DYRK1B and GSC2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DYRK1B	GSC2
Description		dual specificity tyrosine phosphorylation regulated kinase 1B	goosecoid homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus	Chromatin Nucleus
	Molecular Function	Nucleotide Binding Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA Repair Protein Phosphorylation DNA Damage Response Myoblast Fusion Positive Regulation Of DNA-templated Transcription Adipose Tissue Development	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anatomical Structure Morphogenesis
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Macular thickness ( 30535121)	Metabolite levels ( 22916037)
Interacting Genes		12 interacting genes: DCAF7 GSC2 HDAC5 ID2 MAP2K3 MAPK1 MAPK14 MBP PAK1 PCBD1 RANBP9 TROAP	60 interacting genes: ALPP ANXA5 ASPH BEST3 BNIP2 C19orf47 C1D CALM1 CALM2 CALM3 CALR CDKN2D CIAO2A COL8A1 CRCP CSNK2A1 DYRK1B EGLN3 EIF5A ETFDH FAM221B FKBP6 GALNT11 GCM2 GTF2H5 GTSF1L GUCA1A GUCY1A2 HMBOX1 ISX KDM6A KLHL38 KRT34 KRTAP5-9 LCE3E LTO1 MAD2L2 MAPK9 MARF1 MID2 MORF4L1 MRPL53 MRPS23 NME7 PACSIN2 PDE4C PRKAB2 PTER RNF4 SCAF1 SDCBP TIPIN TNPO2 TSR2 UBE2R2 VCX2 XRCC4 YPEL5 ZNF444 ZNF587
Entrez ID		9149	2928
HPRD ID		05188	03506
Ensembl ID		ENSG00000105204	ENSG00000063515
Uniprot IDs		A0A9H4CVU7 Q9Y463	O15499
PDB IDs		8C2Z
Enriched GO Terms of Interacting Partners?		MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Muscle Cell Differentiation Cellular Senescence NLRP1 Inflammasome Complex Assembly Negative Regulation Of Muscle Cell Differentiation Regulation Of Striated Muscle Cell Differentiation Cellular Response To UV-B MAP Kinase Activity MAP Kinase Kinase Activity Response To Lipopolysaccharide Mammary Gland Epithelial Cell Proliferation Response To Molecule Of Bacterial Origin Regulation Of Blood Vessel Endothelial Cell Migration Protein Serine Kinase Activity Response To UV-B Stress-activated MAPK Cascade Protein-containing Complex Negative Regulation Of Hippo Signaling P38MAPK Cascade Protein Serine/threonine Kinase Activity Intracellular Signaling Cassette Cellular Response To Vascular Endothelial Growth Factor Stimulus Response To Insulin Nucleoplasm Cellular Response To Lipopolysaccharide Astrocyte Differentiation Canonical Inflammasome Complex Assembly Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Erythrocyte Differentiation Cellular Response To Molecule Of Bacterial Origin Regulation Of Endothelial Cell Migration Cytosol Protein Kinase Activity Lipopolysaccharide-mediated Signaling Pathway Regulation Of Cell Migration Negative Regulation Of Striated Muscle Cell Differentiation Pyroptotic Inflammatory Response Regulation Of Cell Motility Regulation Of Hippo Signaling Regulation Of Myotube Differentiation Positive Regulation Of Cell Migration Regulation Of Locomotion Positive Regulation Of Cell Motility Regulation Of Erythrocyte Differentiation Positive Regulation Of Locomotion Positive Regulation Of Metabolic Process Kinase Activity Positive Regulation Of Metalloendopeptidase Activity Heart Development	Regulation Of Cell Communication By Electrical Coupling Detection Of Calcium Ion Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Calcium Channel Complex Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of High Voltage-gated Calcium Channel Activity Titin Binding Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity DNA Metabolic Process Response To Metal Ion Protein Phosphatase Activator Activity Calyx Of Held Protein Binding Catalytic Complex Negative Regulation Of Transporter Activity Response To Calcium Ion Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Calcineurin-mediated Signaling Presynaptic Cytosol Myelin Sheath Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cardiac Muscle Contraction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Positive Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Calcium Ion Transmembrane Transport Regulation Of Striated Muscle Contraction DNA Damage Response Spindle Microtubule Negative Regulation Of Monoatomic Ion Transport Nucleic Acid Metabolic Process Presynaptic Endocytosis Substantia Nigra Development Sarcoplasmic Reticulum Lumen Calcium Channel Regulator Activity Detection Of Chemical Stimulus Sperm Midpiece Adenylate Cyclase Binding Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Long-term Synaptic Potentiation Nucleobase-containing Compound Metabolic Process
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