IGSF8 and TGM1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		IGSF8	TGM1
Description		immunoglobulin superfamily member 8	transglutaminase 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Presynaptic Membrane Extracellular Exosome Hippocampal Mossy Fiber To CA3 Synapse	Cornified Envelope Cytosol Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Protein Binding Signaling Receptor Activity	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Single Fertilization Nervous System Development Skeletal Muscle Tissue Development Positive Regulation Of Cell Migration Cell Motility Regulation Of Cell Motility	Positive Regulation Of Keratinocyte Proliferation Peptide Cross-linking Keratinocyte Differentiation Keratinization Protein Modification Process Cell Envelope Organization Positive Regulation Of Cell Cycle Animal Organ Development
Pathways			Formation of the cornified envelope
Drugs
Diseases			Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
GWAS
Interacting Genes		18 interacting genes: A2M CD81 CD82 CD9 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-4 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP2-3 KRTAP2-4 KRTAP4-12 KRTAP5-7 NBPF19 NOTCH2NLA TGM1	34 interacting genes: ACADL ALPP C1QTNF1 CNNM3 CRCT1 CXCL16 DOCK2 GSTP1 HSPB1 IFI30 IGSF8 ITGB4 JOSD1 KRTAP4-12 KRTAP5-9 LCE1B LCE1E LCE3A LCE4A MDK MYPOP NECTIN2 NUBP2 PLAAT4 RIN3 SCARF1 SEMG1 SEMG2 SNCA SULT4A1 TACC2 TRAPPC14 VASN VSTM4
Entrez ID		93185	7051
HPRD ID		09438	01824
Ensembl ID		ENSG00000162729	ENSG00000092295
Uniprot IDs		Q969P0	P22735
PDB IDs			2XZZ
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Myoblast Fusion Involved In Skeletal Muscle Regeneration Cellular Response To Lipoprotein Particle Stimulus Myoblast Fusion Regulation Of Mononuclear Cell Migration Cell-cell Fusion Cellular Response To Low-density Lipoprotein Particle Stimulus Syncytium Formation Syncytium Formation By Plasma Membrane Fusion Macrophage Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Regulation Of Macrophage Migration	Epidermis Development Negative Regulation Of Flagellated Sperm Motility Positive Regulation Of Serine-type Endopeptidase Activity Keratinization Positive Regulation Of Endopeptidase Activity Regulation Of Locomotion Endocytosis Positive Regulation Of Peptidase Activity
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