MDFIC and CCNT1

Number of citations of the paper that reports this interaction (PMID 12944466)
15

Data Source:
BioGRID (pull down)

		MDFIC	CCNT1
Gene Name		MyoD family inhibitor domain containing	cyclin T1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus	Nucleus Nucleoplasm Nucleolus Positive Transcription Elongation Factor Complex B
	Molecular Function	Protein Binding Transcription Factor Binding Cyclin Binding Tat Protein Binding	DNA Binding Chromatin Binding Protein Binding SnRNA Binding Protein Kinase Binding Transcription Regulatory Region DNA Binding
	Biological Process	Transcription, DNA-templated Activation Of JUN Kinase Activity Viral Process Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Transcription	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Protein Phosphorylation Cell Cycle Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Viral Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription Cell Division
Pathways			Loss of Function of TGFBR2 in Cancer Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription HIV Infection SMAD2/3 MH2 Domain Mutants in Cancer Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery TGFBR1 LBD Mutants in Cancer RNA Polymerase II Pre-transcription Events SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer HIV elongation arrest and recovery HIV Life Cycle Generic Transcription Pathway HIV Transcription Elongation TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Host Interactions of HIV factors Loss of Function of SMAD4 in Cancer Interactions of Tat with host cellular proteins TGFBR1 KD Mutants in Cancer Pausing and recovery of Tat-mediated HIV elongation Loss of Function of TGFBR1 in Cancer Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription of the HIV genome SMAD4 MH2 Domain Mutants in Cancer RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Obesity ( 23818313)
Protein-Protein Interactions		4 interactors: CCNT1 CDK9 RPS6KA5 SOCS4	26 interactors: AFF4 AHR BRD4 CDK9 CTD ESR1 GRIPAP1 GRN GTF2F1 HEXIM1 HEXIM2 HIC2 HTATSF1 HTN1 KAT2B MBP MDFIC MYC NCOA2 NUFIP1 PML POLR2A PURA RN7SK SKP2 SUPT5H
Entrez ID		29969	904
HPRD ID		17103	03938
Ensembl ID		ENSG00000135272	ENSG00000129315
Uniprot IDs		Q9P1T7	A8K4M5 A9XU13 O60563
PDB IDs			2PK2 3BLH 3BLQ 3BLR 3LQ5 3MI9 3MIA 3MY1 3TN8 3TNH 3TNI 4BCF 4BCG 4BCH 4BCI 4BCJ 4EC8 4EC9 4IMY
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Viral Transcription Transcription Elongation From RNA Polymerase II Promoter Cellular Response To Organic Substance Regulation Of Cellular Protein Metabolic Process Regulation Of Viral Transcription Positive Regulation Of Viral Process Cellular Response To Growth Factor Stimulus Cellular Response To Cytokine Stimulus Response To Growth Factor DNA-templated Transcription, Elongation Regulation Of Protein Metabolic Process Response To Cytokine Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Histone H2A-S1 Phosphorylation Replication Fork Arrest Regulation Of Histone Modification Enzyme Linked Receptor Protein Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Viral Process Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Surface Receptor Signaling Pathway Cellular Protein Modification Process Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Protein Phosphorylation Response To Transforming Growth Factor Beta Regulation Of Chromosome Organization Positive Regulation Of Metabolic Process DNA-templated Transcription, Initiation Histone H3-S10 Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Phosphorylation Protein Phosphorylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Histone Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Cellular Protein Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Histone H3-S28 Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Phosphorylation Regulation Of Nitrogen Compound Metabolic Process Cytokine-mediated Signaling Pathway Signal Transduction Regulation Of Cellular Ketone Metabolic Process	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Positive Regulation Of Viral Transcription Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Viral Process Cellular Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Viral Transcription Regulation Of Viral Process Positive Regulation Of Viral Process Positive Regulation Of Cellular Biosynthetic Process Nitrogen Compound Metabolic Process Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-templated Transcription, Initiation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of Cell Cycle Transcription Elongation From RNA Polymerase II Promoter Chromatin Remodeling DNA-templated Transcription, Elongation Regulation Of Metabolic Process Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity 7-methylguanosine MRNA Capping Positive Regulation Of Metabolic Process
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