MTA2 and BCL11B

Number of citations of the paper that reports this interaction (PMID 16091750)
36

Data Source:
BioGRID (pull down)

		MTA2	BCL11B
Gene Name		metastasis associated 1 family, member 2	B-cell CLL/lymphoma 11B (zinc finger protein)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nuclear Chromatin Nucleoplasm Transcription Factor Complex Membrane NuRD Complex Protein Complex	Nucleus
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Transcription Factor Binding RNA Polymerase II Repressing Transcription Factor Binding Sequence-specific DNA Binding Transcription Factor Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding Nucleosomal DNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation Chromatin Organization Chromatin Assembly Or Disassembly Histone Deacetylation ATP-dependent Chromatin Remodeling Positive Regulation Of Transcription From RNA Polymerase II Promoter	Keratinocyte Development Epithelial Cell Morphogenesis Transcription, DNA-templated Negative Regulation Of Cell Proliferation Regulation Of Keratinocyte Proliferation Regulation Of Lipid Metabolic Process Striatal Medium Spiny Neuron Differentiation Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Post-embryonic Camera-type Eye Development T Cell Differentiation In Thymus T Cell Receptor V(D)J Recombination Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Positive T Cell Selection Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Alpha-beta T Cell Differentiation Thymus Development Olfactory Bulb Axon Guidance
Pathways		Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance
Drugs
Diseases
GWAS			Aortic stiffness ( 22068335) Corneal curvature ( 22969067)
Protein-Protein Interactions		21 interactors: APPL1 APPL2 BCL11B ESR1 FKBP3 HDAC2 HIST3H3 HNRNPD MBD3 MBD3L2 MED30 NACC2 RBBP4 RBBP7 SATB1 SATB2 SPEN TP53 TSC22D3 UBE3C YY1	9 interactors: CBX5 MBD3 MTA2 NR2F1 NR2F2 RBBP4 RBBP7 SP1 SUV39H1
Entrez ID		9219	64919
HPRD ID		07233	05950
Ensembl ID		ENSG00000149480	ENSG00000127152
Uniprot IDs		O94776	L8B567 L8B7P7 L8B862 L8B8F6 Q9C0K0
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Chromosome Organization Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Chromatin Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Metabolic Process Chromatin Modification Regulation Of Nitrogen Compound Metabolic Process Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter ATP-dependent Chromatin Remodeling Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Organelle Organization Positive Regulation Of Macromolecule Biosynthetic Process Cell Proliferation Positive Regulation Of Cellular Biosynthetic Process Regulation Of Gene Expression, Epigenetic Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Rhythmic Process Regulation Of Apoptotic Process Forebrain Neuron Fate Commitment Cellular Metabolic Process Regulation Of Cell Death DNA Metabolic Process Negative Regulation Of Cell Proliferation Chromatin Assembly	Negative Regulation Of Gene Expression Regulation Of Gene Expression, Epigenetic ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromatin Remodeling Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Chromatin Modification Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated Chromatin Organization RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Chromosome Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Chromatin Assembly Or Disassembly RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Gene Expression CENP-A Containing Nucleosome Assembly Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Chromatin Silencing Histone Exchange DNA Replication-independent Nucleosome Assembly Centromere Complex Assembly Histone Modification Biosynthetic Process Sequestering Of Nodal From Receptor Via Nodal Binding Radial Pattern Formation Pattern Specification Process Gene Silencing Steroid Hormone Mediated Signaling Pathway In Utero Embryonic Development Negative Regulation Of Nodal Signaling Pathway Cellular Heat Acclimation Regulation Of Transcription Involved In Lymphatic Endothelial Cell Fate Commitment
Tagcloud ?		ag ag1478 blocking combat combinatorial dosage egfr exerts fasn greatly hsp90 ideal iialpha iressa isotope labeling lc mechanistically oncogenes phosphatidylinositol pi3k pi4kiialpha prdx2 presents proteomic silac strengthened ultimately xenograft	cadherin discovered dnm2 druggable exhibitedthe fat1 fbxw7 frequencies guide harboured herc1 jak jak3 lymphoblastic mll2 mutational notch1 notch2 phf6 recurrent regulators reln secretase splicing subclonal unfavourable warranted wt1 zrsr2
Tagcloud (Difference) ?		ag ag1478 blocking combat combinatorial dosage egfr exerts fasn greatly hsp90 ideal iialpha iressa isotope labeling lc mechanistically oncogenes phosphatidylinositol pi3k pi4kiialpha prdx2 presents proteomic silac strengthened ultimately xenograft	cadherin discovered dnm2 druggable exhibitedthe fat1 fbxw7 frequencies guide harboured herc1 jak jak3 lymphoblastic mll2 mutational notch1 notch2 phf6 recurrent regulators reln secretase splicing subclonal unfavourable warranted wt1 zrsr2
Tagcloud (Intersection) ?