HECTD3

Gene Name		HECT domain containing E3 ubiquitin protein ligase 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity Syntaxin Binding
	Biological Process	Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-protein Interactions		5 interactors: BRCA1 CASP8 TP53 TRIOBP ZDHHC17
Entrez ID		79654
HPRD ID		13383
Ensembl ID		ENSG00000126107
Uniprot IDs		A1A4G1 B3KU34 Q5T447
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Regulation Of Thymocyte Apoptotic Process DNA Damage Response, Signal Transduction Resulting In Transcription Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Organelle Organization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of T Cell Apoptotic Process Apoptotic Signaling Pathway Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Organelle Organization Response To Antibiotic Positive Regulation Of Mitochondrion Organization Regulation Of Lymphocyte Apoptotic Process Positive Regulation Of Histone Modification Positive Regulation Of Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Signal Transduction In Response To DNA Damage Regulation Of Mitochondrion Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Cell Cycle Arrest Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Actin Modification Regulation Of Cellular Component Organization Signal Transduction By P53 Class Mediator Regulation Of Histone Modification Response To Tumor Necrosis Factor Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Response To Ionizing Radiation Double-strand Break Repair Positive Regulation Of Intracellular Signal Transduction DNA Damage Checkpoint Negative Regulation Of Macromitophagy Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Positive Regulation Of Histone H3-K9 Acetylation Oligodendrocyte Apoptotic Process Regulation Of Reactive Oxygen Species Metabolic Process B Cell Activation Negative Regulation Of Cytoskeleton Organization Response To Toxic Substance Negative Regulation Of Programmed Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Helicase Activity Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation TRAIL-activated Apoptotic Signaling Pathway Apoptotic Process
Tagcloud ?		actin actually associates bona centrosomal cooperation cytoskeletal delay depended e3 facilitates faithful fide hela ligases mitosis mitotic phosphorylatable phosphorylates plk1 polo repeat segregation tara telomeric thr trf1 trio