ARFGAP3 and CXCL8

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ARFGAP3	CXCL8
Description		ARF GTPase activating protein 3	C-X-C motif chemokine ligand 8
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Membrane	Extracellular Region Extracellular Space
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Cytokine Activity Interleukin-8 Receptor Binding Protein Binding Chemokine Activity Heparin Binding CXCR Chemokine Receptor Binding
	Biological Process	Intracellular Protein Transport Protein Secretion Protein Transport Vesicle-mediated Transport COPI Coating Of Golgi Vesicle	Angiogenesis Response To Molecule Of Bacterial Origin Chemotaxis Defense Response Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-mediated Signaling Regulation Of Cell Adhesion Neutrophil Chemotaxis Receptor Internalization Killing Of Cells Of Another Organism Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction Neutrophil Activation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Angiogenesis Embryonic Digestive Tract Development Induction Of Positive Chemotaxis Negative Regulation Of Cell Adhesion Molecule Production Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Neutrophil Chemotaxis Regulation Of Entry Of Bacterium Into Host Cell
Pathways		COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic CDC42 GTPase cycle RHOG GTPase cycle	Senescence-Associated Secretory Phenotype (SASP) Peptide ligand-binding receptors Chemokine receptors bind chemokines ATF4 activates genes in response to endoplasmic reticulum stress G alpha (i) signalling events Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling
Drugs			ABT-510 MDX-018 Rivanicline Oleandrin
Diseases
GWAS		Resting metabolic rate ( 28476931)	Chronic kidney disease ( 30226566) Coronary artery disease ( 30402224) Hypertension ( 30226566) Ischemic stroke ( 29930801) Myocardial infarction ( 30226566)
Interacting Genes		10 interacting genes: APP CD14 CFTR CXCL8 LIME1 RTN4IP1 SMAD2 SNCA SYPL1 ZDHHC17	23 interacting genes: ACKR1 ARFGAP3 BAG6 CCL2 CCL4 CCL5 CCL8 CTSL CXCR1 CXCR2 EP300 ERBB2 GNAI2 IL12A MMP14 MMP9 PF4 POMGNT1 SDC1 SGTA WASF1 ZFP36 ZNF598
Entrez ID		26286	3576
HPRD ID		06444	00909
Ensembl ID		ENSG00000242247	ENSG00000169429
Uniprot IDs		Q9NP61	C9J4T6 P10145
PDB IDs		2CRW	1ICW 1IKL 1IKM 1IL8 1ILP 1ILQ 1QE6 1ROD 2IL8 3IL8 4XDX 5D14 5WDZ 6LFM 6LFO 6N2U 6WZM 6XMN 8IC0 8XWN 8XX6
Enriched GO Terms of Interacting Partners?		Response To Interleukin-1 Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion Transmembrane Transport Regulation Of Presynapse Organization Regulation Of Monoatomic Ion Transport Regulation Of Long-term Neuronal Synaptic Plasticity Response To Growth Factor Positive Regulation Of Endocytosis Regulation Of Presynapse Assembly Regulation Of Monoatomic Ion Transmembrane Transport Endocytosis Myeloid Leukocyte Activation Regulation Of Neurotransmitter Uptake Regulation Of Cell Communication Cellular Response To Copper Ion Regulation Of Signaling Response To Lipid Golgi-associated Vesicle Membrane Amyloid Fibril Formation Microglial Cell Activation Receptor-mediated Endocytosis Cellular Response To Fibroblast Growth Factor Stimulus Cytoplasmic Vesicle Membrane Response To Copper Ion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Vesicle-mediated Transport Leukocyte Activation Involved In Inflammatory Response Regulation Of Calcium Ion Transport Response To Fibroblast Growth Factor Import Into Cell Tau Protein Binding Amyloid-beta Complex Regulation Of Neuronal Synaptic Plasticity Growth Cone Lamellipodium Regulation Of Synapse Organization Regulation Of Response To Calcium Ion Regulation Of Signal Transduction Macrophage Activation Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To Growth Factor Stimulus Cellular Response To CAMP Regulation Of Monoatomic Cation Transmembrane Transport Opsonin Receptor Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Response To Desipramine	Chemokine-mediated Signaling Pathway Granulocyte Chemotaxis Granulocyte Migration Cell Surface Receptor Signaling Pathway Myeloid Leukocyte Migration Leukocyte Chemotaxis Cytokine-mediated Signaling Pathway Cell Migration Chemokine Activity Cell Chemotaxis Locomotion Eosinophil Chemotaxis Leukocyte Migration Eosinophil Migration C-C Chemokine Binding Cell Motility Positive Regulation Of Leukocyte Migration CCR Chemokine Receptor Binding Signal Transduction Chemotaxis Positive Regulation Of Mononuclear Cell Migration Inflammatory Response Mononuclear Cell Migration Cytokine Activity G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Migration Regulation Of Leukocyte Migration Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Response To Stress Immune System Process Regulation Of Mononuclear Cell Migration Dendritic Cell Chemotaxis Interleukin-8-mediated Signaling Pathway Interleukin-8 Receptor Activity Regulation Of Immune System Process Antimicrobial Humoral Response Receptor-mediated Endocytosis Host-mediated Perturbation Of Viral Process Positive Regulation Of Immune System Process Monocyte Chemotaxis Defense Response Dendritic Cell Migration Regulation Of Lymphocyte Chemotaxis Interleukin-8 Binding Positive Regulation Of Macrophage Migration Regulation Of Apoptotic Process Positive Regulation Of Leukocyte Chemotaxis Host-mediated Perturbation Of Viral Transcription
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