LRRFIP1 and SH2D2A

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		LRRFIP1	SH2D2A
Description		LRR binding FLII interacting protein 1	SH2 domain containing 2A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane	Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Double-stranded RNA Binding Protein Binding Protein Homodimerization Activity Cadherin Binding	Protein Binding SH3 Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Angiogenesis Signal Transduction Cell Differentiation T Cell Proliferation
Pathways		Signaling by cytosolic FGFR1 fusion mutants LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Signaling by FGFR1 in disease	VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS		Adiposity ( 23505185) Apolipoprotein A1 levels ( 32203549) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Longevity ( 30294719)	Autoimmune thyroid disease ( 32581359) Platelet count ( 27863252 32888494) Plateletcrit ( 32888494) Sjögren's syndrome ( 28076899)
Interacting Genes		9 interacting genes: CEP44 FBXO7 FLII MED4 OLIG2 RNF10 SERPINB5 SH2D2A TSG101	34 interacting genes: APPL1 AR ARID5A CRK DAPK1 EGFR ERBB2 ERBB3 ERBB4 GAB1 ITK KDR KIT LCK LINC02875 LNX1 LRRFIP1 LRRK1 MAP3K2 MAPK7 MET MFHAS1 NAA16 PLCG1 PPP1R21 SOCS3 SPTB STAT3 SYK TSC1 TXK VCP ZHX3 ZSCAN1
Entrez ID		9208	9047
HPRD ID		04460	05152
Ensembl ID		ENSG00000124831	ENSG00000027869
Uniprot IDs		A0A0F7NGI8 B4DPC0 Q32MZ4	Q5UBZ2 Q5UBZ3 Q9NP31
PDB IDs		4H22
Enriched GO Terms of Interacting Partners?			Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Kinase Activity Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Signal Transduction ATP Binding Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Epithelial Cell Proliferation Nucleotide Binding Signal Transduction Regulation Of Intracellular Signal Transduction ERBB Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of MAPK Cascade Regulation Of Signaling Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of Programmed Cell Death Transferase Activity Cellular Response To Growth Factor Stimulus Cellular Developmental Process Negative Regulation Of Programmed Cell Death Receptor Complex Cell Differentiation ERBB2 Signaling Pathway Protein Autophosphorylation Response To Growth Factor Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Basal Plasma Membrane Protein Phosphorylation Regulation Of Epithelial Cell Proliferation Protein Phosphatase Binding Negative Regulation Of Defense Response SH2 Domain Binding Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Negative Regulation Of Inflammatory Response Growth Factor Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
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