AIMP1 and IQGAP1

Number of citations of the paper that reports this interaction (PMID 9368021)
41

Data Source:
BioGRID (biochemical)
HPRD (in vitro)

		AIMP1	IQGAP1
Gene Name		aminoacyl tRNA synthetase complex-interacting multifunctional protein 1	IQ motif containing GTPase activating protein 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Cell Surface Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex Transport Vesicle	Nucleoplasm Cytoplasm Microtubule Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Microtubule Cytoskeleton Lateral Plasma Membrane Cell Junction Axon Growth Cone Midbody Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cell Leading Edge Slit Diaphragm Cytoplasmic Ribonucleoprotein Granule Neuron Projection Extracellular Vesicular Exosome
	Molecular Function	TRNA Binding Methionine-tRNA Ligase Activity Cytokine Activity Protein Binding Protein Homodimerization Activity	GTPase Inhibitor Activity GTPase Activator Activity Ras GTPase Activator Activity Calcium Ion Binding Protein Binding Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Kinase Binding Protein Phosphatase Binding Protein Complex Binding Protein Serine/threonine Kinase Activator Activity Rac GTPase Binding
	Biological Process	Angiogenesis Negative Regulation Of Endothelial Cell Proliferation Glucose Metabolic Process TRNA Aminoacylation For Protein Translation Methionyl-tRNA Aminoacylation Apoptotic Process Chemotaxis Inflammatory Response Cell Adhesion Signal Transduction Cell-cell Signaling Response To Wounding Gene Expression Leukocyte Migration	Regulation Of Cytokine Production Energy Reserve Metabolic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Ras GTPase Activity Negative Regulation Of Dephosphorylation Cellular Response To Platelet-derived Growth Factor Stimulus Negative Regulation Of Catalytic Activity Positive Regulation Of GTPase Activity Small Molecule Metabolic Process Positive Regulation Of Protein Kinase Activity Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Insulin Secretion Cellular Response To Calcium Ion Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Glomerular Visceral Epithelial Cell Development Neuron Projection Extension
Pathways		Cytosolic tRNA aminoacylation tRNA Aminoacylation	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism Regulation of insulin secretion Nephrin interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: AIMP2 APP ATP5A1 IQGAP1 MAPK14 MAPK8 RARS TSNAX	24 interactors: ACTA1 AIMP1 AKAP5 APC CALM1 CDC42 CDH1 CLIC5 CLIP1 CTNNB1 CYBB EZR GRIA4 KDR MAPK1 MEN1 NPHS1 PDLIM7 PRKACA RAC1 S100B STAU1 TSG101 YWHAQ
Entrez ID		9255	8826
HPRD ID		04676	04541
Ensembl ID		ENSG00000164022	ENSG00000140575
Uniprot IDs		B4DNK3 Q12904	P46940
PDB IDs		1E7Z 1EUJ 1FL0	1X0H 2RR8 3FAY 3I6X
Enriched GO Terms of Interacting Partners?		Small Molecule Metabolic Process Developmental Growth Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Apoptotic Process Toll-like Receptor 2 Signaling Pathway Regulation Of Cellular Protein Metabolic Process Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Programmed Cell Death MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cell Death Death MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway P38MAPK Cascade Response To Radiation Developmental Cell Growth Positive Regulation Of Protein Metabolic Process Growth TRNA Aminoacylation For Protein Translation Toll-like Receptor Signaling Pathway TRNA Aminoacylation Stress-activated MAPK Cascade Synaptic Growth At Neuromuscular Junction Peptidyl-serine Phosphorylation Stress-activated Protein Kinase Signaling Cascade Cellular Response To Growth Factor Stimulus Response To Growth Factor Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Cellular Response To Inorganic Substance Positive Regulation Of Catalytic Activity Collateral Sprouting In Absence Of Injury Nucleobase-containing Compound Metabolic Process Activation Of Innate Immune Response Developmental Growth Involved In Morphogenesis Regulation Of Protein Binding Cell Growth Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Cellular Response To Lipopolysaccharide Cellular Metabolic Process Multicellular Organismal Development Cellular Response To Molecule Of Bacterial Origin	Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cellular Component Organization Epithelium Development Cell Development Regulation Of Organelle Organization Positive Regulation Of Cellular Component Biogenesis Anatomical Structure Morphogenesis Multicellular Organismal Development Epithelial Cell Development System Development Epithelial Cell Differentiation Tissue Development Cell Differentiation Developmental Process Positive Regulation Of Signal Transduction Organ Development Anatomical Structure Development Cell Morphogenesis Involved In Differentiation Regulation Of Cellular Localization Cell-cell Junction Organization Nervous System Development Regulation Of Cell Proliferation Positive Regulation Of Organelle Organization Regulation Of Cell Differentiation Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Regulation Of Osteoblast Differentiation Epidermis Development Apoptotic Process Epidermal Cell Differentiation Organelle Organization Immune System Process Regulation Of Epithelial Cell Proliferation Programmed Cell Death Regulation Of Cytoskeleton Organization Cell Death Death Cell Morphogenesis Response To External Stimulus Regulation Of Signal Transduction Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Complex Assembly Positive Regulation Of Cellular Protein Metabolic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Regulation Of Protein Complex Assembly Neuron Differentiation Protein Localization
Tagcloud ?		basalis cycle cytokine diestrus dynamic element endometrium epithelium ere estrogen estrous estrus functionalis give glandular layers localized luminal might multifunctional ovarectomized regulator remodel remodeling stromal transcripts us uterine uterus	activating binds canonical clinicopathological coexpression correlating cytoplamic cytoplasm dishevelled dvl embryos expressions growths gtpase localization lymph membranous metastase metastases modulator nodal nsclc nucleus poor prognosis resection wnt xenopus
Tagcloud (Difference) ?		basalis cycle cytokine diestrus dynamic element endometrium epithelium ere estrogen estrous estrus functionalis give glandular layers localized luminal might multifunctional ovarectomized regulator remodel remodeling stromal transcripts us uterine uterus	activating binds canonical clinicopathological coexpression correlating cytoplamic cytoplasm dishevelled dvl embryos expressions growths gtpase localization lymph membranous metastase metastases modulator nodal nsclc nucleus poor prognosis resection wnt xenopus
Tagcloud (Intersection) ?