ARFGAP3 and RTN4IP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ARFGAP3	RTN4IP1
Description		ARF GTPase activating protein 3	reticulon 4 interacting protein 1
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Membrane	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Matrix Membrane
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Nucleotide Binding Protein Binding Zinc Ion Binding NADPH Dehydrogenase (quinone) Activity Oxidoreductase Activity
	Biological Process	Intracellular Protein Transport Protein Secretion Protein Transport Vesicle-mediated Transport COPI Coating Of Golgi Vesicle	Ubiquinone Biosynthetic Process Nervous System Development Regulation Of Dendrite Development
Pathways		COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic CDC42 GTPase cycle RHOG GTPase cycle
Drugs
Diseases
GWAS		Resting metabolic rate ( 28476931)	Daytime sleep phenotypes ( 27126917) Metabolite levels ( 23823483)
Interacting Genes		10 interacting genes: APP CD14 CFTR CXCL8 LIME1 RTN4IP1 SMAD2 SNCA SYPL1 ZDHHC17	23 interacting genes: ARFGAP3 CALCOCO2 CBFA2T3 CENPK CTAG1A CTAG1B ERMN EXOC7 GGA2 HDX MARCHF5 PPP1R8 PYM1 RELA RTN4 RTN4R RUNX1T1 SCAF1 SMURF2 SORBS1 WBP11 WWTR1 ZYX
Entrez ID		26286	84816
HPRD ID		06444	18008
Ensembl ID		ENSG00000242247	ENSG00000130347
Uniprot IDs		Q9NP61	Q8WWV3
PDB IDs		2CRW	2VN8
Enriched GO Terms of Interacting Partners?		Response To Interleukin-1 Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion Transmembrane Transport Regulation Of Presynapse Organization Regulation Of Monoatomic Ion Transport Regulation Of Long-term Neuronal Synaptic Plasticity Response To Growth Factor Positive Regulation Of Endocytosis Regulation Of Presynapse Assembly Regulation Of Monoatomic Ion Transmembrane Transport Endocytosis Myeloid Leukocyte Activation Regulation Of Neurotransmitter Uptake Regulation Of Cell Communication Cellular Response To Copper Ion Regulation Of Signaling Response To Lipid Golgi-associated Vesicle Membrane Amyloid Fibril Formation Microglial Cell Activation Receptor-mediated Endocytosis Cellular Response To Fibroblast Growth Factor Stimulus Cytoplasmic Vesicle Membrane Response To Copper Ion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Vesicle-mediated Transport Leukocyte Activation Involved In Inflammatory Response Regulation Of Calcium Ion Transport Response To Fibroblast Growth Factor Import Into Cell Tau Protein Binding Amyloid-beta Complex Regulation Of Neuronal Synaptic Plasticity Growth Cone Lamellipodium Regulation Of Synapse Organization Regulation Of Response To Calcium Ion Regulation Of Signal Transduction Macrophage Activation Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To Growth Factor Stimulus Cellular Response To CAMP Regulation Of Monoatomic Cation Transmembrane Transport Opsonin Receptor Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Response To Desipramine	RNA Metabolic Process
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