MOB1B

Description		MOB kinase activator 1B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Kinase Activator Activity Kinase Binding Protein Kinase Activator Activity Protein Serine/threonine Kinase Activator Activity Metal Ion Binding
	Biological Process	Regulation Of Protein Autophosphorylation Hippo Signaling
Pathways		Signaling by Hippo
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Leukocyte telomere length ( 32109421) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Type 2 diabetes ( 30718926 32499647)
Novel Interacting Genes		1 novel interacting genes: TNF
Interacting Genes		4 interacting genes: APP NT5C2 TNIP1 WASHC3
Entrez ID		92597
HPRD ID		17582
Ensembl ID		ENSG00000173542
Uniprot IDs		B3KSH6 Q7L9L4
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Blood Circulation Regulation Of Defense Response Negative Regulation Of MiRNA Transcription Positive Regulation Of Inflammatory Response Regulation Of Amyloid-beta Clearance Astrocyte Activation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Microglial Cell Activation Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Membrane Protein Ectodomain Proteolysis Leukocyte Activation Involved In Inflammatory Response Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Nitric Oxide Metabolic Process Negative Regulation Of Viral Genome Replication Regulation Of Amyloid Precursor Protein Catabolic Process Cellular Response To Amyloid-beta Positive Regulation Of Calcium-mediated Signaling Leukocyte Cell-cell Adhesion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Macrophage Activation Response To Amyloid-beta Positive Regulation Of Interleukin-1 Beta Production Regulation Of Inflammatory Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Interleukin-1 Production Positive Regulation Of Chemokine Production Positive Regulation Of Neuron Apoptotic Process Regulation Of Innate Immune Response Defense Response Positive Regulation Of Type II Interferon Production Response To External Biotic Stimulus Positive Regulation Of Defense Response Negative Regulation Of Viral Process Regulation Of MiRNA Transcription Regulation Of Viral Genome Replication Antiviral Innate Immune Response Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of MiRNA Metabolic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Response To Gram-negative Bacterium Negative Regulation Of Branching Involved In Lung Morphogenesis
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