SCGB3A1 and XRCC3

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		SCGB3A1	XRCC3
Description		secretoglobin family 3A member 1	X-ray repair cross complementing 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Cytoplasm Mitochondrion Cytosol Rad51C-XRCC3 Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Cytokine Activity Protein Binding	Nucleotide Binding Four-way Junction DNA Binding DNA Binding Protein Binding ATP Binding Crossover Junction DNA Endonuclease Activity ATP-dependent DNA Damage Sensor Activity
	Biological Process	Signal Transduction Negative Regulation Of Cell Growth Regulation Of Cell Population Proliferation Positive Regulation Of Myoblast Fusion	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Regulation Of Centrosome Duplication Interstrand Cross-link Repair Double-strand Break Repair Via Synthesis-dependent Strand Annealing Resolution Of Mitotic Recombination Intermediates Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint T-circle Formation Telomeric Loop Disassembly Telomere Maintenance Via Telomere Trimming
Pathways			HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 26426971 29273807) Schizophrenia ( 25056061 29483656)
Interacting Genes		10 interacting genes: AURKA BAG4 FBXW7 FGFR4 MARCO NOTCH3 RHBDD2 TGFB1 TSG101 XRCC3	22 interacting genes: BAP1 BCAS3 CXCL1 FANCG GREB1 ITIH5 LRATD2 MRC2 OSGIN1 PALB2 PSMC3IP RAD51 RAD51C RAD51D RNF20 SCGB3A1 SERPINB5 SNAI1 SWSAP1 TFF1 ZNHIT3 ZSWIM7
Entrez ID		92304	7517
HPRD ID		05932	07201
Ensembl ID		ENSG00000161055	ENSG00000126215
Uniprot IDs		Q96QR1	O43542 Q53XC8
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Intracellular Signal Transduction Regulation Of ERK1 And ERK2 Cascade Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Fibroblast Migration Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Extracellular Matrix Disassembly Positive Regulation Of MAPK Cascade Lipid Homeostasis Regulation Of Signaling Regulation Of Cell Cycle Phase Transition Proteasomal Protein Catabolic Process Liver Regeneration Positive Regulation Of Cell Communication Positive Regulation Of Signaling Macromolecule Catabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Regulation Of Establishment Of Protein Localization Positive Regulation Of ERBB Signaling Pathway Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Proteolysis Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Fibroblast Migration Protein Catabolic Process Regulation Of Organelle Organization Proteolysis Regulation Of Protein Targeting To Mitochondrion Regulation Of MAPK Cascade Positive Regulation Of Cell Cycle Process Positive Regulation Of MiRNA Transcription Regulation Of Cell Cycle Process Regulation Of Centrosome Cycle Animal Organ Regeneration Branch Elongation Involved In Mammary Gland Duct Branching Positive Regulation Of Microglia Differentiation Vasculature Development Cellular Response To Acetaldehyde Negative Regulation Of MRNA Modification Positive Regulation Of MiRNA Metabolic Process Regulation Of Extracellular Matrix Organization Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Cell Cycle	Recombinational Repair DNA Strand Invasion Double-strand Break Repair Via Homologous Recombination DNA Recombination Reciprocal Meiotic Recombination Homologous Recombination Double-strand Break Repair Telomere Maintenance Via Recombination ATP-dependent DNA Damage Sensor Activity Shu Complex Mitotic Recombination DNA Metabolic Process DNA Repair Rad51B-Rad51C-Rad51D-XRCC2 Complex DNA Recombinase Assembly Interstrand Cross-link Repair DNA Damage Response Meiosis I Cell Cycle Process Four-way Junction DNA Binding Telomere Maintenance Single-stranded DNA Binding Nucleic Acid Metabolic Process Telomere Organization Replication Fork ATP-dependent Activity, Acting On DNA Reproductive Process Growth Factor Activity Response To Glucoside Chromosome Organization Meiosis I Female Meiosis Sister Chromatid Cohesion Nucleate Erythrocyte Differentiation Thrombocyte Differentiation Meiotic Joint Molecule Formation DNA Recombinase Auxiliary Factor Complex Recombinase Activator Activity Meiotic Strand Invasion Involved In Reciprocal Meiotic Recombination Histone H2B C-terminal K Residue Ubiquitin Ligase Activity Condensed Nuclear Chromosome Mitotic Recombination-dependent Replication Fork Processing DNA Strand Exchange Activity Chromosome Organization Involved In Meiotic Cell Cycle Presynaptic Intermediate Filament Cytoskeleton Rad51C-XRCC3 Complex Meiotic DNA Recombinase Assembly Mesoderm Development Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Macrophage Homeostasis Cellular Response To Stress Nucleobase-containing Compound Metabolic Process
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