COL23A1 and EXOSC8

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		COL23A1	EXOSC8
Gene Name		collagen, type XXIII, alpha 1	exosome component 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Collagen Trimer Endoplasmic Reticulum Lumen Plasma Membrane Integral Component Of Membrane	Exosome (RNase Complex) Nucleus Nucleolus Cytoplasm Cytosol
	Molecular Function		Exoribonuclease Activity Protein Binding AU-rich Element Binding
	Biological Process	Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing Biological_process Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Pathways		Collagen formation Collagen degradation Integrin cell surface interactions Collagen biosynthesis and modifying enzymes Degradation of the extracellular matrix	Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS		Bulimia nervosa ( 23568457) Obesity-related traits ( 23251661)
Protein-Protein Interactions		3 interactors: EXOSC8 FURIN LSM8	42 interactors: AEN ATF2 COL23A1 COX5A CRMP1 CWC22 DIS3 DUSP23 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC9 FAM90A1 FHOD1 FOXN3 FRG1 LSM1 LSM7 MKRN1 MORN4 MPP6 OTUD4 RASSF1 REL RPP14 SKIV2L2 SNRPC TCEA2 TFAP4 TXNDC17 TXNDC9 UBC UPF2 USP6 XRN1 XRN2 ZFP36
Entrez ID		91522	11340
HPRD ID		16733	09351
Ensembl ID		ENSG00000050767	ENSG00000120699
Uniprot IDs		Q86Y22	Q96B26
PDB IDs			2NN6
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Receptor Catabolic Process Nerve Growth Factor Processing Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Production Viral Protein Processing MRNA Metabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Peptidyl-glutamic Acid Carboxylation Signal Peptide Processing Virion Assembly Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Gene Expression Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Peptide Biosynthetic Process Peptide Hormone Processing Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Collagen Catabolic Process	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process MRNA Metabolic Process RRNA Metabolic Process RRNA Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Ribosome Biogenesis Aromatic Compound Catabolic Process Nuclear MRNA Surveillance Ribonucleoprotein Complex Biogenesis RNA Metabolic Process Cellular Macromolecule Catabolic Process NcRNA Metabolic Process RNA Surveillance RNA Phosphodiester Bond Hydrolysis RRNA Catabolic Process Nucleobase-containing Compound Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Maturation Of 5.8S RRNA Gene Expression Cellular Nitrogen Compound Metabolic Process Catabolic Process Nitrogen Compound Metabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process DNA Deamination Histone MRNA Catabolic Process RNA Processing Cellular Metabolic Process Histone MRNA Metabolic Process MRNA Processing Intracellular MRNA Localization Metabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' DNA Modification Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RNA Splicing SnoRNA Metabolic Process RNA Splicing, Via Transesterification Reactions
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?