HECTD3 and TRIOBP

Number of citations of the paper that reports this interaction (PMID 18194665)
5

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology)

		HECTD3	TRIOBP
Gene Name		HECT domain containing E3 ubiquitin protein ligase 3	TRIO and F-actin binding protein
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Microtubule Organizing Center Focal Adhesion Actin Cytoskeleton Midbody
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity Syntaxin Binding	GTP-Rho Binding Ubiquitin Protein Ligase Binding Myosin II Binding Actin Filament Binding
	Biological Process	Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Mitotic Nuclear Division Actin Modification Barbed-end Actin Filament Capping Cell Division Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: BRCA1 CASP8 TP53 TRIOBP ZDHHC17	6 interactors: GTF2H1 HECTD3 IKBKG PLK1 POLR1C VIM
Entrez ID		79654	11078
HPRD ID		13383	11028
Ensembl ID		ENSG00000126107	ENSG00000100106
Uniprot IDs		A1A4G1 B3KU34 Q5T447	F8W6V6 Q9H2D6
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Regulation Of Thymocyte Apoptotic Process DNA Damage Response, Signal Transduction Resulting In Transcription Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Organelle Organization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of T Cell Apoptotic Process Apoptotic Signaling Pathway Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Organelle Organization Response To Antibiotic Positive Regulation Of Mitochondrion Organization Regulation Of Lymphocyte Apoptotic Process Positive Regulation Of Histone Modification Positive Regulation Of Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Signal Transduction In Response To DNA Damage Regulation Of Mitochondrion Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Cell Cycle Arrest Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Actin Modification Regulation Of Cellular Component Organization Signal Transduction By P53 Class Mediator Regulation Of Histone Modification Response To Tumor Necrosis Factor Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Response To Ionizing Radiation Double-strand Break Repair Positive Regulation Of Intracellular Signal Transduction DNA Damage Checkpoint Negative Regulation Of Macromitophagy Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Positive Regulation Of Histone H3-K9 Acetylation Oligodendrocyte Apoptotic Process Regulation Of Reactive Oxygen Species Metabolic Process B Cell Activation Negative Regulation Of Cytoskeleton Organization Response To Toxic Substance Negative Regulation Of Programmed Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Helicase Activity Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation TRAIL-activated Apoptotic Signaling Pathway Apoptotic Process	Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription From RNA Polymerase I Promoter DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Type I Interferon Production DNA-templated Transcription, Elongation Viral Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Type I Interferon Production Activation Of APC-Cdc20 Complex Activity Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Cellular Response To DNA Damage Stimulus Cellular Macromolecule Catabolic Process Polar Body Extrusion After Meiotic Divisions Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Initiation Regulation Of Protein Phosphorylation Activation Of Anaphase-promoting Complex Activity Meiotic Cytokinesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Bergmann Glial Cell Differentiation Positive Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Gene Expression Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Phosphorylation Protein Localization To Chromatin Negative Regulation Of Gene Expression Positive Regulation Of Cytokine Production Positive Regulation Of Peptidyl-threonine Phosphorylation Termination Of RNA Polymerase III Transcription Transcription Elongation From RNA Polymerase III Promoter Positive Regulation Of Chromosome Segregation Regulation Of Phosphorus Metabolic Process Cellular Response To Stress Positive Regulation Of Gene Expression Intermediate Filament Organization Nucleotide-excision Repair, DNA Damage Removal Lens Fiber Cell Development Positive Regulation Of Metabolic Process Response To Stress Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Astrocyte Development Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Modification-dependent Protein Catabolic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Tagcloud ?		actin actually associates bona centrosomal cooperation cytoskeletal delay depended e3 facilitates faithful fide hela ligases mitosis mitotic phosphorylatable phosphorylates plk1 polo repeat segregation tara telomeric thr trf1 trio
Tagcloud (Difference) ?		actin actually associates bona centrosomal cooperation cytoskeletal delay depended e3 facilitates faithful fide hela ligases mitosis mitotic phosphorylatable phosphorylates plk1 polo repeat segregation tara telomeric thr trf1 trio
Tagcloud (Intersection) ?