FAAP24 and RBBP6

Number of citations of the paper that reports this interaction (PubMedID 27107012)
72

Data Source:
BioGRID (two hybrid)

		FAAP24	RBBP6
Description		FA core complex associated protein 24	RB binding protein 6, ubiquitin ligase
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol Fanconi Anaemia Nuclear Complex FANCM-MHF Complex	Nucleus Chromosome Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Nuclear Speck Protein-containing Complex
	Molecular Function	DNA Binding Chromatin Binding Protein Binding	Nucleic Acid Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	DNA Repair DNA Damage Response Interstrand Cross-link Repair	In Utero Embryonic Development DNA Replication Regulation Of DNA Replication MRNA Processing Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Ubiquitination Multicellular Organism Growth Embryonic Organ Development Somite Development
Pathways		Fanconi Anemia Pathway PKR-mediated signaling	RHOBTB1 GTPase cycle Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Adult body size ( 32376654) Body mass index ( 28892062) Body size at age 10 ( 32376654) Brain structure ( 20171287) Chronotype ( 30696823) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Obesity-related traits ( 23251661) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)
Interacting Genes		5 interacting genes: APP EME2 FANCM RBBP6 TERT	44 interacting genes: ACOT13 AGO2 ANAPC16 APOH ASGR1 CAPZA2 CASK CD81 CLK1 CPSF3 EIF4ENIF1 ETS1 EVA1C FAAP24 FBXO7 GLUL GRB2 HP KHDRBS3 LINC00305 LRCH4 MAD2L2 MDM2 MIR19A MIR19B1 NDUFB9 NEK6 PIAS1 PLG RB1 RBP4 RCC1L RPS14 SMN1 SPP1 TFIP11 TP53 TPT1 UBE2I UPF3B VAV2 YBX1 ZBTB38 ZFYVE9
Entrez ID		91442	5930
HPRD ID		14547	02964
Ensembl ID		ENSG00000131944	ENSG00000122257
Uniprot IDs		A0A0S2Z5V6 K7EKQ4 Q9BTP7	Q7Z6E9
PDB IDs		2LYH 2M9M 2M9N 4BXO 4M6W	2C7H 2YSA 2YUR 3ZTG 6E5X
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process Resolution Of Meiotic Recombination Intermediates DNA Recombination Replication Fork Processing Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of MiRNA Transcription Response To Stress Regulation Of MiRNA Metabolic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Mitotic Cell Cycle TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Positive Regulation Of Transdifferentiation RNA-directed RNA Polymerase Complex SiRNA Transcription Meiosis I Cell Cycle Process Protein-folding Chaperone Binding Cellular Response To Stress Telomere Maintenance Acetylcholine Receptor Activator Activity Positive Regulation Of Mitotic Cell Cycle Lipoprotein Particle Positive Regulation Of Protein Import Positive Regulation Of Hair Cycle Telomerase Catalytic Core Complex Telomere Organization Nuclease Activity PTB Domain Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Protein Localization To Nucleus Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization DNA Damage Response Nucleic Acid Metabolic Process RNA-directed RNA Polymerase Activity RNA-templated Transcription RNA-directed DNA Polymerase Activity Response To Norepinephrine DNA Binding Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus	Negative Regulation Of Developmental Process PML Body Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Developmental Process Regulation Of Cell Differentiation Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Differentiation SUMO Transferase Activity Regulation Of Cell Cycle Phase Transition Cellular Response To Actinomycin D Regulation Of MRNA Metabolic Process Protein Domain Specific Binding Negative Regulation Of Multicellular Organismal Process Positive Regulation Of RNA Metabolic Process Nucleoplasm Response To Actinomycin D Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cardiac Epithelial To Mesenchymal Transition Disordered Domain Specific Binding Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Muscle Cell Differentiation Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To UV-C Glial Cell Apoptotic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Locomotion Positive Regulation Of Catabolic Process Negative Regulation Of Matrix Metallopeptidase Secretion Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Antibiotic Regulation Of Cell Cycle G1/S Phase Transition Ubiquitin Protein Ligase Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Protein Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of MRNA Stability Regulation Of Endothelial Cell Migration Regulation Of Metabolic Process Regulation Of Immune System Process Regulation Of Cell Migration Positive Regulation Of B Cell Receptor Signaling Pathway Regulation Of Multicellular Organismal Development Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of RNA Stability Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of MRNA Catabolic Process MiRNA-mediated Post-transcriptional Gene Silencing
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