HECTD3 and TRIOBP

Number of citations of the paper that reports this interaction (PubMedID 18194665)
0

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology)

		HECTD3	TRIOBP
Description		HECT domain E3 ubiquitin protein ligase 3	TRIO and F-actin binding protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Perinuclear Region Of Cytoplasm	Chromosome, Telomeric Region Nucleus Chromosome Cytoplasm Centrosome Cytoskeleton Focal Adhesion Actin Cytoskeleton Midbody Stereocilium Base
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Syntaxin Binding Ubiquitin Protein Ligase Activity	Actin Binding Protein Binding Small GTPase Binding Ubiquitin Protein Ligase Binding Myosin II Binding Actin Filament Binding
	Biological Process	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Sensory Perception Of Sound Actin Modification Barbed-end Actin Filament Capping Cell Division Auditory Receptor Cell Stereocilium Organization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Adult hearing difficulty ( 31564434) Age-related hearing impairment ( 27764096 34108613) Age-related hearing impairment (low/mid frequency) ( 31645637) Basophil count ( 32888494) Brain morphology (MOSTest) ( 32665545) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 33627673) Intraocular pressure ( 29617998 29785010 30054594 31959993) Lateral ventricular volume in normal aging ( 30258056) Optic cup area ( 28073927 25631615) Pulse pressure ( 30224653) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		17 interacting genes: BRCA1 CASP8 CASP9 CHUK HSP90AA1 PARP1 PPL RAF1 TP53 TRIOBP UBE2A UBE2C UBE2D2 UBE2D3 UBE2Q2 UBE2S ZDHHC17	11 interacting genes: DSCR9 FXR1 FXR2 GTF2H1 HECTD3 IKBKG LCOR PLK1 POLR1C TSC1 VIM
Entrez ID		79654	11078
HPRD ID		13383	11028
Ensembl ID		ENSG00000126107	ENSG00000100106
Uniprot IDs		A1A4G1 B3KU34 Q5T447	Q9H2D6
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Metabolic Process Protein Polyubiquitination Ubiquitin Protein Ligase Binding Protein Modification Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Transferase Activity Macromolecule Metabolic Process Post-translational Protein Modification Ubiquitin-like Protein Transferase Activity Protein Ubiquitination Positive Regulation Of Execution Phase Of Apoptosis Protein K6-linked Ubiquitination ATP Binding Protein Modification By Small Protein Conjugation Protein-containing Complex Regulation Of Programmed Necrotic Cell Death Proteolysis Glial Cell Apoptotic Process Apoptotic Process Apoptotic Signaling Pathway Nucleotide Binding Response To Indole-3-methanol Response To Anesthetic Positive Regulation Of Ubiquitin Protein Ligase Activity Response To UV Programmed Cell Death Cell Death Mitochondrial DNA Repair Regulation Of Telomere Maintenance Via Telomere Lengthening Free Ubiquitin Chain Polymerization Cellular Response To Radiation Cytosol Response To Stress Proteolysis Involved In Protein Catabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Neuron Apoptotic Process Response To Cobalt Ion Protein Autoubiquitination Scaffold Protein Binding DNA Metabolic Process Response To Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Canonical NF-kappaB Signal Transduction Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Ubiquitin-protein Transferase Activity DNA Damage Response	Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Long-term Neuronal Synaptic Plasticity Transcription By RNA Polymerase I Translation Regulator Activity Dentate Gyrus Development Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of MRNA Stability Regulation Of RNA Stability Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Catabolic Process Memory T Cell Differentiation Regulation Of Neuronal Synaptic Plasticity
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