BCL11B and CBX5

Number of citations of the paper that reports this interaction (PubMedID 12692243)
40

Data Source:
HPRD (in vitro, in vivo)

		BCL11B	CBX5
Description		BCL11 transcription factor B	chromobox 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus SWI/SNF Complex Neuron Projection	Histone Deacetylase Complex Chromosome, Centromeric Region Kinetochore Chromosome, Telomeric Region Heterochromatin Nucleus Nuclear Envelope Nucleoplasm Chromosome Pericentric Heterochromatin Nucleolus Chromocenter PML Body Transcription Repressor Complex Protein-containing Complex Histone Methyltransferase Complex Site Of DNA Damage Ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Chromatin Binding Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Histone Deacetylase Binding Ribonucleoprotein Complex Binding Protein-containing Complex Binding Histone H3K9me2/3 Reader Activity DNA-binding Transcription Factor Binding Histone Reader Activity
	Biological Process	Keratinocyte Development Epithelial Cell Morphogenesis Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Apoptotic Process Axonogenesis Negative Regulation Of Cell Population Proliferation Post-embryonic Development Regulation Of Gene Expression Regulation Of Keratinocyte Proliferation Regulation Of Lipid Metabolic Process Striatal Medium Spiny Neuron Differentiation Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Central Nervous System Neuron Differentiation Post-embryonic Camera-type Eye Development T Cell Differentiation In Thymus T Cell Receptor V(D)J Recombination Hematopoietic Stem Cell Migration Odontogenesis Of Dentin-containing Tooth Positive T Cell Selection Skin Development Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Alpha-beta T Cell Differentiation Thymus Development T Cell Apoptotic Process Negative Regulation Of T Cell Apoptotic Process Thymocyte Apoptotic Process Negative Regulation Of Thymocyte Apoptotic Process Olfactory Bulb Axon Guidance Lymphoid Lineage Cell Migration Into Thymus	Negative Regulation Of Transcription By RNA Polymerase II DNA Damage Response Heterochromatin Formation Negative Regulation Of DNA-templated Transcription
Pathways		Formation of the embryonic stem cell BAF (esBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	SUMOylation of chromatin organization proteins Transcriptional Regulation by E2F6 Factors involved in megakaryocyte development and platelet production Regulation of endogenous retroelements by KRAB-ZFP proteins
Drugs			Copper
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Airway wall thickness ( 25517131) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Aortic stiffness ( 22068335) Bipolar disorder ( 34002096 31043756) Brain morphology (MOSTest) ( 32665545) Corneal curvature ( 22969067) Diastolic blood pressure night-to-day ratio in hypertension ( 29973135) Hematocrit ( 32888494) Hemoglobin ( 32888494) Medial thalamic nuclei volume ( 34006833) Metabolite levels ( 23823483) Posterior thalamic nuclei volume ( 34006833) Proximal colorectal cancer ( 33632709) Red blood cell count ( 32888494) Schizophrenia ( 30285260 29483656 28991256 25056061) Staphylococcus aureus infection ( 24847357) Systolic blood pressure night-to-day ratio in hypertension ( 29973135) Triglyceride levels in HIV infection ( 33109212) Waist circumference ( 34074324)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Alcohol consumption ( 31358974) Hip circumference ( 28552196) Mean platelet volume ( 22139419) Meat-related diet ( 32066663) Platelet count ( 32888494) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		5 interacting genes: CBX5 NR2F1 NR2F2 SP1 SUV39H1	61 interacting genes: ARHGDIA ARL5A BAP1 BARD1 BCL11B BRCA1 CBX1 CBX3 CHAF1A DNMT3B DSN1 ELOA2 ELOC ENO1 FSHR GOLGA8EP H1-4 H1-5 H2AC25 H2BC26 H3-4 H3C1 H3C15 H4C16 HDAC4 HDAC5 HDAC9 HECW2 INCENP ISG15 LAP3 LBR LRIF1 MBD1 MCC MIS12 MKI67 NIPBL NR2F1 NSD3 NSL1 PRR14 RPSA SMARCA4 SP1 SP100 SRPK1 STAM2 SUB1 SUV39H1 TAF4 TRIM24 TRIM28 UBC UBE2A UBE2B VPS28 XRCC6 XRN1 ZNF280C ZNF280D
Entrez ID		64919	23468
HPRD ID		05950	05131
Ensembl ID		ENSG00000127152	ENSG00000094916
Uniprot IDs		L8B567 L8B7P7 L8B862 L8B8F6 Q9C0K0	P45973 V9HWG0
PDB IDs			3FDT 3I3C 8UXQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Transcription Repressor Complex Cellular Response To Wortmannin Heterochromatin Nuclear Receptor Activity Radial Pattern Formation Evoked Excitatory Postsynaptic Potential Negative Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Response To Wortmannin Histone Deacetylase Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Cellular Response To Zinc Ion Starvation Regulation Of Endothelial Cell Proliferation Histone H3K9 Trimethyltransferase Activity Chromosome, Centromeric Region Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Gene Expression, Epigenetic Heterochromatin Formation ENoSc Complex RDNA Heterochromatin Negative Regulation Of RNA Biosynthetic Process Lymphatic Endothelial Cell Fate Commitment Cellular Response To Starvation Negative Regulation Of Nucleobase-containing Compound Metabolic Process RDNA Heterochromatin Formation Retinoic Acid-responsive Element Binding Regulation Of Endothelial Cell Migration Histone H3K9me2 Methyltransferase Activity Regulation Of Transcription By Glucose Response To Starvation Histone H3K9 Methyltransferase Activity Intracellular Receptor Signaling Pathway Maternal Placenta Development Regulation Of DNA-templated Transcription Transcription Cis-regulatory Region Binding Rhythmic Process Regulation Of RNA Biosynthetic Process Cellular Response To Nutrient Levels Nuclear Lamina Facultative Heterochromatin Formation Epigenetic Regulation Of Gene Expression Epigenetic Programming In The Zygotic Pronuclei Chromatin Silencing Complex DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Lymph Vessel Development Trophoblast Giant Cell Differentiation Interneuron Migration	Chromatin Organization Chromatin Remodeling Chromosome Nucleus Negative Regulation Of Gene Expression, Epigenetic Nucleoplasm Epigenetic Regulation Of Gene Expression Heterochromatin Formation Chromo Shadow Domain Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Heterochromatin DNA Binding Structural Constituent Of Chromatin Nucleosome Organization Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleosome Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Protein-DNA Complex Assembly Chromosome Segregation Regulation Of Macromolecule Biosynthetic Process Euchromatin Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Nucleosome Assembly Chromatin MIS12/MIND Type Complex Chromosome Organization Histone Deacetylase Binding Regulation Of Transcription By RNA Polymerase II Chromatin Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA Metabolic Process Negative Regulation Of Gene Expression Chromosome, Centromeric Region Chromosome, Telomeric Region DNA Damage Response Histone Deacetylase Activity, Hydrolytic Mechanism Transcription Corepressor Activity Histone H2AK127 Ubiquitin Ligase Activity
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