DLGAP1 and GRIN2C

Number of citations of the paper that reports this interaction (PMID 9694864)
45

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		DLGAP1	GRIN2C
Gene Name		discs, large (Drosophila) homolog-associated protein 1	glutamate receptor, ionotropic, N-methyl D-aspartate 2C
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Cell Junction Postsynaptic Membrane Neuronal Postsynaptic Density	Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Postsynaptic Membrane
	Molecular Function	Protein Binding	N-methyl-D-aspartate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Cation Channel Activity Protein Binding PDZ Domain Binding Protein N-terminus Binding
	Biological Process	Synaptic Transmission	Transport Glutamate Receptor Signaling Pathway Synaptic Transmission Protein Localization Response To Wounding Directional Locomotion Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Negative Regulation Of Protein Catabolic Process Neuromuscular Process Controlling Balance Regulation Of Excitatory Postsynaptic Membrane Potential Cation Transmembrane Transport
Pathways			Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs			L-Glutamic Acid Glycine Meperidine Tenocyclidine
Diseases
GWAS		Cardiac Troponin-T levels ( 23247143) Eating disorders ( 22911880) Economic and political preferences (time) ( 22566634) Obesity-related traits ( 23251661)
Protein-Protein Interactions		21 interactors: APC DLG1 DLG2 DLG3 DLG4 DLGAP2 DLGAP3 DYNLL1 DYNLL2 GRB2 GRIN2A GRIN2C ITSN1 ITSN2 KCNA4 MYO5A SHANK1 SHANK2 SHANK3 SORBS2 TANC1	6 interactors: DLG3 DLG4 DLGAP1 ERBB2IP IL16 INADL
Entrez ID		9229	2905
HPRD ID		09260	00699
Ensembl ID		ENSG00000170579	ENSG00000161509
Uniprot IDs		A8MXQ8 B7Z2J5 O14490	H0Y2V8 O15398 Q14957 Q8IW23
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell-cell Signaling Synaptic Transmission Protein Localization To Synapse Receptor Localization To Synapse Nervous System Development Vocalization Behavior Receptor Clustering Learning Dendritic Spine Organization Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Cell Morphogenesis Involved In Neuron Differentiation Locomotion Social Behavior Neuron Projection Morphogenesis Membrane Depolarization Neuron Development Signaling Cell Communication Learning Or Memory Cell Morphogenesis Involved In Differentiation Regulation Of Membrane Potential Dendritic Spine Morphogenesis Cognition Nucleotide Phosphorylation Neuron Differentiation Regulation Of Signaling Cell Projection Organization Neuron Projection Development Neurological System Process Cell Projection Morphogenesis Synapse Organization Cell Part Morphogenesis Dendritic Spine Development Neurogenesis Behavior Protein Localization To Membrane Anatomical Structure Development System Development Regulation Of Ion Transmembrane Transport Anatomical Structure Morphogenesis Cell Morphogenesis Establishment Or Maintenance Of Apical/basal Cell Polarity Single-organism Behavior Generation Of Neurons Regulation Of Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential Developmental Process Memory Multicellular Organismal Development	Establishment Or Maintenance Of Apical/basal Cell Polarity Receptor Localization To Synapse Protein Localization To Synapse Establishment Or Maintenance Of Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Clustering Nucleotide Phosphorylation Synaptic Transmission Chemotaxis Basal Protein Localization Regulation Of Behavior Cell-cell Signaling Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Maintenance Of Apical/basal Cell Polarity Negative Regulation Of Receptor Internalization Locomotory Exploration Behavior Locomotion Dendritic Spine Morphogenesis Maintenance Of Cell Polarity Synaptic Vesicle Maturation Cellular Protein Localization Protein Localization To Membrane Vocalization Behavior Signaling Axon Guidance Cell Communication Induction Of Positive Chemotaxis Dendritic Spine Development Movement Of Cell Or Subcellular Component Establishment Of Planar Polarity Negative Regulation Of Receptor-mediated Endocytosis Dendritic Spine Organization Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Morphogenesis Of A Polarized Epithelium Cortical Actin Cytoskeleton Organization Asymmetric Protein Localization Exploration Behavior Postsynaptic Membrane Organization Axonogenesis Cortical Cytoskeleton Organization Response To External Stimulus Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Receptor Internalization Cellular Response To Stimulus Positive Regulation Of Positive Chemotaxis Nucleotide Metabolic Process Axon Development Positive Regulation Of Excitatory Postsynaptic Membrane Potential Cell Morphogenesis Involved In Neuron Differentiation
Tagcloud ?		18p11 aided blindness cataracts centimorgans chorioretinal clul1 compiled elastin emilin2 interfacer intronic lipin lpin2 microfibril mrcl3 mrlc2 myom1 myomesin myopia myosin myp2 pedigree positional prioritizing segregated tgifbeta underway zfp161	6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta
Tagcloud (Difference) ?		18p11 aided blindness cataracts centimorgans chorioretinal clul1 compiled elastin emilin2 interfacer intronic lipin lpin2 microfibril mrcl3 mrlc2 myom1 myomesin myopia myosin myp2 pedigree positional prioritizing segregated tgifbeta underway zfp161	6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta
Tagcloud (Intersection) ?