SCAF11 and U2AF2

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, two hybrid)

		SCAF11	U2AF2
Description		SR-related CTD associated factor 11	U2 small nuclear RNA auxiliary factor 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Body	Commitment Complex Prp19 Complex Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck U2-type Prespliceosome U2AF Complex
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Nucleic Acid Binding RNA Binding Protein Binding Poly-pyrimidine Tract Binding Enzyme Binding Pre-mRNA 3'-splice Site Binding C2H2 Zinc Finger Domain Binding Molecular Function Inhibitor Activity
	Biological Process	Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Splicing	Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Negative Regulation Of Protein Ubiquitination Positive Regulation Of RNA Splicing Negative Regulation Of MRNA Splicing, Via Spliceosome
Pathways			Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Protein hydroxylation
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Fish- and plant-related diet ( 32066663) Hemoglobin levels ( 32327693) Morning person ( 30696823) Multiple sclerosis ( 31604244) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Refractive error ( 32231278)	HDL cholesterol levels ( 32203549) Menopause (age at onset) ( 26414677)
Interacting Genes		12 interacting genes: ATXN1L PSEN1 RNF10 SNRNP70 SRPK1 SRSF1 SRSF2 SRSF3 SRSF4 STAT3 SUMO2 U2AF2	71 interacting genes: - APBB1 ATXN1 BEND7 CCAR1 CDC42 CHIC2 CPSF7 DACH1 DDX6 DPPA2 DVL2 EPB41 FUBP1 GEMIN2 GLIS2 HLA-DMA HMBOX1 IL7R INO80B KHDC4 KHDRBS3 LURAP1 MAP1B MRPL15 NKAPD1 OGT OTUB2 PHF5A PIN1 POLR2A PRPF40A PUF60 QKI RBFOX2 RBM11 RBM39 RBM4 RBMY1F RBMY1J SAP30BP SCAF11 SF1 SF3B3 SF3B5 SF3B6 SMAD5 SNRPA SRPK1 SRPK2 SRSF1 SRSF11 SRSF3 STAC3 SUGP1 SUMO2 TCERG1 TCF23 THAP1 TLE5 TOP1 U2AF1 USP7 WT1 ZNF107 ZNF526 ZNF57 ZNF71 ZNF835 ZRSR2 ZRSR2P1
Entrez ID		9169	11338
HPRD ID		04720	01872
Ensembl ID		ENSG00000139218	ENSG00000063244
Uniprot IDs		F8VXG7 Q99590	P26368
PDB IDs			1JMT 1O0P 1OPI 1U2F 2G4B 2HZC 2M0G 2U2F 2YH0 2YH1 3VAF 3VAG 3VAH 3VAI 3VAJ 3VAK 3VAL 3VAM 4FXW 4TU7 4TU8 4TU9 5EV1 5EV2 5EV3 5EV4 5W0G 5W0H 6TR0 6XLV 6XLW 6XLX 7S3A 7S3B 7S3C 7SN6 8P25 9C7A 9C7B 9DWU
Enriched GO Terms of Interacting Partners?		Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process RNA Splicing MRNA Metabolic Process Nuclear Speck MRNA Processing RNA Binding Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Nucleus MRNA Binding RNA Processing Nucleic Acid Binding Regulation Of Macromolecule Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of RNA Splicing Postsynapse To Nucleus Signaling Pathway Regulation Of Metabolic Process Nucleoplasm Cellular Response To Interleukin-17 RNA Splicing, Via Transesterification Reactions Primary MiRNA Binding Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Response To Cytokine Sequence-specific MRNA Binding Response To Peptide Negative Regulation Of MRNA Metabolic Process U2-type Prespliceosome Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Catabolic Process Negative Regulation Of RNA Splicing Cellular Response To Cytokine Stimulus Negative Regulation Of Macromolecule Metabolic Process Spliceosomal Complex Positive Regulation Of ATP Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome Negative Regulation Of Metabolic Process	RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing RNA Binding RNA Metabolic Process Nucleic Acid Binding Nucleoplasm Regulation Of RNA Splicing Nucleic Acid Metabolic Process Nucleus Spliceosomal Complex Regulation Of MRNA Splicing, Via Spliceosome Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions Regulation Of MRNA Processing Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Nuclear Speck Regulation Of Nucleobase-containing Compound Metabolic Process Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Binding Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process U2AF Complex Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Binding Positive Regulation Of Biosynthetic Process RS Domain Binding Pre-mRNA 3'-splice Site Binding Protein-containing Complex Assembly U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex MRNA Splice Site Recognition Negative Regulation Of RNA Metabolic Process Protein-containing Complex Organization Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Splicing
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