1,2,4]Triazine-3,5-Dione [4-(4-Hydroxy-3-Iodo-Phenoxy)-3,5-Diiodo-Phenyl]-Acetic Acid GC-24 {4-[4-hydroxy-3-(1-methylethyl)benzyl]-3,5-dimethylphenoxy}acetic acid 1-(4-HEXYLPHENYL)PROP-2-EN-1-ONE
Diseases
GWAS		Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 20139978) Red blood cell traits ( 23222517)	Obesity-related traits ( 23251661) Tanning ( 19340012)
Protein-Protein Interactions		58 interactors: ACVR1 ADAT3 ANP32A ATF2 BRD8 BTG1 C1D CAMK2B CCND1 CNOT1 COPS2 CTCF EIF3I ESR1 FOXO1 HDAC2 HDAC3 HMGN3 JMJD1C LRIF1 MECR MED1 MED21 MMS19 MPG NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NR2F6 NRBF2 NRIP1 NSD1 PPARGC1A PPARGC1B PRKDC PRMT1 PRMT2 PSMC3IP PSMC5 RANBP9 RARA ROBO4 RXRA RXRB RXRG SRC TBL1X TP53 TRIP10 TRIP12 TRIP13 TRIP4 TRIP6 TSG101 ZNHIT3	13 interactors: AKT1 ESR1 ESRRG HCFC1 HNF4A PPARA SRC THRB ZBTB9 ZFP64 ZNF200 ZNF212 ZNF513
Entrez ID		7068	133522
HPRD ID		07521	10594
Ensembl ID		ENSG00000151090	ENSG00000155846
Uniprot IDs		F1D8N7 P10828	B7ZM40 Q86YN6
PDB IDs		1BSX 1N46 1NAX 1NQ0 1NQ1 1NQ2 1NUO 1Q4X 1R6G 1XZX 1Y0X 2J4A 2NLL 2PIN 3D57 3GWS 3IMY 3JZC	3SP6
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Intracellular Receptor Signaling Pathway RNA Metabolic Process Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Nitrogen Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Chromatin Organization Chromosome Organization Transcription Initiation From RNA Polymerase II Promoter Response To Hormone Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Positive Regulation Of Metabolic Process Chromatin Modification Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Hormone Stimulus Signal Transduction Regulation Of Cellular Process Cellular Response To Stimulus Response To Steroid Hormone	Cellular Response To Steroid Hormone Stimulus Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Intracellular Receptor Signaling Pathway Transcription, DNA-templated Cellular Response To Organic Cyclic Compound RNA Biosynthetic Process Gene Expression Regulation Of Gene Expression Steroid Hormone Mediated Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Hormone-mediated Signaling Pathway Cellular Response To Hormone Stimulus Positive Regulation Of Gene Expression RNA Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Lipid Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Response To Steroid Hormone DNA-templated Transcription, Initiation Response To Organic Cyclic Compound Response To Hormone Positive Regulation Of Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Lipid Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Regulation Of Lipid Metabolic Process Cellular Metabolic Process Mammary Gland Epithelium Development Cellular Response To Organic Substance Regulation Of Glucose Metabolic Process Uterus Development Regulation Of Fatty Acid Beta-oxidation Intracellular Estrogen Receptor Signaling Pathway
Tagcloud ?		approximate bank carrying circular clarke clockwise ecori enabled endonuclease hybird kilobase kilobases lacz lambda limitation maxicell pbr322 phage pho phom phou plac plasmid plasmids plc17 regulon subcloned threefold transcribed	17beta abundantly biased coagulation constituted dimorphic dimorphism etc feminized hnf4a insensitive keto kt11 livers lxr metabolisms mycn oviparous retinol sage sexes spawning stat4 transcriptomes transcriptomic vitellogenin viviparous xenobiotic zebrafish
Tagcloud (Difference) ?		approximate bank carrying circular clarke clockwise ecori enabled endonuclease hybird kilobase kilobases lacz lambda limitation maxicell pbr322 phage pho phom phou plac plasmid plasmids plc17 regulon subcloned threefold transcribed	17beta abundantly biased coagulation constituted dimorphic dimorphism etc feminized hnf4a insensitive keto kt11 livers lxr metabolisms mycn oviparous retinol sage sexes spawning stat4 transcriptomes transcriptomic vitellogenin viviparous xenobiotic zebrafish
Tagcloud (Intersection) ?