LRRFIP1 and MED4

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		LRRFIP1	MED4
Gene Name		leucine rich repeat (in FLII) interacting protein 1	mediator complex subunit 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane	Nucleus Nucleoplasm Membrane Mediator Complex
	Molecular Function	DNA Binding Double-stranded RNA Binding Protein Binding Protein Homodimerization Activity	RNA Polymerase II Transcription Cofactor Activity Transcription Cofactor Activity Receptor Activity Protein Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Biological_process Positive Regulation Of Type I Interferon Production Innate Immune Response Negative Regulation Of Transcription, DNA-templated	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Intracellular Steroid Hormone Receptor Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated
Pathways		Signaling by FGFR in disease Cytosolic sensors of pathogen-associated DNA LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Signaling by FGFR1 mutants Signaling by FGFR mutants Signaling by FGFR1 fusion mutants Innate Immune System	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS		Adiposity ( 22739583)
Protein-Protein Interactions		3 interactors: CEP44 FLII MED4	36 interactors: AES AMOT AP2M1 ATF7IP C1orf216 CCDC101 CCDC146 CCHCR1 CTDP1 CTNNBL1 FAM13C FOXJ3 FRMD6 FTCD HAUS1 IFT20 KIFC3 LRRFIP1 MAB21L3 MCRS1 MED13 MED25 MED30 MED9 NDC80 NDE1 PCBD2 PUM2 SDCBP SMARCD1 SMARCE1 SSX3 TNFAIP8 TXLNA USHBP1 WDTC1
Entrez ID		9208	29079
HPRD ID		04460	16145
Ensembl ID		ENSG00000124831	ENSG00000136146
Uniprot IDs		B4DPC0 Q32MZ4	Q9NPJ6
PDB IDs		4H22
Enriched GO Terms of Interacting Partners?			Organelle Organization Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Process Regulation Of Nitrogen Compound Metabolic Process Gene Expression Nucleosome Disassembly Cellular Protein Localization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Establishment Of Cell Polarity Cellular Localization Cellular Nitrogen Compound Metabolic Process Mitotic Nuclear Division Centrosome Localization Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Establishment Of Mitotic Spindle Orientation Androgen Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Mediator Complex Assembly Opsin Transport Regulation Of Cellular Process Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Nitrogen Compound Metabolic Process Chromosome Organization Establishment Or Maintenance Of Cell Polarity Chromatin Organization Cell Division Protein Localization Negative Regulation Of Transcription, DNA-templated Movement Of Cell Or Subcellular Component Spindle Localization Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Microtubule-based Process Pteridine-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cytoskeleton Organization Negative Regulation Of RNA Biosynthetic Process
Tagcloud ?		abat accuracy biomarkers bisulfite cloning dapp1 diagnosis differential downregulated draft fadd hematologic hypermethylated hypermethylation mds methylation microarray myelodysplastic noninvasive patterns plbd1 profiles refined screened sequencing smpd3 specificity validate validation
Tagcloud (Difference) ?		abat accuracy biomarkers bisulfite cloning dapp1 diagnosis differential downregulated draft fadd hematologic hypermethylated hypermethylation mds methylation microarray myelodysplastic noninvasive patterns plbd1 profiles refined screened sequencing smpd3 specificity validate validation
Tagcloud (Intersection) ?