THRB and JMJD1C

Number of citations of the paper that reports this interaction (PMID 7776974)
105

Data Source:
HPRD (two hybrid)

		THRB	JMJD1C
Gene Name		thyroid hormone receptor, beta	jumonji domain containing 1C
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Extracellular Vesicular Exosome	Intracellular Nucleoplasm
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Corepressor Activity Thyroid Hormone Receptor Activity Protein Binding Zinc Ion Binding Enzyme Binding Chromatin DNA Binding Sequence-specific DNA Binding Thyroid Hormone Binding	Protein Binding Metal Ion Binding Thyroid Hormone Receptor Binding Dioxygenase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Sensory Perception Of Sound Negative Regulation Of Female Receptivity Regulation Of Heart Contraction Female Courtship Behavior Organ Morphogenesis Gene Expression Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Type I Pneumocyte Differentiation	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Blood Coagulation Chromatin Modification Oxidation-reduction Process
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway	Factors involved in megakaryocyte development and platelet production
Drugs		Liothyronine Levothyroxine Dextrothyroxine Liotrix [3,5-Dibromo-4-(4-Hydroxy-3-Phenethylcarbamoyl-Phenoxy)-Phenyl]-Acetic Acid 3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid 2-[4-(4-Hydroxy-3-Isopropyl-Phenoxy)-3,5-Dimethyl-Phenyl]-2h-[1,2,4]Triazine-3,5-Dione [4-(4-Hydroxy-3-Iodo-Phenoxy)-3,5-Diiodo-Phenyl]-Acetic Acid GC-24 {4-[4-hydroxy-3-(1-methylethyl)benzyl]-3,5-dimethylphenoxy}acetic acid 1-(4-HEXYLPHENYL)PROP-2-EN-1-ONE
Diseases
GWAS		Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 20139978) Red blood cell traits ( 23222517)	Androgen levels ( 22936694) Arthritis (juvenile idiopathic) ( 22354554) Liver enzyme levels ( 18940312) Liver enzyme levels (alkaline phosphatase) ( 22001757) Mean platelet volume ( 22139419 19820697 22423221) Platelet aggregation ( 20526338) Platelet counts ( 22139419 23263863) Sex hormone-binding globulin levels ( 22829776) Triglycerides ( 20686565)
Protein-Protein Interactions		58 interactors: ACVR1 ADAT3 ANP32A ATF2 BRD8 BTG1 C1D CAMK2B CCND1 CNOT1 COPS2 CTCF EIF3I ESR1 FOXO1 HDAC2 HDAC3 HMGN3 JMJD1C LRIF1 MECR MED1 MED21 MMS19 MPG NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NR2F6 NRBF2 NRIP1 NSD1 PPARGC1A PPARGC1B PRKDC PRMT1 PRMT2 PSMC3IP PSMC5 RANBP9 RARA ROBO4 RXRA RXRB RXRG SRC TBL1X TP53 TRIP10 TRIP12 TRIP13 TRIP4 TRIP6 TSG101 ZNHIT3	12 interactors: AR ESR2 GADD45A MT2A NUDT21 PPARG PSMC1 RNF168 RNF8 RXRA THRB TK1
Entrez ID		7068	221037
HPRD ID		07521	05141
Ensembl ID		ENSG00000151090	ENSG00000171988
Uniprot IDs		F1D8N7 P10828	Q15652
PDB IDs		1BSX 1N46 1NAX 1NQ0 1NQ1 1NQ2 1NUO 1Q4X 1R6G 1XZX 1Y0X 2J4A 2NLL 2PIN 3D57 3GWS 3IMY 3JZC	2YPD
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Intracellular Receptor Signaling Pathway RNA Metabolic Process Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Nitrogen Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Chromatin Organization Chromosome Organization Transcription Initiation From RNA Polymerase II Promoter Response To Hormone Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Positive Regulation Of Metabolic Process Chromatin Modification Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Hormone Stimulus Signal Transduction Regulation Of Cellular Process Cellular Response To Stimulus Response To Steroid Hormone	Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Intracellular Receptor Signaling Pathway Response To Steroid Hormone DNA-templated Transcription, Initiation Histone H2A K63-linked Ubiquitination Cellular Nitrogen Compound Metabolic Process Cellular Response To Organic Cyclic Compound Negative Regulation Of Transcription From RNA Polymerase II Promoter Reproductive Process Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Response To Lipid Negative Regulation Of Cellular Metabolic Process Response To Lipid Transcription From RNA Polymerase II Promoter Response To Organic Cyclic Compound Response To Hormone Peroxisome Proliferator Activated Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Prostate Gland Development Cellular Response To Hormone Stimulus Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Interstrand Cross-link Repair Single Organism Reproductive Process Developmental Process Involved In Reproduction Protein Tetramerization Negative Regulation Of Gene Expression Histone H2A Ubiquitination Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Epithelial Cell Differentiation Involved In Prostate Gland Development Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of DNA-templated Transcription, Elongation Response To Ionizing Radiation Protein Oligomerization Positive Regulation Of Metabolic Process Response To Stimulus Response To Organic Substance Protein Polyubiquitination Reproductive Structure Development Isotype Switching
Tagcloud ?		approximate bank carrying circular clarke clockwise ecori enabled endonuclease hybird kilobase kilobases lacz lambda limitation maxicell pbr322 phage pho phom phou plac plasmid plasmids plc17 regulon subcloned threefold transcribed	catalyze chip cofactors confirms demethylase demethylation depletion differentiated dnmt3a enhancer fact h3k9me2 identifies incompletely nanog newly nucleosome oct4 opposes pluripotency pou5f1 recruitment recruits reprogram sequentially stepwise synthesized timecourse whereby
Tagcloud (Difference) ?		approximate bank carrying circular clarke clockwise ecori enabled endonuclease hybird kilobase kilobases lacz lambda limitation maxicell pbr322 phage pho phom phou plac plasmid plasmids plc17 regulon subcloned threefold transcribed	catalyze chip cofactors confirms demethylase demethylation depletion differentiated dnmt3a enhancer fact h3k9me2 identifies incompletely nanog newly nucleosome oct4 opposes pluripotency pou5f1 recruitment recruits reprogram sequentially stepwise synthesized timecourse whereby
Tagcloud (Intersection) ?