C19orf40 and EME2

Number of citations of the paper that reports this interaction (PMID 17289582)
99

Data Source:
BioGRID (pull down)

		C19orf40	EME2
Gene Name		chromosome 19 open reading frame 40	essential meiotic structure-specific endonuclease subunit 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Intracellular Membrane-bounded Organelle Fanconi Anaemia Nuclear Complex	Nucleus
	Molecular Function	DNA Binding Chromatin Binding Protein Binding	DNA Binding Endonuclease Activity
	Biological Process	DNA Repair	DNA Repair DNA Recombination Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Fanconi Anemia pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: APP EME2 FANCM TERT	3 interactors: C19orf40 FANCM MUS81
Entrez ID		91442	197342
HPRD ID		14547	16859
Ensembl ID			ENSG00000197774
Uniprot IDs		K7EKQ4 Q9BTP7	A4GXA9
PDB IDs		2LYH 2M9M 2M9N 4BXO 4M6W
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Production Of SiRNA Involved In RNA Interference Negative Regulation Of RNA Interference Transcription, RNA-templated Synaptic Growth At Neuromuscular Junction DNA Metabolic Process Collateral Sprouting In Absence Of Injury Age-dependent Telomere Shortening Telomere Formation Via Telomerase DNA Recombination Telomere Maintenance Via Telomere Shortening Collateral Sprouting Axon Midline Choice Point Recognition DNA Replication Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Nucleic Acid Phosphodiester Bond Hydrolysis Axon Choice Point Recognition Telomere Assembly Nucleobase-containing Compound Metabolic Process Neuron Remodeling Replicative Cell Aging Telomere Maintenance Via Telomerase Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Production Of SiRNA Involved In RNA Interference Cellular Nitrogen Compound Metabolic Process Posttranscriptional Regulation Of Gene Expression Resolution Of Meiotic Recombination Intermediates RNA Interference Replication Fork Processing Replicative Senescence Nitrogen Compound Metabolic Process Cellular Copper Ion Homeostasis RNA Processing RNA-dependent DNA Replication DNA Repair Regulation Of Gene Silencing Chromosome Separation Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To Stimulus RNA Polyadenylation Cellular Response To DsRNA	DNA Repair Cellular Response To DNA Damage Stimulus DNA Metabolic Process Cellular Response To Stress DNA Recombination Response To Intra-S DNA Damage Checkpoint Signaling Nucleic Acid Phosphodiester Bond Hydrolysis Resolution Of Meiotic Recombination Intermediates Replication Fork Processing Chromosome Separation Response To Stress Reciprocal Meiotic Recombination Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Meiotic Chromosome Segregation DNA Catabolic Process, Endonucleolytic Nitrogen Compound Metabolic Process Meiosis I DNA-dependent DNA Replication DNA Catabolic Process Meiotic Nuclear Division Cellular Response To Stimulus Meiotic Cell Cycle Chromosome Segregation
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