BCL11B and NR2F2

Number of citations of the paper that reports this interaction (PubMedID 10744719)
58

Data Source:
HPRD (two hybrid, in vitro)

		BCL11B	NR2F2
Description		BCL11 transcription factor B	nuclear receptor subfamily 2 group F member 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus SWI/SNF Complex Neuron Projection	Nucleus Nucleoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Retinoic Acid Binding DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Keratinocyte Development Epithelial Cell Morphogenesis Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Apoptotic Process Axonogenesis Negative Regulation Of Cell Population Proliferation Post-embryonic Development Regulation Of Gene Expression Regulation Of Keratinocyte Proliferation Regulation Of Lipid Metabolic Process Striatal Medium Spiny Neuron Differentiation Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Central Nervous System Neuron Differentiation Post-embryonic Camera-type Eye Development T Cell Differentiation In Thymus T Cell Receptor V(D)J Recombination Hematopoietic Stem Cell Migration Odontogenesis Of Dentin-containing Tooth Positive T Cell Selection Skin Development Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Alpha-beta T Cell Differentiation Thymus Development T Cell Apoptotic Process Negative Regulation Of T Cell Apoptotic Process Thymocyte Apoptotic Process Negative Regulation Of Thymocyte Apoptotic Process Olfactory Bulb Axon Guidance Lymphoid Lineage Cell Migration Into Thymus	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Neuron Migration Maternal Placenta Development Negative Regulation Of Endothelial Cell Proliferation Lymph Vessel Development Positive Regulation Of Systemic Arterial Blood Pressure Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Skeletal Muscle Tissue Development Female Gonad Development Fertilization Anterior/posterior Pattern Specification Radial Pattern Formation Negative Regulation Of Endothelial Cell Migration Cell Differentiation Intracellular Receptor Signaling Pathway Forebrain Development Response To Estradiol Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Blood Vessel Morphogenesis Placenta Blood Vessel Development Trophoblast Giant Cell Differentiation Lymphatic Endothelial Cell Fate Commitment Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Interneuron Migration
Pathways		Formation of the embryonic stem cell BAF (esBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Airway wall thickness ( 25517131) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Aortic stiffness ( 22068335) Bipolar disorder ( 34002096 31043756) Brain morphology (MOSTest) ( 32665545) Corneal curvature ( 22969067) Diastolic blood pressure night-to-day ratio in hypertension ( 29973135) Hematocrit ( 32888494) Hemoglobin ( 32888494) Medial thalamic nuclei volume ( 34006833) Metabolite levels ( 23823483) Posterior thalamic nuclei volume ( 34006833) Proximal colorectal cancer ( 33632709) Red blood cell count ( 32888494) Schizophrenia ( 30285260 29483656 28991256 25056061) Staphylococcus aureus infection ( 24847357) Systolic blood pressure night-to-day ratio in hypertension ( 29973135) Triglyceride levels in HIV infection ( 33109212) Waist circumference ( 34074324)	Adventurousness ( 30643258) Birth weight ( 31043758) Cannabis use ( 27023175) Cerebrospinal fluid p-tau levels in Alzheimer's disease dementia ( 29274321) Chronotype ( 30696823) Cognitive decline rate in late mild cognitive impairment ( 26252872) Immune response to measles-mumps-rubella vaccine ( 24811271) Lymphangioleiomyomatosis (sporadic) ( 31000673) Metabolite levels ( 23823483) Motion sickness ( 25628336) Optic disc area ( 25631615) Optic disc size ( 31809533) Photic sneeze reflex ( 27182965) PR interval ( 32439900) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Serum alkaline phosphatase levels ( 33547301) Sex hormone-binding globulin levels ( 22829776) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659)
Interacting Genes		5 interacting genes: CBX5 NR2F1 NR2F2 SP1 SUV39H1	21 interacting genes: BCL11A BCL11B BIK EP300 FOXP1 FOXP2 FOXP4 HDAC1 HIPK3 MYOD1 NCOR2 NR2F6 NR3C1 NSD1 PHB2 PIAS1 SETD7 SQSTM1 TENT5A TRIM24 TRIP4
Entrez ID		64919	7026
HPRD ID		05950	00139
Ensembl ID		ENSG00000127152	ENSG00000185551
Uniprot IDs		L8B567 L8B7P7 L8B862 L8B8F6 Q9C0K0	F1D8R0 P24468
PDB IDs			3CJW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Transcription Repressor Complex Cellular Response To Wortmannin Heterochromatin Nuclear Receptor Activity Radial Pattern Formation Evoked Excitatory Postsynaptic Potential Negative Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Response To Wortmannin Histone Deacetylase Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Cellular Response To Zinc Ion Starvation Regulation Of Endothelial Cell Proliferation Histone H3K9 Trimethyltransferase Activity Chromosome, Centromeric Region Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Gene Expression, Epigenetic Heterochromatin Formation ENoSc Complex RDNA Heterochromatin Negative Regulation Of RNA Biosynthetic Process Lymphatic Endothelial Cell Fate Commitment Cellular Response To Starvation Negative Regulation Of Nucleobase-containing Compound Metabolic Process RDNA Heterochromatin Formation Retinoic Acid-responsive Element Binding Regulation Of Endothelial Cell Migration Histone H3K9me2 Methyltransferase Activity Regulation Of Transcription By Glucose Response To Starvation Histone H3K9 Methyltransferase Activity Intracellular Receptor Signaling Pathway Maternal Placenta Development Regulation Of DNA-templated Transcription Transcription Cis-regulatory Region Binding Rhythmic Process Regulation Of RNA Biosynthetic Process Cellular Response To Nutrient Levels Nuclear Lamina Facultative Heterochromatin Formation Epigenetic Regulation Of Gene Expression Epigenetic Programming In The Zygotic Pronuclei Chromatin Silencing Complex DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Lymph Vessel Development Trophoblast Giant Cell Differentiation Interneuron Migration	Negative Regulation Of RNA Metabolic Process Nuclear Receptor Binding Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Chromatin Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process DNA Binding Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Sequence-specific DNA Binding Chromatin Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Zinc Ion Binding Nucleus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nucleoplasm Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Negative Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity P53 Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Androgen Receptor Binding Positive Regulation Of Metabolic Process Regulation Of Apoptotic Process Chromatin Organization Macromolecule Biosynthetic Process Negative Regulation Of Protein Oligomerization Regulation Of Programmed Cell Death
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