MTA2 and MBD3L2

Number of citations of the paper that reports this interaction (PMID 15701600)
9

Data Source:
BioGRID (pull down)

		MTA2	MBD3L2
Gene Name		metastasis associated 1 family, member 2	methyl-CpG binding domain protein 3-like 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nuclear Chromatin Nucleoplasm Transcription Factor Complex Membrane NuRD Complex Protein Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Transcription Factor Binding RNA Polymerase II Repressing Transcription Factor Binding Sequence-specific DNA Binding Transcription Factor Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding Nucleosomal DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation Chromatin Organization Chromatin Assembly Or Disassembly Histone Deacetylation ATP-dependent Chromatin Remodeling Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance
Drugs
Diseases
GWAS
Protein-Protein Interactions		21 interactors: APPL1 APPL2 BCL11B ESR1 FKBP3 HDAC2 HIST3H3 HNRNPD MBD3 MBD3L2 MED30 NACC2 RBBP4 RBBP7 SATB1 SATB2 SPEN TP53 TSC22D3 UBE3C YY1	10 interactors: CHD4 HDAC1 HDAC2 MBD2 MBD3 MTA1 MTA2 POLD3 RBBP4 RBBP7
Entrez ID		9219	125997
HPRD ID		07233	12139
Ensembl ID		ENSG00000149480	ENSG00000230522
Uniprot IDs		O94776	Q8NHZ7
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Chromosome Organization Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Chromatin Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Metabolic Process Chromatin Modification Regulation Of Nitrogen Compound Metabolic Process Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter ATP-dependent Chromatin Remodeling Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Organelle Organization Positive Regulation Of Macromolecule Biosynthetic Process Cell Proliferation Positive Regulation Of Cellular Biosynthetic Process Regulation Of Gene Expression, Epigenetic Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Rhythmic Process Regulation Of Apoptotic Process Forebrain Neuron Fate Commitment Cellular Metabolic Process Regulation Of Cell Death DNA Metabolic Process Negative Regulation Of Cell Proliferation Chromatin Assembly	ATP-dependent Chromatin Remodeling Chromatin Remodeling Regulation Of Gene Expression, Epigenetic Chromosome Organization Negative Regulation Of Gene Expression, Epigenetic Chromatin Organization Chromatin Modification Organelle Organization Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process RNA Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Histone Deacetylation Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Deacetylation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Circadian Regulation Of Gene Expression Fungiform Papilla Formation Negative Regulation Of Cellular Metabolic Process RNA Metabolic Process Biosynthetic Process Regulation Of Gene Expression Fungiform Papilla Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Receptor Biosynthetic Process Gene Expression Fungiform Papilla Development Eyelid Development In Camera-type Eye Hair Follicle Placode Formation Histone Modification Tongue Morphogenesis Regulation Of Receptor Biosynthetic Process Histone H4 Deacetylation Chromatin Assembly Or Disassembly DNA Metabolic Process Circadian Rhythm
Tagcloud ?		ag ag1478 blocking combat combinatorial dosage egfr exerts fasn greatly hsp90 ideal iialpha iressa isotope labeling lc mechanistically oncogenes phosphatidylinositol pi3k pi4kiialpha prdx2 presents proteomic silac strengthened ultimately xenograft
Tagcloud (Difference) ?		ag ag1478 blocking combat combinatorial dosage egfr exerts fasn greatly hsp90 ideal iialpha iressa isotope labeling lc mechanistically oncogenes phosphatidylinositol pi3k pi4kiialpha prdx2 presents proteomic silac strengthened ultimately xenograft
Tagcloud (Intersection) ?