DYRK1B and TROAP

Number of citations of the paper that reports this interaction (PubMedID 32707033)
104

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfer, affinity chromatography technology)

		DYRK1B	TROAP
Description		dual specificity tyrosine phosphorylation regulated kinase 1B	trophinin associated protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus	Cytoplasm
	Molecular Function	Nucleotide Binding Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Protein Binding
	Biological Process	DNA Repair Protein Phosphorylation DNA Damage Response Myoblast Fusion Positive Regulation Of DNA-templated Transcription Adipose Tissue Development	Cell Adhesion
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Macular thickness ( 30535121)
Interacting Genes		12 interacting genes: DCAF7 GSC2 HDAC5 ID2 MAP2K3 MAPK1 MAPK14 MBP PAK1 PCBD1 RANBP9 TROAP	18 interacting genes: ACTMAP BANP BYSL DYNLT1 DYRK1A DYRK1B GIGYF1 KRT31 KRT40 KRT8 NBPF19 NOTCH2NLA OIP5 SSC4D TP53BP2 TRAF2 TRIM23 TRO
Entrez ID		9149	10024
HPRD ID		05188	04849
Ensembl ID		ENSG00000105204	ENSG00000135451
Uniprot IDs		A0A9H4CVU7 Q9Y463	F8W130 Q12815
PDB IDs		8C2Z
Enriched GO Terms of Interacting Partners?		MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Muscle Cell Differentiation Cellular Senescence NLRP1 Inflammasome Complex Assembly Negative Regulation Of Muscle Cell Differentiation Regulation Of Striated Muscle Cell Differentiation Cellular Response To UV-B MAP Kinase Activity MAP Kinase Kinase Activity Response To Lipopolysaccharide Mammary Gland Epithelial Cell Proliferation Response To Molecule Of Bacterial Origin Regulation Of Blood Vessel Endothelial Cell Migration Protein Serine Kinase Activity Response To UV-B Stress-activated MAPK Cascade Protein-containing Complex Negative Regulation Of Hippo Signaling P38MAPK Cascade Protein Serine/threonine Kinase Activity Intracellular Signaling Cassette Cellular Response To Vascular Endothelial Growth Factor Stimulus Response To Insulin Nucleoplasm Cellular Response To Lipopolysaccharide Astrocyte Differentiation Canonical Inflammasome Complex Assembly Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Erythrocyte Differentiation Cellular Response To Molecule Of Bacterial Origin Regulation Of Endothelial Cell Migration Cytosol Protein Kinase Activity Lipopolysaccharide-mediated Signaling Pathway Regulation Of Cell Migration Negative Regulation Of Striated Muscle Cell Differentiation Pyroptotic Inflammatory Response Regulation Of Cell Motility Regulation Of Hippo Signaling Regulation Of Myotube Differentiation Positive Regulation Of Cell Migration Regulation Of Locomotion Positive Regulation Of Cell Motility Regulation Of Erythrocyte Differentiation Positive Regulation Of Locomotion Positive Regulation Of Metabolic Process Kinase Activity Positive Regulation Of Metalloendopeptidase Activity Heart Development
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