SYT12 and DNAJC5

Number of citations: 64 (PubMedID 29997244)
Data Source: BioGRID (fluorescent resonance energy transfer)

		SYT12	DNAJC5
Name		synaptotagmin 12	DnaJ heat shock protein family (Hsp40) member C5
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Synapse Exocytic Vesicle Hippocampal Mossy Fiber To CA3 Synapse Presynapse	Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Plasma Membrane Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuromuscular Junction Azurophil Granule Membrane Specific Granule Membrane Melanosome Chromaffin Granule Membrane Intracellular Membrane-bounded Organelle Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Presynapse
	Molecular Function	SNARE Binding Calcium-dependent Phospholipid Binding Calcium Ion Sensor Activity	Protein Binding ATP-dependent Protein Binding
	Biological Process	Vesicle-mediated Transport Regulation Of Calcium Ion-dependent Exocytosis Spontaneous Exocytosis Of Neurotransmitter Long-term Synaptic Potentiation Presynaptic Modulation Of Chemical Synaptic Transmission	Protein Folding Exocytosis Synaptic Vesicle Exocytosis Negative Regulation Of Neuron Apoptotic Process Regulated Exocytosis Neuron Apoptotic Process Regulation Of Synaptic Vesicle Cycle
Pathways		Neurexins and neuroligins	Neutrophil degranulation GABA synthesis, release, reuptake and degradation Sensory processing of sound by inner hair cells of the cochlea
GWAS		Bipolar disorder ( 21926972 ) Waist circumference adjusted for body mass index ( 34021172 )	Immature fraction of reticulocytes ( 32888494 ) Mean platelet volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Prostate cancer ( 23535732 )
Interacting Genes		2 interacting genes: CFTR DNAJC5	49 interacting genes: AGFG1 AP2B1 ARHGEF15 BTC CADM1 CADPS CD2 CFTR CGB5 CLCN3 ERC1 FAS FCHO1 GRM8 HBA2 KHDC4 LIN7A LIN7C NECAP1 NRXN3 PPFIA4 PRKACA PRKCG PRRC2B PSMD12 RABGEF1 RBSN SCAMP3 SCAMP5 SH3GL3 SLC17A8 SLC18A2 SLC30A3 SLC32A1 SNAP29 SNAP91 SNCA STX12 STX3 STX4 STX6 SV2A SYT12 SYT5 SYT9 VAMP1 VAMP3 VAMP4 VAMP7
Entrez ID		91683	80331
HPRD ID		07337	08539
Ensembl ID		ENSG00000173227	ENSG00000101152
Uniprot IDs		B0AZL9 Q8IV01	Q9H3Z4
PDB IDs		Not available	2N04 2N05
GO Terms Enriched among Interactors		Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Lysosomal Membrane Positive Regulation Of Enamel Mineralization Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization ATP-dependent Protein Binding Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Chromaffin Granule Membrane Amelogenesis Regulation Of Vesicle-mediated Transport ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Cellular Response To Forskolin Regulation Of Synaptic Vesicle Cycle Response To Forskolin Chloride Transmembrane Transporter Activity Sperm Capacitation Bicarbonate Transport Water Transport Multicellular Organismal-level Water Homeostasis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Ion Transmembrane Transporter Activity Cholesterol Biosynthetic Process 14-3-3 Protein Binding Fluid Transport Transepithelial Transport Synaptic Vesicle Exocytosis Vesicle Docking Involved In Exocytosis Positive Regulation Of Transporter Activity ABC-type Transporter Activity Sterol Biosynthetic Process Chloride Channel Complex Positive Regulation Of Biomineral Tissue Development Azurophil Granule Membrane Cellular Response To CAMP Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Vesicle Docking Cholesterol Transport	Synaptic Vesicle Membrane Vesicle-mediated Transport Synapse SNARE Binding Neurotransmitter Transport SNARE Complex Secretion By Cell Exocytosis Cytoplasmic Vesicle Establishment Of Localization In Cell SNAP Receptor Activity Synaptic Vesicle Secretion Regulation Of Vesicle-mediated Transport Presynapse Protein Transport Regulation Of Exocytosis Plasma Membrane Membrane Establishment Of Protein Localization Organelle Fusion SNARE Complex Assembly Neuron Projection Vesicle Fusion Organelle Membrane Fusion Clathrin-coated Endocytic Vesicle Membrane Vesicle Organization Neurotransmitter Secretion Organelle Localization By Membrane Tethering Regulation Of Regulated Secretory Pathway Phagocytic Vesicle Glutamatergic Synapse Regulation Of Secretion By Cell Organelle Localization Membrane Docking Vesicle-mediated Transport In Synapse Membrane Fusion Regulation Of Secretion Recycling Endosome Membrane Endosome Signal Release Vesicle Docking Intracellular Protein Localization Regulation Of Transport Positive Regulation Of Exocytosis Membrane Organization Regulation Of Endocytosis Chemical Synaptic Transmission Trans-synaptic Signaling Long-term Synaptic Potentiation