DLGAP1 and SHANK2

Number of citations of the paper that reports this interaction (PMID 10527873)
22

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vitro)

		DLGAP1	SHANK2
Gene Name		discs, large (Drosophila) homolog-associated protein 1	SH3 and multiple ankyrin repeat domains 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Cell Junction Postsynaptic Membrane Neuronal Postsynaptic Density	Photoreceptor Outer Segment Photoreceptor Inner Segment Cellular_component Neurofilament Plasma Membrane Ionotropic Glutamate Receptor Complex Postsynaptic Density Apical Plasma Membrane Cell Junction Growth Cone Brush Border Membrane Neuron Projection Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Ciliary Membrane
	Molecular Function	Protein Binding	Protein Binding SH3 Domain Binding GKAP/Homer Scaffold Activity Ionotropic Glutamate Receptor Binding
	Biological Process	Synaptic Transmission	Synapse Assembly Learning Memory Adult Behavior Social Behavior Exploration Behavior Long-term Synaptic Potentiation Long Term Synaptic Depression Vocalization Behavior
Pathways
Drugs
Diseases
GWAS		Cardiac Troponin-T levels ( 23247143) Eating disorders ( 22911880) Economic and political preferences (time) ( 22566634) Obesity-related traits ( 23251661)	Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075)
Protein-Protein Interactions		21 interactors: APC DLG1 DLG2 DLG3 DLG4 DLGAP2 DLGAP3 DYNLL1 DYNLL2 GRB2 GRIN2A GRIN2C ITSN1 ITSN2 KCNA4 MYO5A SHANK1 SHANK2 SHANK3 SORBS2 TANC1	15 interactors: ARHGEF7 BAI2 BAIAP2 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNM2 LPHN1 LPHN2 SHARPIN SLC9A3 SSTR2
Entrez ID		9229	22941
HPRD ID		09260	04479
Ensembl ID		ENSG00000170579	ENSG00000162105
Uniprot IDs		A8MXQ8 B7Z2J5 O14490	C0SPH0 Q9UPX8
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell-cell Signaling Synaptic Transmission Protein Localization To Synapse Receptor Localization To Synapse Nervous System Development Vocalization Behavior Receptor Clustering Learning Dendritic Spine Organization Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Cell Morphogenesis Involved In Neuron Differentiation Locomotion Social Behavior Neuron Projection Morphogenesis Membrane Depolarization Neuron Development Signaling Cell Communication Learning Or Memory Cell Morphogenesis Involved In Differentiation Regulation Of Membrane Potential Dendritic Spine Morphogenesis Cognition Nucleotide Phosphorylation Neuron Differentiation Regulation Of Signaling Cell Projection Organization Neuron Projection Development Neurological System Process Cell Projection Morphogenesis Synapse Organization Cell Part Morphogenesis Dendritic Spine Development Neurogenesis Behavior Protein Localization To Membrane Anatomical Structure Development System Development Regulation Of Ion Transmembrane Transport Anatomical Structure Morphogenesis Cell Morphogenesis Establishment Or Maintenance Of Apical/basal Cell Polarity Single-organism Behavior Generation Of Neurons Regulation Of Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential Developmental Process Memory Multicellular Organismal Development	Cell-cell Signaling Signaling Cell Communication Synaptic Transmission Nervous System Development Neuron Projection Morphogenesis Dendritic Spine Organization Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Cell Morphogenesis Focal Adhesion Assembly Neuron Development Cell Morphogenesis Adherens Junction Assembly Lamellipodium Organization Neuron Differentiation Cell-substrate Junction Assembly Cell Projection Organization Endocytosis Regulation Of Cellular Component Organization Regulation Of Axon Extension Negative Regulation Of Membrane Tubulation Post-Golgi Vesicle-mediated Transport Adherens Junction Organization System Development Regulation Of CD40 Signaling Pathway Protein Linear Polyubiquitination Positive Regulation Of Lamellipodium Morphogenesis Generation Of Neurons Synaptic Vesicle Transport Neurogenesis Somatostatin Signaling Pathway Regulation Of Cell Size Regulation Of Cell Projection Organization Dendrite Development Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Cell Development Multicellular Organismal Development Axonogenesis Maintenance Of Apical/basal Cell Polarity Regulation Of Lamellipodium Morphogenesis Regulation Of Axonogenesis Regulation Of Synaptic Plasticity Cellular Component Assembly G-protein Coupled Receptor Signaling Pathway Anatomical Structure Development Receptor Localization To Synapse Dendritic Spine Maintenance
Tagcloud ?		18p11 aided blindness cataracts centimorgans chorioretinal clul1 compiled elastin emilin2 interfacer intronic lipin lpin2 microfibril mrcl3 mrlc2 myom1 myomesin myopia myosin myp2 pedigree positional prioritizing segregated tgifbeta underway zfp161	acetylation address carbamylated cepo display e1a epigenetic epo erythropoietin gap43 implications interest issue markedly modifications neurites neuronal neurons neuropsychiatric p300 possibly potentiates psd95 regulate spine subsequent transactivation upregulation yet
Tagcloud (Difference) ?		18p11 aided blindness cataracts centimorgans chorioretinal clul1 compiled elastin emilin2 interfacer intronic lipin lpin2 microfibril mrcl3 mrlc2 myom1 myomesin myopia myosin myp2 pedigree positional prioritizing segregated tgifbeta underway zfp161	acetylation address carbamylated cepo display e1a epigenetic epo erythropoietin gap43 implications interest issue markedly modifications neurites neuronal neurons neuropsychiatric p300 possibly potentiates psd95 regulate spine subsequent transactivation upregulation yet
Tagcloud (Intersection) ?