THRB and MMS19

Number of citations of the paper that reports this interaction (PMID 11279242)
21

Data Source:
BioGRID (pull down)

		THRB	MMS19
Gene Name		thyroid hormone receptor, beta	MMS19 nucleotide excision repair homolog (S. cerevisiae)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Extracellular Vesicular Exosome	Nucleus Nucleoplasm Holo TFIIH Complex Cytoplasm Spindle Membrane MMXD Complex CIA Complex
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Corepressor Activity Thyroid Hormone Receptor Activity Protein Binding Zinc Ion Binding Enzyme Binding Chromatin DNA Binding Sequence-specific DNA Binding Thyroid Hormone Binding	Transcription Coactivator Activity Protein Binding Receptor Signaling Complex Scaffold Activity Estrogen Receptor Binding Protein Binding, Bridging
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Sensory Perception Of Sound Negative Regulation Of Female Receptivity Regulation Of Heart Contraction Female Courtship Behavior Organ Morphogenesis Gene Expression Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Type I Pneumocyte Differentiation	Phosphorelay Signal Transduction System DNA Metabolic Process DNA Repair Nucleotide-excision Repair Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Chromosome Segregation Response To Hormone Iron-sulfur Cluster Assembly Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway	Cytosolic iron-sulfur cluster assembly
Drugs		Liothyronine Levothyroxine Dextrothyroxine Liotrix [3,5-Dibromo-4-(4-Hydroxy-3-Phenethylcarbamoyl-Phenoxy)-Phenyl]-Acetic Acid 3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid 2-[4-(4-Hydroxy-3-Isopropyl-Phenoxy)-3,5-Dimethyl-Phenyl]-2h-[1,2,4]Triazine-3,5-Dione [4-(4-Hydroxy-3-Iodo-Phenoxy)-3,5-Diiodo-Phenyl]-Acetic Acid GC-24 {4-[4-hydroxy-3-(1-methylethyl)benzyl]-3,5-dimethylphenoxy}acetic acid 1-(4-HEXYLPHENYL)PROP-2-EN-1-ONE
Diseases
GWAS		Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 20139978) Red blood cell traits ( 23222517)
Protein-Protein Interactions		58 interactors: ACVR1 ADAT3 ANP32A ATF2 BRD8 BTG1 C1D CAMK2B CCND1 CNOT1 COPS2 CTCF EIF3I ESR1 FOXO1 HDAC2 HDAC3 HMGN3 JMJD1C LRIF1 MECR MED1 MED21 MMS19 MPG NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NR2F6 NRBF2 NRIP1 NSD1 PPARGC1A PPARGC1B PRKDC PRMT1 PRMT2 PSMC3IP PSMC5 RANBP9 RARA ROBO4 RXRA RXRB RXRG SRC TBL1X TP53 TRIP10 TRIP12 TRIP13 TRIP4 TRIP6 TSG101 ZNHIT3	6 interactors: ESR1 ESR2 GTF2H1 NCOA3 RARA THRB
Entrez ID		7068	64210
HPRD ID		07521	17579
Ensembl ID		ENSG00000151090	ENSG00000155229
Uniprot IDs		F1D8N7 P10828	Q96T76
PDB IDs		1BSX 1N46 1NAX 1NQ0 1NQ1 1NQ2 1NUO 1Q4X 1R6G 1XZX 1Y0X 2J4A 2NLL 2PIN 3D57 3GWS 3IMY 3JZC
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Intracellular Receptor Signaling Pathway RNA Metabolic Process Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Nitrogen Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Chromatin Organization Chromosome Organization Transcription Initiation From RNA Polymerase II Promoter Response To Hormone Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Positive Regulation Of Metabolic Process Chromatin Modification Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Hormone Stimulus Signal Transduction Regulation Of Cellular Process Cellular Response To Stimulus Response To Steroid Hormone	Transcription Initiation From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Intracellular Steroid Hormone Receptor Signaling Pathway Vagina Development Steroid Hormone Mediated Signaling Pathway Intracellular Estrogen Receptor Signaling Pathway Female Genitalia Development Hormone-mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus Cellular Response To Hormone Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Genitalia Development Sex Differentiation Transcription From RNA Polymerase II Promoter Prostate Gland Development Response To Hormone Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Cellular Response To Organic Cyclic Compound RNA Biosynthetic Process Epithelium Development Cellular Response To Lipid Response To Steroid Hormone Gland Development Reproductive Structure Development Reproductive System Development Morphogenesis Of An Epithelium Reproductive Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Epithelial Cell Differentiation Uterus Development Gland Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Tissue Morphogenesis Gene Expression Tube Development Tissue Development Developmental Process Involved In Reproduction Epithelial Cell Development Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Gonad Development Cellular Response To Organic Substance Development Of Primary Sexual Characteristics
Tagcloud ?		approximate bank carrying circular clarke clockwise ecori enabled endonuclease hybird kilobase kilobases lacz lambda limitation maxicell pbr322 phage pho phom phou plac plasmid plasmids plc17 regulon subcloned threefold transcribed	ahead cdc20 clr4 clr7 clr8 dos1 dos2 euchromatin fission fork h3k9 heterochromatic heterochromatin hp1 lid2 marks metazoan pombe raf1 raf2 rdrc reassembled refs rik1 rits schizosaccharomyces shedding sirnas swi6
Tagcloud (Difference) ?		approximate bank carrying circular clarke clockwise ecori enabled endonuclease hybird kilobase kilobases lacz lambda limitation maxicell pbr322 phage pho phom phou plac plasmid plasmids plc17 regulon subcloned threefold transcribed	ahead cdc20 clr4 clr7 clr8 dos1 dos2 euchromatin fission fork h3k9 heterochromatic heterochromatin hp1 lid2 marks metazoan pombe raf1 raf2 rdrc reassembled refs rik1 rits schizosaccharomyces shedding sirnas swi6
Tagcloud (Intersection) ?