THRB and PPARGC1A

Number of citations of the paper that reports this interaction (PMID 11751919)
22

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		THRB	PPARGC1A
Gene Name		thyroid hormone receptor, beta	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Extracellular Vesicular Exosome	Nucleus Nucleoplasm DNA-directed RNA Polymerase II, Core Complex Cytosol PML Body
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Corepressor Activity Thyroid Hormone Receptor Activity Protein Binding Zinc Ion Binding Enzyme Binding Chromatin DNA Binding Sequence-specific DNA Binding Thyroid Hormone Binding	Nucleotide Binding RNA Polymerase II Transcription Cofactor Activity DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Transcription Factor Binding Ligand-dependent Nuclear Receptor Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Chromatin DNA Binding Ubiquitin Protein Ligase Binding Sequence-specific DNA Binding Androgen Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Sensory Perception Of Sound Negative Regulation Of Female Receptivity Regulation Of Heart Contraction Female Courtship Behavior Organ Morphogenesis Gene Expression Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Type I Pneumocyte Differentiation	Temperature Homeostasis Cellular Glucose Homeostasis Galactose Metabolic Process Gluconeogenesis Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter MRNA Processing Protein Complex Assembly Organelle Organization Mitochondrion Organization Digestion Circadian Rhythm Androgen Metabolic Process RNA Splicing Response To Cold Positive Regulation Of Mitochondrion Organization Response To Muscle Activity Fatty Acid Oxidation Respiratory Electron Transport Chain Androgen Receptor Signaling Pathway Circadian Regulation Of Gene Expression Cellular Response To Oxidative Stress Positive Regulation Of Histone Acetylation Response To Statin Response To Starvation Regulation Of Circadian Rhythm Response To Leucine Negative Regulation Of Neuron Apoptotic Process Cellular Respiration Positive Regulation Of Gluconeogenesis Negative Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fatty Acid Oxidation Positive Regulation Of Smooth Muscle Cell Proliferation Protein Stabilization Brown Fat Cell Differentiation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Flavone Metabolic Process Cellular Response To Nitrite Cellular Response To Tumor Necrosis Factor Cellular Response To Fatty Acid Cellular Response To Hypoxia Response To Epinephrine Response To Norepinephrine Cellular Response To Thyroid Hormone Stimulus Negative Regulation Of Neuron Death Positive Regulation Of Cellular Respiration Positive Regulation Of Mitochondrial DNA Metabolic Process Positive Regulation Of Muscle Tissue Development Negative Regulation Of Receptor Activity Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Positive Regulation Of Energy Homeostasis Positive Regulation Of ATP Biosynthetic Process
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway	PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins REV-ERBA represses gene expression RORA activates circadian gene expression Mitochondrial biogenesis Activation of PPARGC1A (PGC-1alpha) by phosphorylation Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs		Liothyronine Levothyroxine Dextrothyroxine Liotrix [3,5-Dibromo-4-(4-Hydroxy-3-Phenethylcarbamoyl-Phenoxy)-Phenyl]-Acetic Acid 3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid 2-[4-(4-Hydroxy-3-Isopropyl-Phenoxy)-3,5-Dimethyl-Phenyl]-2h-[1,2,4]Triazine-3,5-Dione [4-(4-Hydroxy-3-Iodo-Phenoxy)-3,5-Diiodo-Phenyl]-Acetic Acid GC-24 {4-[4-hydroxy-3-(1-methylethyl)benzyl]-3,5-dimethylphenoxy}acetic acid 1-(4-HEXYLPHENYL)PROP-2-EN-1-ONE
Diseases
GWAS		Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 20139978) Red blood cell traits ( 23222517)	Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		58 interactors: ACVR1 ADAT3 ANP32A ATF2 BRD8 BTG1 C1D CAMK2B CCND1 CNOT1 COPS2 CTCF EIF3I ESR1 FOXO1 HDAC2 HDAC3 HMGN3 JMJD1C LRIF1 MECR MED1 MED21 MMS19 MPG NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NR2F6 NRBF2 NRIP1 NSD1 PPARGC1A PPARGC1B PRKDC PRMT1 PRMT2 PSMC3IP PSMC5 RANBP9 RARA ROBO4 RXRA RXRB RXRG SRC TBL1X TP53 TRIP10 TRIP12 TRIP13 TRIP4 TRIP6 TSG101 ZNHIT3	40 interactors: CAPNS1 CDK6 CREBBP CREBZF ESR1 ESR2 ESRRA ESRRG FBXW7 GSK3B HCFC1 HNF4A LRPPRC MAPK14 MED1 MED12 MED14 MED17 MYBBP1A NCL NCOA1 NCOA6 NR1H4 NR1I2 NR1I3 NR3C1 NRF1 PPARA PPARD PPARG RXRA SIRT1 SRSF4 SRSF5 SRSF6 THRB TP53 UBC UBE2I USF2
Entrez ID		7068	10891
HPRD ID		07521	05155
Ensembl ID		ENSG00000151090	ENSG00000109819
Uniprot IDs		F1D8N7 P10828	I3RTT5 I3RTT6 Q9UBK2
PDB IDs		1BSX 1N46 1NAX 1NQ0 1NQ1 1NQ2 1NUO 1Q4X 1R6G 1XZX 1Y0X 2J4A 2NLL 2PIN 3D57 3GWS 3IMY 3JZC	1XB7 3B1M 3CS8 3D24 3U9Q 3V9T 3V9V
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Intracellular Receptor Signaling Pathway RNA Metabolic Process Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Nitrogen Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Chromatin Organization Chromosome Organization Transcription Initiation From RNA Polymerase II Promoter Response To Hormone Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Positive Regulation Of Metabolic Process Chromatin Modification Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Hormone Stimulus Signal Transduction Regulation Of Cellular Process Cellular Response To Stimulus Response To Steroid Hormone	Transcription Initiation From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Hormone-mediated Signaling Pathway Steroid Hormone Mediated Signaling Pathway RNA Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Gene Expression Cellular Response To Steroid Hormone Stimulus Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Steroid Hormone Cellular Nitrogen Compound Metabolic Process Cellular Response To Lipid Biosynthetic Process Negative Regulation Of Gene Expression Nitrogen Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Response To Organic Cyclic Compound Regulation Of Metabolic Process Response To Hormone Negative Regulation Of Biosynthetic Process Response To Lipid Cellular Response To Hormone Stimulus Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Organic Cyclic Compound Cellular Response To Organic Substance Response To Organic Substance
Tagcloud ?		approximate bank carrying circular clarke clockwise ecori enabled endonuclease hybird kilobase kilobases lacz lambda limitation maxicell pbr322 phage pho phom phou plac plasmid plasmids plc17 regulon subcloned threefold transcribed	ageing bisulfite chosen coefficients concordance cord d4z4 environage epigenetics foetal loop methylation mitochondrial mt nineteen ninety placenta placental pyrosequencing ranging reproductive rnr1 scheme sides signature sirt1 subtelomeric tfam
Tagcloud (Difference) ?		approximate bank carrying circular clarke clockwise ecori enabled endonuclease hybird kilobase kilobases lacz lambda limitation maxicell pbr322 phage pho phom phou plac plasmid plasmids plc17 regulon subcloned threefold transcribed	ageing bisulfite chosen coefficients concordance cord d4z4 environage epigenetics foetal loop methylation mitochondrial mt nineteen ninety placenta placental pyrosequencing ranging reproductive rnr1 scheme sides signature sirt1 subtelomeric tfam
Tagcloud (Intersection) ?