COL23A1

Description		collagen type XXIII alpha 1 chain
Image		No pdb structure
GO Annotations	Cellular Component	Collagen Trimer Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Cell Surface Membrane Extracellular Matrix
	Molecular Function	Protein Binding Heparin Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Identical Protein Binding
	Biological Process
Pathways		Collagen degradation Collagen biosynthesis and modifying enzymes Integrin cell surface interactions Collagen chain trimerization
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Bulimia nervosa ( 23568457) Cannabis dependence symptom count ( 27028160) HDL levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Nose length ( 30174134) Obesity-related traits ( 23251661) Presence of antiphospholipid antibodies ( 27098658) Prostate cancer ( 29892016)
Novel Interacting Genes		1 novel interacting genes: PTGES2
Interacting Genes		4 interacting genes: CFTR EXOSC8 FURIN LSM8
Entrez ID		91522
HPRD ID		16733
Ensembl ID		ENSG00000050767
Uniprot IDs		Q86Y22
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Isomerase Activity Positive Regulation Of Monoatomic Anion Transport Negative Regulation Of Nerve Growth Factor Production Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Dibasic Protein Processing Zymogen Inhibition Nerve Growth Factor Production Negative Regulation Of Receptor Catabolic Process Negative Regulation Of Neurotrophin Production U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing 12-hydroxyheptadecatrienoic Acid Synthase Activity Prostaglandin-E Synthase Activity Positive Regulation Of Enamel Mineralization Viral Translation Viral Life Cycle Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Cytokine Precursor Processing Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta1 Production Nerve Growth Factor Binding Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Lsm2-8 Complex Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Heparan Sulfate Binding U4 SnRNA 3'-end Processing Amelogenesis Endosome Membrane ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Signal Peptide Processing RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) U6 SnRNP Glutathione Binding
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