HECTD3 and UBE2S

Number of citations of the paper that reports this interaction (PubMedID 33607208)
0

Data Source:
BioGRID (pull down)

		HECTD3	UBE2S
Description		HECT domain E3 ubiquitin protein ligase 3	ubiquitin conjugating enzyme E2 S
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Anaphase-promoting Complex Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Syntaxin Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Anaphase-promoting Complex Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Exit From Mitosis Free Ubiquitin Chain Polymerization Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein K29-linked Ubiquitination Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K27-linked Ubiquitination Cell Division Protein K63-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Interacting Genes		17 interacting genes: BRCA1 CASP8 CASP9 CHUK HSP90AA1 PARP1 PPL RAF1 TP53 TRIOBP UBE2A UBE2C UBE2D2 UBE2D3 UBE2Q2 UBE2S ZDHHC17	33 interacting genes: AKT1 ANAPC1 ANAPC11 ANAPC4 ANAPC5 ANAPC7 APP ATXN3 BIRC2 CDC16 CDC20 CDC23 CDC27 CYLD HECTD3 HERC1 LINC00839 MDM2 NFKBIA OTUB1 OTUD7B PRKN RBCK1 STAMBP UBA1 UBA6 UBB UBC UCHL3 USP2 USP21 USP5 USP7
Entrez ID		79654	27338
HPRD ID		13383	15603
Ensembl ID		ENSG00000126107	ENSG00000108106
Uniprot IDs		A1A4G1 B3KU34 Q5T447	Q16763
PDB IDs			1ZDN 5BNB 5L9T 6QH3 6QHK 6S96 6S98 7AHF 8TAU
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Metabolic Process Protein Polyubiquitination Ubiquitin Protein Ligase Binding Protein Modification Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Transferase Activity Macromolecule Metabolic Process Post-translational Protein Modification Ubiquitin-like Protein Transferase Activity Protein Ubiquitination Positive Regulation Of Execution Phase Of Apoptosis Protein K6-linked Ubiquitination ATP Binding Protein Modification By Small Protein Conjugation Protein-containing Complex Regulation Of Programmed Necrotic Cell Death Proteolysis Glial Cell Apoptotic Process Apoptotic Process Apoptotic Signaling Pathway Nucleotide Binding Response To Indole-3-methanol Response To Anesthetic Positive Regulation Of Ubiquitin Protein Ligase Activity Response To UV Programmed Cell Death Cell Death Mitochondrial DNA Repair Regulation Of Telomere Maintenance Via Telomere Lengthening Free Ubiquitin Chain Polymerization Cellular Response To Radiation Cytosol Response To Stress Proteolysis Involved In Protein Catabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Neuron Apoptotic Process Response To Cobalt Ion Protein Autoubiquitination Scaffold Protein Binding DNA Metabolic Process Response To Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Canonical NF-kappaB Signal Transduction Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Ubiquitin-protein Transferase Activity DNA Damage Response	Post-translational Protein Modification Proteolysis Protein Modification Process Protein Ubiquitination Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Anaphase-promoting Complex-dependent Catabolic Process Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Anaphase-promoting Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Macromolecule Catabolic Process Protein Deubiquitination Proteasomal Protein Catabolic Process Protein Modification By Small Protein Removal Protein Catabolic Process Protein Branched Polyubiquitination Protein Polyubiquitination Macromolecule Metabolic Process Catabolic Process Regulation Of Meiotic Cell Cycle Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Cysteine-type Deubiquitinase Activity Protein K48-linked Ubiquitination Regulation Of Sister Chromatid Segregation Positive Regulation Of Mitotic Metaphase/anaphase Transition Cytosol Positive Regulation Of Mitotic Sister Chromatid Separation Cysteine-type Peptidase Activity Regulation Of Chromosome Segregation Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Regulation Of Chromosome Organization Positive Regulation Of Chromosome Separation Positive Regulation Of Cell Cycle Phase Transition Regulation Of Reproductive Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Cell Cycle Regulation Of Mitotic Metaphase/anaphase Transition Metaphase/anaphase Transition Of Cell Cycle Ubiquitin Binding Ubiquitin-protein Transferase Activity Regulation Of Mitotic Sister Chromatid Separation Regulation Of Proteasomal Protein Catabolic Process Regulation Of Chromosome Separation Peptidase Activity Regulation Of Mitotic Cell Cycle Phase Transition
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