MDFIC and SOCS4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		MDFIC	SOCS4
Description		MyoD family inhibitor domain containing	suppressor of cytokine signaling 4
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GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleolus Cytoplasm
	Molecular Function	Protein Binding Cyclin Binding Tat Protein Binding DNA-binding Transcription Factor Binding	Protein Binding
	Biological Process	Regulation Of Gene Expression Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Regulation Of JNK Cascade Positive Regulation Of Viral Transcription	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction
Pathways			RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Body mass index ( 26426971 28892062) Clozapine-induced cytotoxicity ( 25656473) Drug experimentation measurement ( 30718321) General risk tolerance (MTAG) ( 30643258) Hip circumference ( 28552196) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Number of sexual partners ( 30643258) Obesity ( 23818313) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia, bipolar disorder or recurrent major depressive disorder ( 34099189) Smoking status (ever vs never smokers) ( 30643258) Tonsillectomy ( 27182965 28928442)	Low density lipoprotein cholesterol levels ( 33339817) Total cholesterol levels ( 33339817)
Interacting Genes		4 interacting genes: CCNT1 CDK9 RPS6KA5 SOCS4	11 interacting genes: CNMD EGFR LDHAL6B MDFIC NR4A1 PALS1 PLPP6 SPRY1 TEKT4 TNK2 VWF
Entrez ID		29969	122809
HPRD ID		17103	18084
Ensembl ID		ENSG00000135272	ENSG00000180008
Uniprot IDs		Q9P1T7	Q8WXH5
PDB IDs		8YFC 8YFG 8ZU3	2IZV
Enriched GO Terms of Interacting Partners?		P-TEFb Complex 7SK SnRNA Binding Cyclin/CDK Positive Transcription Elongation Factor Complex SnRNA Binding Host-mediated Activation Of Viral Transcription Host-mediated Perturbation Of Viral Transcription Host-mediated Activation Of Viral Process Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription, Elongation Host-mediated Perturbation Of Viral Process Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Host-mediated Perturbation Of Symbiont Process Histone H2AS1 Kinase Activity Modulation Of Process Of Another Organism Histone H3S28 Kinase Activity Positive Regulation Of Protein Localization To Chromatin Histone H3S10 Kinase Activity Regulation Of Protein Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Transcription Pausing By RNA Polymerase II Transcription Cis-regulatory Region Binding Regulation Of Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Protein Localization To Chromatin Positive Regulation Of Metabolic Process Transcription Elongation-coupled Chromatin Remodeling Transcription By RNA Polymerase II Regulation Of Protein Localization To Chromatin Transcription Elongation Factor Activity Positive Regulation Of CREB Transcription Factor Activity Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Regulation Of MRNA 3'-end Processing Protein Phosphorylation Protein Serine Kinase Activity Regulation Of Protein Phosphorylation Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Phosphorylation Negative Regulation Of Protein Tyrosine Kinase Activity Protein Modification Process Protein Serine/threonine Kinase Activity Negative Regulation Of Signaling Receptor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cytokine-mediated Signaling Pathway DNA-templated Transcription Regulation Of Phosphorylation Protein Kinase Binding Positive Regulation Of RNA Metabolic Process
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