AIMP1 and TSNAX

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		AIMP1	TSNAX
Description		aminoacyl tRNA synthetase complex interacting multifunctional protein 1	translin associated factor X
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Cell Surface Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Perinuclear Region Of Cytoplasm Endoribonuclease Complex
	Molecular Function	TRNA Binding RNA Binding Cytokine Activity Protein Binding Protein Homodimerization Activity GTPase Binding	DNA Binding Single-stranded DNA Binding RNA Binding RNA Endonuclease Activity Protein Binding A2A Adenosine Receptor Binding Sequence-specific DNA Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Angiogenesis Negative Regulation Of Endothelial Cell Proliferation Translation Apoptotic Process Inflammatory Response Signal Transduction Cell-cell Signaling Blood Vessel Morphogenesis Leukocyte Migration Defense Response To Virus Positive Regulation Of Glucagon Secretion	Spermatogenesis Cell Differentiation SiRNA Processing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing
Pathways		Selenoamino acid metabolism Cytosolic tRNA aminoacylation Transcriptional and post-translational regulation of MITF-M expression and activity	Small interfering RNA (siRNA) biogenesis
Drugs
Diseases		Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD)
GWAS			Chronic periodontitis (mean interproximal clinical attachment level) ( 27601451) Metabolite levels ( 23823483)
Interacting Genes		51 interacting genes: AIMP2 APP ATP5F1A HOMER1 IQGAP1 LINC01232 MAPK14 MAPK8 MIR106B MIR107 MIR122 MIR128-1 MIR128-2 MIR138-2 MIR140 MIR15A MIR15B MIR17 MIR199A1 MIR199A2 MIR19B1 MIR19B2 MIR205 MIR206 MIR20B MIR214 MIR222 MIR25 MIR29C MIR31 MIR34A MIR34B MIR34C MIR451A MIR7-1 MIR7-2 MIR7-3 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7I OPTN RARS1 SUMO2 TSNAX	41 interacting genes: AIMP1 AKAP9 BEX3 BLOC1S5 C1D CARD9 CDK5RAP2 CEBPA CEP68 CKAP4 COG6 EMILIN1 GADD45G GOLGA3 GPATCH2 GRIPAP1 HMGB2 KCNE4 KRT31 LDB2 LDOC1 LZTS2 MECOM MRFAP1L1 MTCL2 NSMCE2 NTAQ1 PBXIP1 PRPF18 RALYL RFC5 SPRED2 SUN1 SYCE2 SYT17 TCF12 TCP11L1 TSN TSNAXIP1 UBE2I VPS28
Entrez ID		9255	7257
HPRD ID		04676	04270
Ensembl ID		ENSG00000164022	ENSG00000116918
Uniprot IDs		B4DNK3 Q12904	Q99598
PDB IDs		1E7Z 1EUJ 1FL0 4R3Z 8J9S 8ONG	3PJA 3QB5
Enriched GO Terms of Interacting Partners?		Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Extracellular Vesicle Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Vascular Endothelial Growth Factor Production MRNA Destabilization Regulation Of Gene Expression RNA Destabilization Negative Regulation Of Cytokine Production Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of MRNA Catabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Metabolic Process Positive Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Positive Regulation Of Connective Tissue Replacement Regulation Of Angiogenesis Regulation Of RNA Stability Regulation Of Vasculature Development Regulation Of Cytokine Production Negative Regulation Of Angiogenesis Regulation Of Connective Tissue Replacement Negative Regulation Of Vasculature Development Negative Regulation Of Translation Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Endothelial Cell Migration Negative Regulation Of Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Motility Regulation Of Cell Migration Involved In Sprouting Angiogenesis Extracellular Space Negative Regulation Of Locomotion Positive Regulation Of Tissue Remodeling Regulation Of MRNA Metabolic Process Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
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