MOB1B and WASHC3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		MOB1B	WASHC3
Description		MOB kinase activator 1B	WASH complex subunit 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome	Endosome Early Endosome Early Endosome Membrane WASH Complex
	Molecular Function	Protein Binding Kinase Activator Activity Kinase Binding Protein Kinase Activator Activity Protein Serine/threonine Kinase Activator Activity Metal Ion Binding	Protein Binding
	Biological Process	Regulation Of Protein Autophosphorylation Hippo Signaling	Exocytosis Protein Transport Endosomal Transport Actin Filament Polymerization Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		Signaling by Hippo
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Leukocyte telomere length ( 32109421) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Type 2 diabetes ( 30718926 32499647)	Appendicular lean mass ( 33097823)
Interacting Genes		4 interacting genes: APP NT5C2 TNIP1 WASHC3	55 interacting genes: ABI2 BFSP2 BLOC1S2 BLOC1S6 C20orf202 CCDC197 CCHCR1 CENPK CEP55 CKAP4 COG6 DTNBP1 GDF9 GNG13 GOLGA2 HAUS1 HSBP1 HSPB1 IFT20 IKBIP KDM1A KNSTRN KRT27 KRT6A KRT71 KRT75 LAMC1 LHX4 LMNB2 LUC7L2 MCRS1 MOB1A MOB1B MYOZ1 NDC80 NUP62 OPTN PAX6 PBXIP1 PCM1 PHOSPHO2 PTN RABEP1 SCARA5 SDCBP SNAP25 SNAPIN SRGAP2B SYCE1 TEX35 TFIP11 TXLNA TXLNB VPS52 WASHC1
Entrez ID		92597	51019
HPRD ID		17582	13031
Ensembl ID		ENSG00000173542	ENSG00000120860
Uniprot IDs		B3KSH6 Q7L9L4	F5GWI9 F5GZ97 Q9Y3C0
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Blood Circulation Regulation Of Defense Response Negative Regulation Of MiRNA Transcription Positive Regulation Of Inflammatory Response Regulation Of Amyloid-beta Clearance Astrocyte Activation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Microglial Cell Activation Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Membrane Protein Ectodomain Proteolysis Leukocyte Activation Involved In Inflammatory Response Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Nitric Oxide Metabolic Process Negative Regulation Of Viral Genome Replication Regulation Of Amyloid Precursor Protein Catabolic Process Cellular Response To Amyloid-beta Positive Regulation Of Calcium-mediated Signaling Leukocyte Cell-cell Adhesion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Macrophage Activation Response To Amyloid-beta Positive Regulation Of Interleukin-1 Beta Production Regulation Of Inflammatory Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Interleukin-1 Production Positive Regulation Of Chemokine Production Positive Regulation Of Neuron Apoptotic Process Regulation Of Innate Immune Response Defense Response Positive Regulation Of Type II Interferon Production Response To External Biotic Stimulus Positive Regulation Of Defense Response Negative Regulation Of Viral Process Regulation Of MiRNA Transcription Regulation Of Viral Genome Replication Antiviral Innate Immune Response Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of MiRNA Metabolic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Response To Gram-negative Bacterium Negative Regulation Of Branching Involved In Lung Morphogenesis	Organelle Organization BLOC-1 Complex Cytoskeleton Organization Establishment Of Organelle Localization Organelle Localization Axon Cytoplasm Cytoskeleton Axonal Transport Transport Along Microtubule Microtubule-based Process Axo-dendritic Transport Cytoskeleton-dependent Intracellular Transport Anterograde Synaptic Vesicle Transport Anterograde Axonal Transport Microtubule-based Transport Syntaxin Binding Cellular Localization Supramolecular Fiber Organization Establishment Of Localization In Cell Intermediate Filament Organization Synaptic Vesicle Transport Melanosome Organization Pigment Granule Organization Establishment Of Protein Localization Organelle Transport Along Microtubule Intermediate Filament Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Vesicle Transport Along Microtubule Intracellular Transport Centrosome Cycle Establishment Of Vesicle Localization Intracellular Protein Localization Protein Transport Vesicle Cytoskeletal Trafficking Microtubule-based Movement Structural Constituent Of Skin Epidermis Vesicle Localization Organelle Assembly Neuron Projection Development Spindle Pole Microtubule Organizing Center Organization Centriole Keratin Filament Mitotic Sister Chromatid Segregation Membraneless Organelle Assembly Localization Within Membrane Regulation Of Lysosome Size BORC Complex Sister Chromatid Segregation
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